17 completed, 5 terminated, 1 not yet recruiting, 1 recruiting. 25 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 25 | Completed 17, Terminated 5, Not yet recruiting 1, Recruiting 1, Unknown 1 |
Follow Candidiasis, Invasive: new trials by email Literature Review of Candidiasis, Invasive trials Research Report on Candidiasis, Invasive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized Study of a Short Duration Therapy for Candidemia Standard of Care (SOC), Shortened duration of antifungal therapy - CANDIDEMIA | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 362 | 2025-07-01 | 2025-03-05 |
| A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis. Fosmanogepix, Caspofungin, Fluconazole - Candidemia, Candidiasis, Invasive | Phase 3 | Recruiting | Basilea Pharmaceutica | 450 | 2024-12-11 | 2026-10-19 |
| A Study of ABCD for Injection in Subjects With Invasive Candidiasis and Invasive Aspergillus Amphotericin B cholesteryl Sulfate Complex for Injection - Invasive Candidiasis, Invasive Aspergillosis | Phase 3 | Completed | CSPC Ouyi Pharmaceutical Co., Ltd. | 31 | 2023-03-30 | 2025-04-09 |
| A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV Echinocandin Followed by Either Oral Ibrexafungerp or Oral Fluconazole SCY-078, Fluconazole, Echinocandin - Candidiasis, Invasive, Candidemia | Phase 3 | Terminated | Scynexis, Inc. | 68 | 2022-08-03 | 2026-08-10 |
| Efficacy of Prophylactic Fluconazole Therapy in Preterm and Very Low Birth Weight Neonates in Preventing Invasive Fungal Infection. Fluconazole, Saline - Invasive Candidiases | Phase 3 | Completed | Services Institute of Medical Sciences, Pakistan | 110 | 2021-05-01 | 2023-05-08 |
| Study of Rezafungin Compared to Standard Antimicrobial Regimen for Prevention of Invasive Fungal Diseases in Adults Undergoing Allogeneic Blood and Marrow Transplantation Rezafungin for Injection, Posaconazole, Fluconazole - Candidemia, Mycoses | Phase 3 | Completed | Mundipharma Research Limited | 602 | 2020-05-11 | 2026-04-13 |
| Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasis Rezafungin for Injection, Caspofungin, Fluconazole - Candidemia, Mycoses | Phase 3 | Completed | Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | 199 | 2018-10-07 | 2023-01-06 |
| Open-Label Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) in Patients With Candidiasis Caused by Candida Auris (CARES) SCY-078 - Candidiasis, Invasive, Candidemia | Phase 3 | Completed | Scynexis, Inc. | 30 | 2017-11-15 | 2024-07-03 |
| Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment Ibrexafungerp - Invasive Candidiasis, Mucocutaneous Candidiasis | Phase 3 | Completed | Scynexis, Inc. | 233 | 2017-04-01 | 2024-11-20 |
| Study to Compare the Efficacy and Safety of Micafungin Versus Conventional Amphotericin B for the Treatment of Neonatal Candidiasis micafungin, amphotericin B deoxycholate - Candidiasis | Phase 3 | Terminated | Astellas Pharma Global Development, Inc. | 30 | 2013-02-01 | 2015-11-04 |
| Empirical Antifungal Treatment in ICUS Micafungin, PLACEBO - Invasive Candidiasis | Phase 3 | Completed | University Hospital, Grenoble | 260 | 2012-07-01 | 2015-03-24 |
| Efficacy of Interferon-gamma in Combination With Anidulafungin for the Treatment of Candidemia Interferon-gamma, Recombinant - Candidemia | Phase 3 | Unknown | Radboud University Medical Center | 20 | 2011-01-01 | 2012-02-14 |
| A Study Of The Efficacy And Safety Of Anidulafungin Vs. Fluconazole In The Treatment Of Patients With Candidemia And/Or Other Forms Of Invasive Candidiasis Anidulafungin/Fluconazole - Candidemia | Phase 3 | Terminated | Pfizer | 17 | 2010-12-01 | 2015-10-28 |
| An Evaluation Of The Effectiveness And Safety Of Anidulafungin Compared To Caspofungin For The Treatment Of Serious Fungal Infection Due To Candida In Patients With A Dysfunctional Immune System Active Anidulafungin, Active Caspofungin - Fungemia, Neutropenia | Phase 3 | Terminated | Pfizer | 21 | 2009-08-01 | 2012-12-20 |
| An Evaluation Of The Effectiveness And Safety Of Anidulafungin Compared To Caspofungin For The Treatment Of Deep Tissue Infection Due To Candida Active anidulafungin, Active Caspofungin - Candidiasis, Fungemia | Phase 3 | Terminated | Pfizer | 41 | 2009-04-01 | 2013-08-01 |
| Study To Assess Pharmacokinetics, Safety & Efficacy of Anidulafungin When Treating Children With Invasive Candidiasis Anidulafungin, Fluconazole - Candidemia | Phase 3 | Completed | Pfizer | 70 | 2009-02-01 | 2019-04-04 |
| Anidulafungin Candidemia/Invasive Candidiasis Intensive Care Study Anidulafungin, Fluconazole, Voriconazole - Invasive Candidiasis | Phase 3 | Completed | Pfizer | 216 | 2008-07-01 | 2011-05-30 |
| Anidulafungin In Treatment Of Candidemia In Asian Subjects Anidulafungin - Candidemia | Phase 3 | Completed | Pfizer | 43 | 2008-01-01 | 2010-03-09 |
| Isavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infections Isavuconazole, Caspofungin, Voriconazole - Candidiasis, Invasive, Candidemia | Phase 3 | Completed | Astellas Pharma Inc | 450 | 2007-03-08 | 2024-12-10 |
| A Multicenter, Randomized, Double-Blind, Comparative Study to Evaluate the Safety, Tolerability, and Efficacy of 2 Dosing Regimens of an Antifungal Drug in the Treatment of Fungal Infections in Adults (0991-801)(COMPLETED) caspofungin acetate - Invasive Candidiasis | Phase 3 | Completed | Merck Sharp & Dohme LLC | 204 | 2006-01-01 | 2017-03-24 |
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Candidemia (20) · Candidiasis (8) · Mycoses (7) · Fungemia (5) · Torulopsis (5) · Invasive Fungal Infections (3) · Pathologic Processes (2) · Sepsis (2) · Systemic Inflammatory Response Syndrome (2) · Aspergillosis (1) · Aspergillosis, Allergic Bronchopulmonary (1) · Blastomycosis (1) · Candidiasis, Chronic Mucocutaneous (1) · Candidiasis, Vulvovaginal (1)
Bacterial Infections and Mycoses (25) · Infections (24) · Invasive Fungal Infections (22) · Pathological Conditions, Signs and Symptoms (21) · Inflammation (19) · Pathologic Processes (19) · Mycoses (18) · Sepsis (18) · Systemic Inflammatory Response Syndrome (18) · Candidiasis (17) · Fungemia (15) · Lung Diseases (2) · Lung Diseases, Fungal (2) · Respiratory Tract Diseases (2)
Fluconazole (10) · Anidulafungin (6) · Caspofungin (6) · Micafungin (6) · Injections (4) · Voriconazole (3) · ibrexafungerp (3) · Amphotericin B (2) · Rezafungin (2) · Echinocandins (1) · Interferon-gamma (1) · Sodium Chloride (1) · Standard of Care (1) · Trimethoprim, Sulfamethoxazole Drug Combination (1) · amphotericin B, deoxycholate drug combination (1)
Pfizer (7) · Astellas Pharma Inc (4) · Scynexis, Inc. (3) · Assistance Publique - Hôpitaux de Paris (1) · Astellas Pharma Global Development, Inc. (1) · Basilea Pharmaceutica (1) · CSPC Ouyi Pharmaceutical Co., Ltd. (1) · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (1) · Merck Sharp & Dohme LLC (1) · Mundipharma Research Limited (1) · National Cancer Institute (NCI) (1) · Radboud University Medical Center (1) · Services Institute of Medical Sciences, Pakistan (1) · University Hospital, Grenoble (1)
United States (14) · Canada (9) · France (9) · Belgium (8) · Germany (8) · Italy (8) · Spain (8) · China (6) · Greece (6) · Brazil (5) · Bulgaria (5) · Israel (5) · Netherlands (5) · Russia (5) · South Africa (5)
David Angulo, MD (2) · Alexandra Hill, MD (1) · Baodong Ye (1) · Corine Delsing, MD (1) · Fang Zhou (1) · Fenge Yang (1) · Jinhai Ren (1) · Jishi Wang (1) · Laura Cox, PhD (1) · Lina Zhang (1) · M Tauseef Omer, MBBS FCPS Pediatrics (1)
PMID 28459966, PMID 28597967, PMID 33891293, PMID 31280481, PMID 21147825, PMID 33438477, PMID 17568028, PMID 19804626, PMID 23676114, PMID 24261608, PMID 24669841, PMID 25902926, PMID 27706483, PMID 29596222, PMID 30289478, PMID 30418357, PMID 32032174, PMID 36442484, PMID 37773627, PMID 38008099, PMID 38502709, PMID 38985561, PMID 39259571, PMID 39468640, PMID 39529079, PMID 41194465, PMID 41940006
2017 (2), 2008 (1), 2009 (1)