20 completed, 9 recruiting, 8 unknown, 7 terminated. 24 Phase 2, 13 Phase 1, 8 Phase 3, 5 Not applicable, 3 Early Phase 1.
Follow sodium thiosulfate: new trials by email Literature Review of sodium thiosulfate trials Research Report on sodium thiosulfate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing the Addition of Pedmark to Cisplatin Chemotherapy for Reducing Drug-Induced Ear Damage in Men With Stage II-III Metastatic Testicular Germ Cell Tumors Audiometric Test, Cisplatin, Computed Tomography - Hearing Loss, Metastatic Malignant Germ Cell Tumor | Phase 1 | Recruiting | City of Hope Medical Center | 44 | 2026-02-19 | 2026-04-17 |
| Quantification of Calcinosis Cutis Disease Burden Using Computed Tomography Images Sodium Thiosulfate (STS), Sodium Thiosulfate Injection - Systemic Sclerosis (SSc), Calcinosis Cutis | Recruiting | Yale University | 56 | 2025-10-14 | 2026-02-17 | |
| Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney Transplantation Sodium Thiosulfate - Renal Transplant, Kidney Transplant | Not applicable | Recruiting | Alp Sener | 120 | 2025-05-03 | 2026-04-13 |
| Intralesional Injection of STS in Treatment of Calcinosis Sodium Thiosulfate (STS) - Systemic Sclerosis (SSc), Dermatomyositis | Phase 2 | Recruiting | Robyn T. Domsic, MD, MPH | 20 | 2025-03-17 | 2026-05-05 |
| Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy Sodium Thiosulfate - Ototoxicity, Drug-Induced | Early Phase 1 | Suspended | Children's Hospital Medical Center, Cincinnati | 33 | 2023-03-01 | 2026-10-22 |
| A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss Audiometric Test, Auditory Brainstem Response, Biospecimen Collection - Childhood Medulloblastoma | Phase 3 | Recruiting | Children's Oncology Group | 225 | 2023-02-20 | 2026-08-25 |
| Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy Sodium Thiosulfate + Mannitol - Ototoxic Hearing Loss | Phase 2 | Recruiting | Sunnybrook Health Sciences Centre | 92 | 2023-02-15 | 2023-04-14 |
| STS Administration on Coronavirus Disease (COVID-19) Patients in Critical Care Sodium Thiosulfate 25% Solution for Injection - COVID-19, Virus Diseases | Phase 2 | Unknown | Hellenic Institute for the Study of Sepsis | 30 | 2022-04-01 | 2023-01-13 |
| Endoscopic Vital Nerve Staining in Gastrointestinal Diseases Sodium thiosulfate and Methylene blue solution - Gastrointestinal Neoplasms, Abnormality of Enteric Nervous System Morphology | Early Phase 1 | Unknown | Affiliated Hospital to Academy of Military Medical Sciences | 100 | 2022-03-01 | 2022-03-15 |
| Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies Sodium Thiosulfate, 5-Fluorouracil, Oxaliplatin - Peritoneal Mesothelioma, Peritoneal Carcinomatosis | Phase 1 | Recruiting | National Cancer Institute (NCI) | 60 | 2021-10-19 | 2026-10-16 |
| Better Evidence and Translation for Calciphylaxis Vitamin K1, Magnesium citrate, Sodium Thiosulfate - Calciphylaxis | Phase 3 | Recruiting | University of Sydney | 350 | 2021-08-26 | 2025-08-13 |
| Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation Seacalphyx (sodium thiosulfate pentahydrate injection BP) 25% - End Stage Renal Disease (ESRD) | Phase 1 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 18 | 2021-03-21 | 2023-12-12 |
| A Multi-institutional Study for Treatment of Children With Newly Diagnosed Hepatoblastoma Using a Modified PHITT Strategy Sodium Thiosulfate Injection, Primary surgery resection, mono CDDP-Group A2 - Hepatoblastoma | Phase 3 | Recruiting | Shanghai Children's Medical Center | 330 | 2021-03-01 | 2026-05-04 |
| Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin Cisplatin, Hearing Handicap Inventory for Adults - Screening, Radiation Therapy - Clinical Stage III Human Papillomavirus (HPV)-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Completed | Hyunseok Kang, MD | 16 | 2020-10-14 | 2024-06-28 |
| Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment DB-020, Placebo - Ototoxicity | Phase 1 | Completed | Decibel Therapeutics | 22 | 2020-02-21 | 2023-07-06 |
| Efficacy of Sodium Thiosulfate in Shoulder Pain in Calcific Tendinitis of the Rotator Cuff Sodium Thiosulfate - Sodium Thiosulfate, Calcific Tendinitis | Phase 2 | Unknown | Soraia Azevedo | 80 | 2020-01-01 | 2021-09-28 |
| Heated Intra-peritoneal Chemotherapy With Doxorubicin and Cisplatin for Abdominal for Pelvic Tumors in Pediatric Patients Cisplatin, Cytoreductive Surgery, Doxorubicin - Malignant Abdominal Neoplasm, Malignant Pelvic Neoplasm | Early Phase 1 | Terminated | Mayo Clinic | 2 | 2019-11-08 | 2025-02-20 |
| Pharmacokinetic Study to Investigate the Bioavailability and Tolerability of 3 Oral Formulations of Sodium Thiosulfate Sodium thiosulfate - Healthy | Phase 1 | Withdrawn | Insel Gruppe AG, University Hospital Bern | 2018-12-01 | 2023-02-09 | |
| Efficacy of Intralesional Sodium Thiosulfate Versus Intralesional Saline for Dystrophic and Idiopathic Calcinosis Cutis Sodium Thiosulfate, Saline Solution - Calcinosis Cutis | Phase 4 | Terminated | University of Central Florida | 5 | 2018-11-02 | 2021-07-01 |
| Sodium Thiosulfate to Preserve Cardiac Function in STEMI Sodium thiosulfate, Sodium chloride 0.9%, primary percutaneous coronary intervention - Myocardial Infarction, Heart Failure | Phase 2 | Unknown | University Medical Center Groningen | 380 | 2018-07-20 | 2021-09-09 |
Showing 20 of 51. Sign in to see all of them.
Calcinosis (6) · Hepatoblastoma (5) · Mesothelioma, Malignant (5) · Calciphylaxis (4) · Central Nervous System Neoplasms (4) · Hearing Loss (4) · Medulloblastoma (4) · Ototoxicity (4) · Calcinosis Cutis (3) · Dermatomyositis (3) · Drug-Related Side Effects and Adverse Reactions (3) · Gastrointestinal Neoplasms (3) · Ovarian Neoplasms (3) · Peritoneal Neoplasms (3) · Adrenocortical Carcinoma (2)
OHSU Knight Cancer Institute (7) · Dana-Farber Cancer Institute (3) · National Cancer Institute (NCI) (3) · Children's Oncology Group (2) · Insel Gruppe AG, University Hospital Bern (2) · University Medical Center Groningen (2) · Affiliated Hospital to Academy of Military Medical Sciences (1) · Alison Ehrlich (1) · Alp Sener (1) · American Regent, Inc. (1) · Brigham and Women's Hospital (1) · Centre Hospitalier St Esprit (1) · Children's Hospital Medical Center, Cincinnati (1) · City of Hope Medical Center (1) · Columbia University (1)
United States (32) · Canada (6) · Australia (3) · China (2) · France (2) · Netherlands (2) · United Kingdom (2) · Greece (1) · New Zealand (1) · Portugal (1) · Switzerland (1) · Thailand (1) · Turkey (Türkiye) (1)
Edward A Neuwelt (4) · David J. Sugarbaker, MD (3) · Edward A. Neuwelt, MD (3) · Jeremy L Davis, M.D. (2) · Adam I Schiffenbauer, M.D. (1) · Alex Chehrazi-Raffle (1) · Alison Ehrlich, MD (1) · Alp Sener (1) · Alp Sener, Dr. (1) · Andrea Morris, MD (1) · Andrew M Blakely, M.D. (1) · Brian D. Badgwell, MD (1) · Craig Sherman, MD (1) · David Cognetti, MD (1)
PMID 27914822, PMID 29924955, PMID 15942915, PMID 21566113, PMID 22227955, PMID 22547603, PMID 23831416, PMID 27884679, PMID 28643069, PMID 30463745, PMID 31160205, PMID 31673978, PMID 34534493, PMID 39186385
R01CA137488 (2), 2015 (1), P30CA033572 (1), P50AR080612 (1), R01AR085316 (1), R01NS044687 (1), U10CA180886 (1)