72 completed, 29 unknown, 21 recruiting, 17 terminated. 168 Phase 3, 16 Phase 2.
Follow Brain Neoplasms: new trials by email Literature Review of Brain Neoplasms trials Research Report on Brain Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| IMPT Versus IMRT for Diffuse Intrinsic Pontine Glioma Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT) - Diffuse Intrinsic Pontine Gliomas (DIPG) | Phase 3 | Not yet recruiting | Shandong Cancer Hospital and Institute | 142 | 2026-12-01 | 2026-10-09 |
| Intraoperative Ultrasound for Brain Tumor Surgery Enhanced by AI BrainUS-AI real-time intraoperative ultrasound segmentation system - Brain Tumor Adult | Phase 3 | Not yet recruiting | Hospital del Rio Hortega | 100 | 2026-12-01 | 2026-09-17 |
| [18F]FET PET for Differentiating Tumor Progression vs Treatment-Related Changes in Brain Metastases Floretyrosine F 18 ([18F]FET) - Brain Metastasis, Radiation Necrosis | Phase 3 | Not yet recruiting | Telix Pharmaceuticals (Innovations) Pty Limited | 381 | 2026-12-01 | 2026-11-12 |
| PRESTO: A Phase III Randomised Controlled Trial of Dose-escalated Proton Beam Therapy Versus Standard of Care Radiotherapy for Functioning Pituitary Tumours Standard dose Intensity-Modulated Radiation Therapy (IMRT), Standard dose Proton Beam Therapy (PBT), Escalated dose Proton Beam Therapy (PBT) - Acromegaly Due to Pituitary Adenoma, Cushing's Disease | Phase 3 | Not yet recruiting | University College, London | 82 | 2026-09-01 | 2026-10-01 |
| Comparison of the Therapeutic Effects of Methylprednisolone and Dexamethasone on Peritumoral Edema During Radiotherapy for Brain Metastases: Methylprednisolone (Corticosteroid), Dexamethasone - Brain Metastases From Solid Tumors | Phase 2 / Phase 3 | Not yet recruiting | The Second Affiliated Hospital of Hainan Medical University | 400 | 2026-04-15 | 2026-04-21 |
| Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases FSRT, HA-WBRT-SIB, Bevacizumab - Lung Adenocarcinoma, Brain Metastases | Phase 3 | Recruiting | Sun Yat-sen University | 220 | 2026-03-20 | 2026-04-06 |
| Evaluation of Neoadjuvant Stereotactic Radiosurgery (SRS) and Multi-fraction SRS Alone for the Treatment of Large Brain Metastases Neoadjuvant Stereotactic Body Radiation Therapy (SBRT), Multi-fraction Stereotactic Body Radiation Therapy (SBRT) - Brain Metastasis | Phase 3 | Not yet recruiting | Maciej Harat | 98 | 2026-01-01 | 2026-01-09 |
| Dexmedetomidine Use for Greater Occipital Nerve Block in Pediatric Posterior Fossa Tumor Surgery. Bupivacaine 0.25%, Dexmedetomidine 1mcg/kg, Blind greater occipital nerve block - Posterior Fossa Tumor | Phase 3 | Recruiting | Children's Cancer Hospital Egypt 57357 | 260 | 2025-12-17 | 2026-10-16 |
| DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers. Entrectinib - Haematological Malignancy, Malignancy | Phase 2 / Phase 3 | Recruiting | Cancer Research UK | 30 | 2025-11-30 | 2025-11-24 |
| Study of TLX101-Tx Plus Standard of Care (SoC) Versus SoC Alone for the Treatment of Patients With Recurrent Glioblastoma TLX-101-Tx + Lomustine, TLX101-Tx - Neoplastic Disease, Glioblastoma | Phase 3 | Recruiting | Telix Pharmaceuticals (Innovations) Pty Limited | 50 | 2025-11-02 | 2026-08-11 |
| Evolution of Hypofractionated Stereotactic Irradiation for Radio-Resistant Brain Metastases From D1-3-5 to D1-2-3 D1-3-5 radiotherapy, D1-2-3 radiotherapy - Brain Metastases | Phase 3 | Not yet recruiting | Centre Paul Strauss | 264 | 2025-10-01 | 2025-09-11 |
| Methylphenidate in Pediatric Brain Tumor Survivors With Cancer-related Fatigue Methylphenidate (MPH), Placebo - Brain Tumor, Pediatric, Cancer-related Fatigue | Phase 3 | Recruiting | Odense University Hospital | 50 | 2025-09-02 | 2026-11-03 |
| Effect of Different Anesthetic Drugs on Electrocorticography (ECOG). Fentanyl (IV), Ketamine (0.5 mg/kg) - Epilepsy, Brain Tumor | Phase 3 | Active not recruiting | Children's Cancer Hospital Egypt 57357 | 88 | 2025-08-18 | 2025-09-10 |
| Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases Bevacizumab, Dexamethasone - Radiation Necrosis, High Grade Glioma (III or IV) | Phase 3 | Recruiting | The Netherlands Cancer Institute | 408 | 2025-06-19 | 2026-07-13 |
| Corticodependent or Corticoresistant Brain Radionecrosis After Radiotherapy for Brain Metastases Bevacizumab, Placebo, Prednisolone - Radionecrosis of Brain, Brain Metastases | Phase 3 | Recruiting | Institut Cancerologie de l'Ouest | 84 | 2025-04-29 | 2025-08-17 |
| Levetiracetam Prophylaxis in Brain Tumor Resection Pilot Levetiracetam, Placebo - Seizures, Brain Tumor | Phase 3 | Not yet recruiting | Hamilton Health Sciences Corporation | 70 | 2025-03-01 | 2024-10-23 |
| Study of Adding or Not Liposomal Transcrocetin (L-TC) With Concomitant HypoFractionated Radiation ThErapy and TEmozolomide in Newly Diagnosed GLioblastoma (GBM) Patients Administration of L-TC, Radiotherapy plus Temozolomide - Glioblastoma | Phase 3 | Not yet recruiting | Institut de cancérologie Strasbourg Europe | 554 | 2025-01-01 | 2024-06-27 |
| Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain Computed Tomography, Fractionated Stereotactic Radiation Therapy, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Active not recruiting | NRG Oncology | 274 | 2024-12-12 | 2026-09-14 |
| A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients Bevacizumab, Microbubble, Low-Intensity Focused Ultrasound - Glioblastoma Multiforme, Glioblastoma | Phase 3 | Recruiting | NaviFUS Corporation | 32 | 2024-11-08 | 2026-04-09 |
| Does Perioperative Intravenous Magnesium Affect Postoperative Quality of Recovery in Craniotomy Surgery Patients? IV magnesium sulfate, Placebo - Brain Tumor, Surgery | Phase 3 | Unknown | Thomas Jefferson University | 110 | 2024-11-01 | 2023-04-12 |
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Glioblastoma (33) · Neoplasm Metastasis (26) · Glioma (24) · Astrocytoma (23) · Carcinoma, Non-Small-Cell Lung (20) · Neoplasms (18) · Central Nervous System Neoplasms (16) · Breast Neoplasms (15) · Gliosarcoma (10) · Lung Neoplasms (9) · Pituitary Neoplasms (9) · Oligodendroglioma (8) · Choroid Plexus Neoplasms (7) · Medulloblastoma (7)
Brain Diseases (168) · Central Nervous System Diseases (168) · Nervous System Diseases (168) · Nervous System Neoplasms (168) · Neoplasms by Site (167) · Central Nervous System Neoplasms (152) · Neoplasms (150) · Neoplasms by Histologic Type (65) · Neoplasms, Glandular and Epithelial (62) · Neoplasms, Germ Cell and Embryonal (61) · Neuroectodermal Tumors (60) · Neoplasms, Nerve Tissue (59) · Neoplasms, Neuroepithelial (54) · Pathological Conditions, Signs and Symptoms (51) · Pathologic Processes (40)
Radiotherapy (25) · Radiosurgery (24) · Temozolomide (21) · Lomustine (11) · Bevacizumab (9) · Carboplatin (8) · Vincristine (8) · Etoposide (7) · Surgical Procedures, Operative (7) · Cisplatin (6) · Cyclophosphamide (6) · Procarbazine (6) · Filgrastim (5) · Gefitinib (5) · Magnetic Resonance Spectroscopy (5)
M.D. Anderson Cancer Center (8) · Sun Yat-sen University (7) · Children's Oncology Group (5) · European Organisation for Research and Treatment of Cancer - EORTC (5) · NRG Oncology (5) · Novartis Pharmaceuticals (5) · Alliance for Clinical Trials in Oncology (4) · Assistance Publique - Hôpitaux de Paris (3) · Celtic Pharma Development Services (3) · AHS Cancer Control Alberta (2) · Bayer (2) · Bristol-Myers Squibb (2) · Children's Cancer Hospital Egypt 57357 (2) · Chinese Academy of Medical Sciences (2) · Hamilton Health Sciences Corporation (2)
United States (77) · Canada (47) · Germany (30) · France (29) · United Kingdom (25) · Italy (24) · China (22) · Netherlands (21) · Australia (20) · Belgium (19) · Spain (19) · Switzerland (18) · Austria (17) · Poland (11) · Brazil (10)
Paul D. Brown, MD (4) · William Shapiro, MD (3) · Andrey S. Bryukhovetskiy, MD (2) · Edward G. Shaw, MD (2) · Roger Stupp, MD (2) · Vinai Gondi (2) · Alexander McEwan, MB, MSc, MD, FRCP (1) · Alison L. Hannah, MBBS (1) · Amar Gajjar, MD (1) · Anna Maria Di Giacomo, PhD,MD (1)
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