398 completed, 134 terminated, 103 recruiting, 92 unknown. 858 Phase 2, 195 Phase 1, 16 Phase 3.
Follow Brain Neoplasms: new trials by email Literature Review of Brain Neoplasms trials Research Report on Brain Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease | Phase 1 / Phase 2 | Not yet recruiting | Jubilant Therapeutics Inc. | 113 | 2028-04-01 | 2026-08-07 |
| A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients Aminolevulinic acid hydrochloride - Pediatric Brain Tumor | Phase 2 | Not yet recruiting | Costas Hadjipanayis | 20 | 2027-08-01 | 2026-10-07 |
| H3K27M-specific Immune Effector Cells Targeting DMG/DIPG H3K27M-EIEs - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma | Phase 1 / Phase 2 | Not yet recruiting | Shenzhen Geno-Immune Medical Institute | 30 | 2027-06-30 | 2026-10-30 |
| Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG Opdualag - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 12 | 2027-03-01 | 2026-09-09 |
| Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) Tovorafenib - High Grade Glioma (HGG) of the Brain With BRAF Aberration, High Grade Glioma (III or IV) | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 79 | 2027-02-01 | 2026-10-20 |
| IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade Astrocytomas IDH1-vac, IS-vac, Temozolomide (TMZ) - Astrocytoma, IDH-Mutant, Grade 3, Astrocytoma, IDH-Mutant, Grade 4 | Phase 2 | Not yet recruiting | German Cancer Research Center | 216 | 2027-02-01 | 2026-10-22 |
| Ceritinib Treatment for Recurrent Meningiomas Ceritinib - Recurrent Meningioma, Grade I and Grade II | Phase 2 | Not yet recruiting | Kevin Petrecca | 10 | 2027-01-01 | 2026-10-23 |
| Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures Panitumumab-IRDye800, Pinpoint-IR9000 endoscopic/handheld device, Explorer Air camera - Brain Tumor | Phase 1 / Phase 2 | Recruiting | Stanford University | 12 | 2026-12-01 | 2026-09-29 |
| Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response LSAM-Cisplatin - Diffuse Midline Glioma (DMG), Diffuse Intrinsic Pontine Glioma (DIPG) | Phase 1 / Phase 2 | Not yet recruiting | NanOlogy, LLC | 20 | 2026-12-01 | 2026-08-18 |
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma PEP-CMV vaccine, Tetanus booster, Nivolumab - Diffuse Midline Glioma, Diffuse Midline High-grade Glioma | Phase 1 / Phase 2 | Suspended | Washington University School of Medicine | 68 | 2026-11-30 | 2026-10-30 |
| Molecularly Stratified Trial for Newly Diagnosed Infant-Type Hemispheric Glioma Alectinib, Entrectinib, Surgery - Infant-Type Hemispheric Glioma | Phase 2 | Not yet recruiting | St. Jude Children's Research Hospital | 50 | 2026-11-01 | 2026-11-04 |
| Lemborexant on Perioperative Sleep Quality in Patients With Brain Tumor Undergoing Surgery Lemborexant 5 mg, placebo - Brain Neoplasms, Sleep Initiation and Maintenance Disorders | Phase 2 | Not yet recruiting | Beijing Tiantan Hospital | 112 | 2026-11-01 | 2026-10-29 |
| Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). BCB-276 - Diffuse Intrinsic Pontine Glioma, DIPG | Phase 2 | Recruiting | BrainChild Bio, Inc | 75 | 2026-09-04 | 2026-10-28 |
| Tarlatamab for SCLC Brain Metastases Tarlatamab - Small Cell Lung Cancer, Brain Metastases, Adult | Phase 2 | Recruiting | Maastricht University Medical Center | 35 | 2026-08-10 | 2026-11-12 |
| Sac-TMT for Active TNBC Brain Metastases Sacituzumab tirumotecan - Metastatic Triple Negative Breast Cancers | Phase 2 | Not yet recruiting | Yale University | 20 | 2026-08-01 | 2026-07-24 |
| A Study of Navlimetostat (BMS-986504) Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5) Navlimetostat, Daraxonrasib, Temozolomide - Solid Tumors | Phase 2 | Recruiting | Bristol-Myers Squibb | 254 | 2026-07-27 | 2026-11-04 |
| Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma LMP744, Conventional Surgery or Biopsy - Recurrent Glioblastoma, Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype | Phase 1 / Phase 2 | Recruiting | National Institute of Neurological Disorders and Stroke (NINDS) | 40 | 2026-07-15 | 2026-10-16 |
| Trial to Study Anti- HCMV Therapy in Breast Cancer Patients With Progressive Intracranial Metastases and CMV Infection Valganciclovir - Brain Cancer Metastatic, CMV Viremia | Phase 2 | Recruiting | The Methodist Hospital Research Institute | 28 | 2026-07-14 | 2026-08-10 |
| Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma. Pre-radiation temozolomide. - High Grade Gliomas, Glioblastoma | Phase 2 | Recruiting | The Cooper Health System | 70 | 2026-07-13 | 2026-10-09 |
Showing 20 of 858. Sign in to see all of them.
Glioblastoma (291) · Glioma (192) · Gliosarcoma (154) · Central Nervous System Neoplasms (146) · Astrocytoma (141) · Oligodendroglioma (102) · Carcinoma, Non-Small-Cell Lung (91) · Breast Neoplasms (75) · Neoplasm Metastasis (62) · Melanoma (61) · Neoplasms (53) · Lung Neoplasms (50) · Diffuse Intrinsic Pontine Glioma (44) · Ependymoma (41)
Nervous System Neoplasms (854) · Nervous System Diseases (853) · Neoplasms by Site (852) · Brain Diseases (851) · Central Nervous System Diseases (849) · Neoplasms (805) · Central Nervous System Neoplasms (712) · Neoplasms by Histologic Type (504) · Neoplasms, Nerve Tissue (482) · Neuroectodermal Tumors (471) · Neoplasms, Germ Cell and Embryonal (466) · Neoplasms, Glandular and Epithelial (437) · Neoplasms, Neuroepithelial (411) · Glioma (215) · Astrocytoma (178)
Temozolomide (116) · Bevacizumab (78) · Radiotherapy (57) · Carboplatin (41) · Radiosurgery (41) · Irinotecan (26) · pembrolizumab (25) · Cisplatin (23) · Erlotinib Hydrochloride (23) · Cyclophosphamide (22) · Etoposide (21) · Nivolumab (21) · Ipilimumab (19) · Carmustine (16) · Capecitabine (15)
National Cancer Institute (NCI) (67) · M.D. Anderson Cancer Center (36) · Duke University (35) · Memorial Sloan Kettering Cancer Center (16) · Novartis Pharmaceuticals (13) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (12) · Fudan University (11) · Sun Yat-sen University (10) · Case Comprehensive Cancer Center (9) · Children's Oncology Group (9) · New Approaches to Brain Tumor Therapy Consortium (9) · St. Jude Children's Research Hospital (9) · Wake Forest University Health Sciences (9) · Alliance for Clinical Trials in Oncology (8) · European Organisation for Research and Treatment of Cancer - EORTC (6)
United States (573) · China (73) · Canada (72) · France (60) · Spain (46) · Germany (43) · Australia (42) · Italy (41) · United Kingdom (33) · Netherlands (31) · Switzerland (26) · Belgium (25) · South Korea (20) · Taiwan (16) · Austria (14)
Henry S. Friedman, MD (9) · David A. Reardon, MD (7) · David Peereboom, MD (5) · Stanislaw R. Burzynski, MD, PhD (5) · Betty Lawrence (4) · Edward G. Shaw, MD (4) · Evanthia Galanis (4) · Jeffrey Raizer, MD (4) · Kevin A Camphausen, M.D. (4) · Lauren E. Abrey, MD (4) · Patrick Wen, MD (4)
PMID 21865400, PMID 25098701, PMID 25303679, PMID 25789053, PMID 26148750, PMID 28592387, PMID 30670498, PMID 31587882, PMID 31838007, PMID 33067126, PMID 34081125, PMID 39024777, PMID 40086048, PMID 10655437, PMID 11452123, PMID 11772431, PMID 11907388, PMID 11937316, PMID 12177103, PMID 12434281, PMID 12749708, PMID 12750523, PMID 1408229, PMID 14506149, PMID 14586216, PMID 14625709, PMID 14670747, PMID 14769136, PMID 14769138, PMID 14769140, PMID 15073861, PMID 15292713, PMID 15514370, PMID 15758009, PMID 15809479, PMID 16011702, PMID 16012795, PMID 16034522, PMID 16078267, PMID 16133802, PMID 16170172, PMID 16265674, PMID 16314647, PMID 16510333, PMID 16533878, PMID 16549835, PMID 16598416, PMID 16645718, PMID 16648043, PMID 16757720
2023 (9), U01CA062399 (9), 2014 (7), 2015 (7), U01CA137443 (6), U10CA025224 (6), 2009 (5), 2018 (5), U10CA021661 (5), 2017 (4), 2019 (4), P30CA033572 (4), U01CA062475 (4), 2008 (3), 2025 (3)