8 completed, 6 unknown, 2 terminated, 2 withdrawn. 18 Phase 2, 6 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 18 | Completed 8, Unknown 6, Terminated 2, Withdrawn 2 |
| Phase 1 | 6 | Completed 4, Unknown 1, Withdrawn 1 |
| Phase 3 | 2 | Terminated 1, Unknown 1 |
Follow ARDS, Human: new trials by email Literature Review of ARDS, Human trials Research Report on ARDS, Human
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Direct Topical Lung T3 Treatment to Improve Outcome & Sequelae of COVID-19 Acute Respiratory Distress Syndrome Instilled T3, Placebo Therapy - Covid19, SARS-CoV Infection | Phase 2 | Withdrawn | University of Minnesota | 2026-01-15 | 2026-02-10 | |
| Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for ARDS Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles, Saline - ARDS, Human | Phase 1 / Phase 2 | Withdrawn | Direct Biologics, LLC | 2024-12-01 | 2024-07-29 | |
| MRG-001 as an Immunoregulatory and Regenerative Therapy for COVID-19 Patients MRG-001, Placebo - COVID-19, ARDS, Human | Phase 2 | Unknown | MedRegen LLC | 40 | 2021-12-01 | 2022-02-15 |
| Universal Anti-Viral Vaccine for Healthy Elderly Adults AlloStim - Virus Diseases, Pneumonia | Phase 1 / Phase 2 | Completed | Mirror Biologics, Inc. | 40 | 2021-07-12 | 2025-01-14 |
| Management of Cytokine Storms in Severe COVID-19 Patients With Autologous Activated Platelet-rich Plasma Therapy autologous activated platelet-rich plasma, Avigan - Covid19, Sars-CoV-2 Infection | Phase 1 / Phase 2 | Unknown | Hayandra Peduli Foundation | 30 | 2020-12-29 | 2021-01-20 |
| Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury Nebulised heparin - Covid19, ARDS, Human | Phase 1 / Phase 2 | Completed | University College Hospital Galway | 40 | 2020-12-23 | 2024-07-24 |
| London's Exogenous Surfactant Study for COVID19 Bovine Lipid Extract Surfactant - ARDS, Human, COVID-19 | Phase 1 / Phase 2 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 20 | 2020-11-23 | 2021-11-11 |
| Pilot Study of Single Dose Bevacizumab as Treatment for Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Patients Bevacizumab, BAT - ARDS, Human, Coronavirus Infection | Phase 2 | Terminated | Maimónides Biomedical Research Institute of Córdoba | 21 | 2020-09-01 | 2021-09-05 |
| Ruxolitinib for Treatment of Covid-19 Induced Lung Injury ARDS Ruxolitinib administration - ARDS, Human, COVID | Phase 2 | Completed | Philipps University Marburg | 15 | 2020-07-01 | 2021-08-24 |
| Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19 Hyperbaric oxygen - SARS (Severe Acute Respiratory Syndrome), Cytokine Storm | Phase 2 / Phase 3 | Terminated | Karolinska Institutet | 34 | 2020-06-03 | 2023-01-09 |
| Using GM-CSF as a Host Directed Therapeutic Against COVID-19 Sargramostim, Normal Saline 0.9% - COVID, Sars-CoV2 | Phase 2 | Completed | Singapore General Hospital | 2 | 2020-06-02 | 2022-05-10 |
| Curosurf® in Adult Acute Respiratory Distress Syndrome Due to COVID-19 poractant alfa - COVID-19, ARDS, Human | Phase 2 | Unknown | Dr Christophe LENCLUD | 20 | 2020-05-29 | 2021-02-03 |
| Inhaled Iloprost for Suspected COVID-19 Respiratory Failure Inhaled ILOPROST - COVID-19, ARDS, Human | Phase 2 | Completed | Hamad Medical Corporation | 40 | 2020-05-23 | 2022-03-29 |
| Mavrilimumab in Severe COVID-19 Pneumonia and Hyper-inflammation (COMBAT-19) Mavrilimumab, Placebo - Covid-19, Acute Respiratory Failure | Phase 2 | Unknown | Ospedale San Raffaele | 50 | 2020-05-22 | 2020-05-26 |
| Use of UC-MSCs for COVID-19 Patients Umbilical Cord Mesenchymal Stem Cells + Heparin along with best supportive care., Vehicle + Heparin along with best supportive care - Corona Virus Infection, ARDS | Phase 1 / Phase 2 | Completed | Camillo Ricordi | 24 | 2020-04-25 | 2021-12-06 |
| Senicapoc in COVID-19 Patients With Severe Respiratory Insufficiency Senicapoc - ARDS, Human, COVID | Phase 2 | Unknown | University of Aarhus | 46 | 2020-04-24 | 2020-10-20 |
| Treatment of ARDS With Instilled T3 Liothyronine Sodium (T3+0.9% sodium chloride) modified formulation specifically for airway instillation., Non-intervention - ARDS, Human, Lung, Wet | Phase 2 | Completed | University of Minnesota | 19 | 2020-03-30 | 2026-11-03 |
| Steroids in Patients With Early ARDS Methylprednisolone, Normal saline intravenously and vitamin B1 per os - Acute Lung Injury, ARDS, Human | Phase 2 / Phase 3 | Unknown | Catholic University of the Sacred Heart | 400 | 2008-02-01 | 2007-11-22 |
Respiratory Distress Syndrome (18) · COVID-19 (13) · Coronavirus Infections (3) · Acute Lung Injury (2) · Pneumonia (2) · Severe Acute Respiratory Syndrome (2) · Cytokine Release Syndrome (1) · Influenza, Human (1) · Pneumonia, Viral (1) · Pulmonary Edema (1) · Respiratory Insufficiency (1) · Thyroid Diseases (1) · Virus Diseases (1)
Lung Diseases (18) · Respiration Disorders (18) · Respiratory Tract Diseases (18) · Infections (16) · Coronaviridae Infections (15) · Nidovirales Infections (15) · RNA Virus Infections (15) · Respiratory Tract Infections (14) · Virus Diseases (14) · Coronavirus Infections (12) · Pneumonia (12) · Pneumonia, Viral (12) · Lung Injury (2) · Endocrine System Diseases (1) · Inflammation (1)
Bevacizumab (1) · Colony-Stimulating Factors (1) · Granulocyte-Macrophage Colony-Stimulating Factor (1) · Hyperbaric Oxygenation (1) · Methylprednisolone (1) · Saline Solution (1) · Sodium Chloride (1) · Surface-Active Agents (1) · Thiamine (1) · Triiodothyronine (1) · favipiravir (1) · mavrilimumab (1) · poractant alfa (1) · sargramostim (1) · senicapoc (1)
University of Minnesota (2) · Camillo Ricordi (1) · Catholic University of the Sacred Heart (1) · Direct Biologics, LLC (1) · Dr Christophe LENCLUD (1) · Hamad Medical Corporation (1) · Hayandra Peduli Foundation (1) · Karolinska Institutet (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Maimónides Biomedical Research Institute of Córdoba (1) · MedRegen LLC (1) · Mirror Biologics, Inc. (1) · Ospedale San Raffaele (1) · Philipps University Marburg (1) · Singapore General Hospital (1)
United States (5) · Germany (2) · Italy (2) · Canada (1) · Denmark (1) · France (1) · Indonesia (1) · Ireland (1) · Qatar (1) · Singapore (1) · Spain (1) · Sweden (1)
Timothy P Rich, MD (2) · Anders Kjellberg, MD (1) · Andreas Neubauer, Prof Dr. (1) · Asger Granfeldt, MD, PhD (1) · Bill Arana (1) · Bodil S Rasmussen, MD, PhD (1) · Camillo Ricordi, MD (1) · David H Ingbar, MD (1) · David Ingbar, MD (1) · Jenny Low, MBBS (1) · Jim Lewis, MD (1) · John Laffey (1) · Kenny Rodriguez-Wallberg, MD, PhD (1) · Klaus T Kristiansen, MD (1)
PMID 17426195, PMID 33127750, PMID 34226219, PMID 34385593, PMID 34529182, PMID 36104785, PMID 37510965, PMID 37633275, PMID 39393522, PMID 40432075