6 completed, 3 unknown, 2 withdrawn. 11 Phase 1, 6 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 6, Unknown 3, Withdrawn 2 |
| Phase 2 | 6 | Completed 4, Unknown 1, Withdrawn 1 |
Follow ARDS, Human: new trials by email Literature Review of ARDS, Human trials Research Report on ARDS, Human
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AllogeneiC Expanded Human MSC Therapy in Patients Recovering From COVID-19 Acute Respiratory Distress Trial intravenous delivery of allogeneic bone marrow-derived MSCs - ARDS, Human | Phase 1 | Withdrawn | BioCardia, Inc. | 2026-01-04 | 2026-01-07 | |
| Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles Infusion Treatment for ARDS Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles, Saline - ARDS, Human | Phase 1 / Phase 2 | Withdrawn | Direct Biologics, LLC | 2024-12-01 | 2024-07-29 | |
| First-In-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALT-100 ALT-100, Normal Saline - ARDS, Human | Phase 1 | Completed | Aqualung Therapeutics Corp. | 32 | 2022-07-05 | 2023-09-14 |
| Universal Anti-Viral Vaccine for Healthy Elderly Adults AlloStim - Virus Diseases, Pneumonia | Phase 1 / Phase 2 | Completed | Mirror Biologics, Inc. | 40 | 2021-07-12 | 2025-01-14 |
| Management of Cytokine Storms in Severe COVID-19 Patients With Autologous Activated Platelet-rich Plasma Therapy autologous activated platelet-rich plasma, Avigan - Covid19, Sars-CoV-2 Infection | Phase 1 / Phase 2 | Unknown | Hayandra Peduli Foundation | 30 | 2020-12-29 | 2021-01-20 |
| Nebulised Heparin to Reduce COVID-19 Induced Acute Lung Injury Nebulised heparin - Covid19, ARDS, Human | Phase 1 / Phase 2 | Completed | University College Hospital Galway | 40 | 2020-12-23 | 2024-07-24 |
| London's Exogenous Surfactant Study for COVID19 Bovine Lipid Extract Surfactant - ARDS, Human, COVID-19 | Phase 1 / Phase 2 | Completed | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 20 | 2020-11-23 | 2021-11-11 |
| Regenerative Medicine for COVID-19 and Flu-Elicited ARDS Using Lomecel-B (RECOVER) Longeveron Mesenchymal Stem Cells (LMSCs), Placebo - ARDS, Human, Covid19 | Phase 1 | Unknown | Longeveron Inc. | 70 | 2020-07-24 | 2024-02-20 |
| MSC-based Therapy in COVID-19-associated Acute Respiratory Distress Syndrome Mesenchymal stromal cell-based therapy - Covid19, ARDS, Human | Phase 1 | Unknown | D'Or Institute for Research and Education | 20 | 2020-07-01 | 2020-08-26 |
| Mesenchymal Stromal Cell Therapy For The Treatment Of Acute Respiratory Distress Syndrome Mesenchymal Stromal Stem Cells - KI-MSC-PL-205 - ARDS, Human, COVID | Phase 1 | Completed | Uppsala University | 7 | 2020-06-17 | 2026-04-30 |
| Use of UC-MSCs for COVID-19 Patients Umbilical Cord Mesenchymal Stem Cells + Heparin along with best supportive care., Vehicle + Heparin along with best supportive care - Corona Virus Infection, ARDS | Phase 1 / Phase 2 | Completed | Camillo Ricordi | 24 | 2020-04-25 | 2021-12-06 |
Respiratory Distress Syndrome (11) · COVID-19 (7) · Acute Lung Injury (1) · Coronavirus Infections (1) · Influenza, Human (1) · Pneumonia (1) · Virus Diseases (1)
Lung Diseases (11) · Respiration Disorders (11) · Respiratory Tract Diseases (11) · Coronaviridae Infections (7) · Infections (7) · Nidovirales Infections (7) · Pneumonia, Viral (7) · RNA Virus Infections (7) · Respiratory Tract Infections (7) · Coronavirus Infections (6) · Pneumonia (6) · Virus Diseases (6) · Lung Injury (1) · Orthomyxoviridae Infections (1)
Saline Solution (1) · Sodium Chloride (1) · Surface-Active Agents (1) · favipiravir (1)
Aqualung Therapeutics Corp. (1) · BioCardia, Inc. (1) · Camillo Ricordi (1) · D'Or Institute for Research and Education (1) · Direct Biologics, LLC (1) · Hayandra Peduli Foundation (1) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (1) · Longeveron Inc. (1) · Mirror Biologics, Inc. (1) · University College Hospital Galway (1) · Uppsala University (1)
United States (3) · Australia (1) · Brazil (1) · Canada (1) · Indonesia (1) · Ireland (1) · Sweden (1)
Bill Arana (1) · Camillo Ricordi, MD (1) · Jim Lewis, MD (1) · Joe GN Garcia, MD (1) · John Laffey (1) · Louis Martin Christoffel, MD (1) · Michael Har-Noy, MD (1) · Oscar Simonsson, MD, PhD (1) · Thomas M Polasek, MBBS (1)