42 completed, 8 recruiting, 6 not yet recruiting, 5 unknown. 36 Not applicable, 9 Phase 3, 7 Phase 4, 6 Phase 2, 2 Phase 1.
Follow Ankle Sprain: new trials by email Literature Review of Ankle Sprain trials Research Report on Ankle Sprain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Functional Recovery After a Recent Lateral Ankle Sprain With Early Initiation of Rehabilitation: Changes in the Ankle-GO Score and Its Association With Return to Sport and Recurrent Sprains. Ankle-GO test and questionnaires - Ankle Sprain | Not applicable | Not yet recruiting | Groupe Hospitalier de la Rochelle Ré Aunis | 76 | 2026-11-01 | 2026-11-04 |
| Collagen Scaffold Bioaugmentation for ATFL Repair in Chronic Ankle Instability Arthroscopic Anterior Talofibular Ligament Repair, Internal Brace Augmentation, REGENETEN Bioinductive Collagen Scaffold - Chronic Ankle Instability, Ankle Sprain | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 84 | 2026-09-01 | 2026-10-16 |
| The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Amateur Athletes With Chronic Ankle Instability Postural Stabilization Training, Vestibulo-Ocular Reflex Exercise in addition to Postural Stabilization Training - Ankle Sprain, Ankle Sprain Strain | Not applicable | Recruiting | Bahçeşehir University | 32 | 2026-07-25 | 2026-10-28 |
| Dynamic Neuromuscular Stability Exercises With and Without Rhythmic Auditory Stimulation in Lateral Ankle Sprain Dynamic Neuromuscular Stabilization with Rhythmic Auditory Stimulation, Dynamic Neuromuscular Stabilization Alone - Ankle Sprain, Lateral Ankle Sprain | Not applicable | Recruiting | Riphah International University | 44 | 2026-07-14 | 2026-08-12 |
| Ankle vs. Hip vs. Combined Strengthening in Chronic Ankle Instability Isometric Ankle Strengthening Program, Hip Strengthening, Combined Isometric Ankle and Hip Strengthening Program - Chronic Ankle Instability, CAI, Ankle Sprain | Not applicable | Recruiting | University of Liege | 45 | 2026-03-02 | 2026-05-26 |
| Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy Total intravenous anesthesia combined with peripheral nerve block (TIVA + PNB) group, General anesthesia combined with peripheral nerve block (GA + PNB) group, Spinal anesthesia - Ankle Sprain, Ankle (Ligaments); Instability (Old Injury) | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 200 | 2026-03-01 | 2026-03-10 |
| the Efficacy of Hyperbaric Oxygen on Acute Ankle Sprain hyperbaric oxygen therapy, non Hyperbaric Oxygen Therapy - Ankle Sprain | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 208 | 2026-03-01 | 2026-02-12 |
| Foot Intensive Rehabilitation With Perturbation Based Training in Ankle Sprain Patients Foot-Intensive Rehabilitation, Foot-Intensive Rehabilitation + Perturbation-Based Training - Ankle Sprain | Not applicable | Completed | University of Lahore | 36 | 2025-12-27 | 2026-06-30 |
| Counterpain PXM Versus Diclofenac Versus Piroxicam Piroxicam plus Counterirritant (brand name Counterpain® PXM)., Diclofenac Sodium 10 mg (Brand Name Hotin® DCL), Piroxicam 0.5% (Brand name Pirofel® gel) - Ankle Sprain, Back Pain | Phase 3 | Completed | Taisho Pharmaceutical Indonesia | 180 | 2025-11-04 | 2026-03-16 |
| Validation of a Portable Ankle Arthrometer Cobra Ankle Arthrometer - Chronic Ankle Instability, CAI, Ankle Sprain | Not yet recruiting | University of Virginia | 62 | 2025-10-01 | 2025-09-09 | |
| Validity and Reliability of Calf Raise Tests in Patients With Achilles Tendon Rupture and Lateral Ankle Sprain Calf Raise Test - Achilles Tendon, Ankle Sprain | Not applicable | Not yet recruiting | Schulthess Klinik | 70 | 2025-10-01 | 2025-09-29 |
| NMES With PNF for Ankle Sprain Rehabilitation Proprioceptive neuromuscular facilitation (PNF) with neuromuscular electrical stimulation (NMES), Proprioceptive neuromuscular facilitation (PNF) only - Ankle Sprain | Not applicable | Recruiting | Fooyin University | 60 | 2025-10-01 | 2025-11-17 |
| A Study on Reducing Opioid Use After Ankle Arthroscopy Opioid Analgesic Regimen, Non-opioid analgesic regimen - Ankle (Ligaments); Instability (Old Injury), Ankle Sprain | Not applicable | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 112 | 2025-09-01 | 2026-06-17 |
| Surgical Management of Lateral Ankle Instability: Modified Broström-Gould Versus Arthroscopic Allograft Reconstruction of the Anterior Talofibular and Calcaneofibular Ligaments. Arthroscopic reconstruction surgery, Open surgery - Ankle Sprain | Not applicable | Recruiting | Universidad Francisco de Vitoria | 36 | 2025-09-01 | 2025-10-01 |
| Semiconductor Embedded Socks for Ankle Sprains Semiconductor Embedded Sock, Control Compression Sock - Ankle Sprain | Not applicable | Recruiting | University of Colorado, Denver | 100 | 2025-04-10 | 2026-05-01 |
| Systematic Ultrasound in the Initial Assessment of Ankle Sprain Ankle Sprain | Completed | Hopital Nord Franche-Comte | 13 | 2025-03-07 | 2026-02-25 | |
| Efficacy of Tecar Device With Exercises in Ankle Sprain TECAR therapy, therapeutic exercises - Ankle Sprain, TECAR Therapy | Not applicable | Completed | Cairo University | 42 | 2024-12-15 | 2026-04-15 |
| Impact of Chronic Ankle Instability on Jumping and Agility in Athletes Functional Performance Testing Battery - Chronic Ankle Instability, Ankle Sprain | Completed | Ankara Yildirim Beyazıt University | 32 | 2024-03-10 | 2025-09-12 | |
| Topical Treatments for Ankle Sprains Etofenamat, Diclofenac - Ankle Sprain | Unknown | Ankara City Hospital Bilkent | 100 | 2024-01-01 | 2024-10-02 | |
| Auto-regulated Blood Flow Restriction in Athletes With Recurrent Ankle Sprain Auto-regulated Blood Flow Restriction Training, Non-regulated Blood Flow Restriction Training, Control group - Ankle Sprain, Ankle Instability | Not applicable | Completed | Prince Sattam Bin Abdulaziz University | 45 | 2023-11-01 | 2025-05-14 |
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Ankle Injuries (64) · Sprains and Strains (5) · Pain (4) · Emergencies (3) · Acute Pain (2) · Agnosia (2) · Back Pain (2) · Joint Instability (2) · Motor Activity (2) · Wounds and Injuries (2) · Ankle Fractures (1) · Arthritis (1) · Athletic Injuries (1) · Blister (1) · Disease (1)
Leg Injuries (63) · Wounds and Injuries (62) · Pathological Conditions, Signs and Symptoms (14) · Neurologic Manifestations (9) · Signs and Symptoms (9) · Joint Diseases (5) · Musculoskeletal Diseases (5) · Pathologic Processes (5) · Pain (4) · Behavior (3) · Disease Attributes (3) · Fractures, Bone (3) · Nervous System Diseases (2) · Neurobehavioral Manifestations (2) · Perceptual Disorders (2)
Diclofenac (6) · Transdermal Patch (2) · diclofenac hydroxyethylpyrrolidine (2) · Anesthesia, Spinal (1) · Celecoxib (1) · Compression Bandages (1) · Control Groups (1) · Conversion to Open Surgery (1) · Electric Stimulation (1) · Electroacupuncture (1) · Exercise (1) · Exercise Therapy (1) · Gels (1) · Hematopoietic Stem Cell Mobilization (1) · Hyperbaric Oxygenation (1)
Second Affiliated Hospital, Zhejiang University, School of Medicine (4) · Hisamitsu Pharmaceutical Co., Inc. (3) · Novartis (3) · University of Virginia (3) · Akdeniz University (2) · Cerimon Pharmaceuticals (2) · Creighton University (2) · Universidad Rey Juan Carlos (2) · Actavis Inc. (1) · Affiliated Dongyang Hospital of Wenzhou Medical University (1) · Ankara City Hospital Bilkent (1) · Ankara Yildirim Beyazıt University (1) · Assistance Publique - Hôpitaux de Paris (1) · Bahçeşehir University (1) · Biologische Heilmittel Heel GmbH (1)
United States (19) · China (5) · Turkey (Türkiye) (5) · Brazil (4) · France (4) · Germany (3) · Spain (3) · Canada (2) · Egypt (2) · Mexico (2) · Pakistan (2) · Belgium (1) · Colombia (1) · Costa Rica (1) · Ecuador (1)
Mustafa Serinken, MD (2) · Axel Baltzer (1) · Beth E Fisher, PhD, PT (1) · Bing Xiong (1) · Bruno de Moraes Prianti (1) · Christiane Macedo, doctor (1) · Corentin Boulay Le Soleuz, Resident physician (1) · Dan Levitt, MD (1) · Diana Marina Camargo Lemos, M.Sc. Epid. (1) · Henry Lau, PhD (1)
PMID 16309613, PMID 25043629, PMID 16000658, PMID 16558526, PMID 16971255, PMID 17190537, PMID 17233912, PMID 18345343, PMID 19460169, PMID 19939283, PMID 19955163, PMID 20338253, PMID 20457737, PMID 20547668, PMID 20730362, PMID 21303520, PMID 21395362, PMID 22459604, PMID 22610971, PMID 22962897, PMID 2345777, PMID 23628755, PMID 23813485, PMID 23855363, PMID 24105612, PMID 24377963, PMID 25617451, PMID 25727519, PMID 26360974, PMID 27259750, PMID 27266885, PMID 27496909, PMID 27594929, PMID 27632874, PMID 27662790, PMID 27684529, PMID 27852621, PMID 28057351, PMID 28265448, PMID 28543566, PMID 28852426, PMID 28946541, PMID 29238450, PMID 29264250, PMID 29514819, PMID 29886432, PMID 30202446, PMID 30612980, PMID 30777845, PMID 30787085
2016 (1), 2025 (1)