175 completed, 38 unknown, 15 withdrawn, 14 recruiting. 152 Not applicable, 45 Phase 2, 19 Phase 1, 18 Phase 3, 15 Phase 4.
Follow Alcohol Abuse: new trials by email Literature Review of Alcohol Abuse trials Research Report on Alcohol Abuse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Project SPACE: Testing Daily Text Messages to Reduce Alcohol Use and HIV Risk Behavior CLT- Concrete text messages, CLT- Abstract text messages, Control messages - HIV, Risk Behavior | Not applicable | Not yet recruiting | Emory University | 240 | 2027-02-01 | 2026-08-19 |
| The Effect of Comorbid Alcohol/Substance Use case (comorbid diagnosis), control - Alcohol Abuse, Alcohol Use Disorder | Recruiting | Abant Izzet Baysal University | 297 | 2026-06-20 | 2026-07-13 | |
| tAN for Substance Use Disorder Sparrow Ascent, Sparrow Ascent (Sham) - Alcohol Use Disorder, Alcohol Abuse | Not applicable | Recruiting | Spark Biomedical, Inc. | 20 | 2026-01-28 | 2026-09-28 |
| Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment and Reduction of Heavy Drinking in Individuals With of Alcohol Use Disorder (AUD) Deep TMS (DTMS), Sham (No Treatment) - Alcohol Use Disorder, Alcoholism | Not applicable | Recruiting | Brainsway | 186 | 2025-11-07 | 2026-10-27 |
| A Study of the Safety and Exploratory Efficacy of Oral AFA-281 in Patients with Alcohol Use Disorder AFA-281 - Alcohol Abuse, Alcohol Abuse/addiction | Phase 2 | Not yet recruiting | Afasci Inc | 36 | 2025-10-01 | 2024-11-29 |
| Team-based Learning Intervention to Prevent Risk Factors for Chronic Diseases - a Cluster Randomized Trial Team-based learning - Cardiovascular Diseases, Obesity Prevention | Not applicable | Not yet recruiting | Professor Fernando Figueira Integral Medicine Institute | 240 | 2025-09-01 | 2025-03-30 |
| Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder Active Transcranial Magnetic Simulation, Sham - Alcohol Use Disorder, Alcohol Abuse | Not applicable | Recruiting | VA Palo Alto Health Care System | 40 | 2025-08-25 | 2025-08-13 |
| Adaptation and Evaluation of Bright Horizons Bright Horizons, Case Management - Alcohol Abuse, Substance Use | Not applicable | Recruiting | Johns Hopkins Bloomberg School of Public Health | 100 | 2025-07-17 | 2026-06-09 |
| Reducing Hazardous Alcohol Use and Optimizing Treatment as Prevention Among Men Living With HIV in Risk Environments Kisoboka, Behavioral Economics, Motivational Interviewing - HIV Antiretroviral Therapy (ART) Adherence, Alcohol Abuse | Not applicable | Recruiting | San Diego State University | 716 | 2025-06-16 | 2026-05-12 |
| Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial Psilocybin, Ketamine - Alcohol Use Disorder, Alcohol Dependence | Phase 2 | Recruiting | University of Iowa | 80 | 2025-06-12 | 2025-11-28 |
| Drivers of Suicide Mobile App Study WisePath for Adults, Active-Control app + electronic wellness resources brochure - Suicide, Suicide, Attempted | Not applicable | Completed | Evidence-Based Practice Institute, Seattle, WA | 127 | 2025-03-05 | 2026-04-17 |
| An Economic and Relationship-strengthening Intervention to Reduce Alcohol Use in Malawi Mlambe - HIV/AIDS, Alcohol Abuse | Not applicable | Recruiting | University of California, San Francisco | 500 | 2025-02-14 | 2026-05-14 |
| Evaluation of Effectiveness of the LifeSkills Training - Lombardia - Primary Shool Program ( Val3P-LST ) life skills primary prevention - Well Being, Drug Addiction | Not applicable | Active not recruiting | Agenzia di Tutela della Salute della Città Metropolitana di Milano | 3927 | 2024-12-01 | 2026-10-05 |
| Improving Help-seeking Propensity Through a Micro-intervention Targeting Common Concerns Among Individuals With Alcohol Problems: A Randomized Controlled Experiment Information intervention - Alcohol Abuse, Harmful Alcohol Use | Not applicable | Active not recruiting | Karolinska Institutet | 200 | 2024-11-18 | 2026-09-15 |
| Motivational Interviewing Intervention For Risky Drinking Treatment Among Indigenous Population Motivational interviewing - Alcohol Abuse | Phase 1 / Phase 2 | Unknown | Department of Public Health Medicine, MARA University of Technology | 36 | 2024-10-01 | 2024-09-04 |
| Virtual Incentive Treatment for Alcohol Contingency Management, Computer Based Training for Cognitive Behavioral Therapy for AUD (CBT4CBT) - Alcohol Use Disorder, Alcohol Drinking | Not applicable | Recruiting | Washington State University | 200 | 2024-06-18 | 2025-05-30 |
| A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners CRAFT Web-Based Intervention, Phone-Based CRAFT, CRAFT Workbook - Alcohol Abuse, Alcohol Use Disorder | Not applicable | Recruiting | Stanford University | 744 | 2024-06-14 | 2026-10-19 |
| Effectiveness and Safety of Probiotics in Protecting Liver Function Probiotic group, Placebo group - Alcohol Abuse | Not applicable | Completed | Wecare Probiotics Co., Ltd. | 70 | 2024-06-03 | 2026-07-30 |
| Tracking Mood: The Effects of Daily Mood Tracking VAS on Alcohol Consumption in Adult Heavy Drinkers Intervention - Alcohol Abuse, Alcohol Drinking | Not applicable | Unknown | Ilona Myllyniemi | 2000 | 2024-05-01 | 2024-05-17 |
| Integration of Neurofunctional Phenotyping Into Investigation of CBT4CBT for AUD Stand-alone web-based cognitive behavioral therapy (CBT4CBT) for alcohol use disorder - Alcohol Abuse, Alcohol Use Disorder | Not applicable | Completed | Virginia Commonwealth University | 248 | 2024-04-10 | 2025-06-08 |
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Alcoholism (262) · Substance-Related Disorders (66) · Alcohol Drinking (35) · Alcohol-Related Disorders (17) · Depression (17) · Anxiety Disorders (14) · Stress Disorders, Post-Traumatic (14) · Tobacco Use Disorder (10) · Marijuana Abuse (9) · Acquired Immunodeficiency Syndrome (8) · Mental Disorders (8) · Schizophrenia (8) · Behavior, Addictive (7) · Tobacco Use (6) · Binge Drinking (4)
Chemically-Induced Disorders (262) · Mental Disorders (254) · Alcohol-Related Disorders (245) · Substance-Related Disorders (196) · Behavior (83) · Drinking Behavior (38) · Behavioral Symptoms (23) · Pathological Conditions, Signs and Symptoms (16) · Infections (15) · RNA Virus Infections (15) · Stress Disorders, Traumatic (15) · Trauma and Stressor Related Disorders (15) · Virus Diseases (15) · Blood-Borne Infections (14) · Communicable Diseases (14)
Ethanol (28) · Motivational Interviewing (15) · Crisis Intervention (13) · Sugars (9) · Cognitive Behavioral Therapy (7) · Methods (6) · Mass Screening (5) · Naltrexone (5) · Therapeutics (5) · Counseling (4) · Dutasteride (4) · Quetiapine Fumarate (4) · Secondary Prevention (4) · Topiramate (4) · Control Groups (3)
Boston Children's Hospital (10) · Brown University (10) · UConn Health (9) · Karolinska Institutet (7) · University of California, San Francisco (7) · University of Washington (6) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (5) · Northwell Health (5) · Yale University (5) · Dartmouth-Hitchcock Medical Center (4) · King's College London (4) · Massachusetts General Hospital (4) · University of North Carolina, Chapel Hill (4) · Medical University of South Carolina (3) · RAND (3)
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John R Knight, MD (4) · Anne H Berman, PhD (3) · John R. Knight, MD (3) · Michael McDonell, PhD (3) · Alan I Green, MD (2) · Amy Conroy, PhD (2) · Anthony Spirito, PhD (2) · Frederic C Blow, PhD (2) · Jennis Freyer-Adam, Dr (2) · Jon Morgenstern, Ph.D. (2) · Jonathan Covault, MD, PhD (2) · Karen C Osilla, PhD (2) · Kate B Carey, PhD (2) · Michael J Zvolensky, Ph.D. (2) · Peter Monti, PhD (2)
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P60AA003510 (4), P60AA013759 (2), R01AA009892 (2), R01AA015606 (2), 2023 (1), F31AA024682 (1), F31AA028694 (1), K01AA024519 (1), K01AA026647 (1), K23AA015616 (1), K23AA020865 (1), K23DA048162 (1), K99AA025401 (1), M01RR006192 (1), P20AA017839 (1)