21 completed, 20 recruiting, 15 unknown, 5 not yet recruiting. 67 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 67 | Completed 21, Recruiting 20, Unknown 15, Not yet recruiting 5, Active not recruiting 4, Enrolling by invitation 1, Withdrawn 1 |
Follow Adrenocortical Hyperfunction: new trials by email Literature Review of Adrenocortical Hyperfunction trials Research Report on Adrenocortical Hyperfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| [11C]Metomidate PET-CT vs Usual Care for People With Primary Aldosteronism: a Proof-of-concept Study [11C] Metomidate PETCT, Adrenal Venous Sampling - Primary Aldosteronism | Not applicable | Recruiting | Chinese University of Hong Kong | 32 | 2026-11-01 | 2026-10-26 |
| Comparing Inclisiran Versus Statin for Primary Aldosteronism inclisiran, Lipophilic statins (such as Simvastatin, Atorvastatin, Fluvastatin, Lovastatin,Pitavastatin), Spironolactone (drug) - Primary Aldosteronism | Not applicable | Recruiting | Third Military Medical University | 50 | 2026-10-01 | 2026-10-21 |
| Regular Sauna Use to Lower Blood Pressure in Primary Aldosteronism sauna session - Primary Aldosteronism, Hypertension | Not applicable | Not yet recruiting | University of Calgary | 10 | 2026-09-30 | 2026-08-31 |
| Baxdrostat and Molecular Imaging of Adrenal Cytoreduction in Primary Aldosteronism baxdrostat - Primary Aldosteronism | Not applicable | Not yet recruiting | Queen Mary University of London | 30 | 2026-09-15 | 2026-09-02 |
| Endoscopic Ultrasound-Guided Ethanol Ablation for Aldosterone-Producing Adenoma Endoscopic Ultrasound-Guided Ethanol Ablation - Primary Aldosteronism, Aldosterone-Producing Adenoma | Not applicable | Not yet recruiting | Chongqing Medical University | 30 | 2026-07-15 | 2026-07-14 |
| Intensive vs. Standard Blood Pressure Control in Primary Aldosteronism Intensive BP control, Standard BP control - Primary Aldosteronism | Not applicable | Recruiting | Chongqing Medical University | 3830 | 2026-07-07 | 2026-09-21 |
| EndoSense: Continuous Real-Time Monitoring of Health Markers in Endocrine and Metabolic Disorders Sequential Dietary Sodium Modulation - Endocrine Disorders, Hypertension | Not applicable | Active not recruiting | Felix Beuschlein | 100 | 2026-07-03 | 2026-07-27 |
| Radiofrequency Ablation Versus Adrenalectomy for Adenoma in Patients With Primary Aldosteronism and Hypertension RFA -radiofrequency ablation, Adrenalectomy - Primary Aldosteronism Due to Conn Adenoma, Radiofrequency Ablation Treatment | Not applicable | Recruiting | University Hospital, Toulouse | 134 | 2026-06-05 | 2026-06-11 |
| Efficacy and Safety of Finerenone Compared to Spironolactone in Treatment of Primary Aldosteronism Finerenone - Primary Aldosteronism, Endocrine Hypertension | Not applicable | Recruiting | Bangladesh Medical University | 104 | 2026-04-15 | 2026-07-07 |
| IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion Intervention 1: Adrenalectomy, Intervention 2: Semaglutide - Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS) | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 75 | 2026-03-05 | 2026-03-27 |
| Trial of Aldosterone-hybrid SteRoid for Guiding curablE Treatment of Primary Aldosteronism (TARGET-PA) Hybrid hormones - Hyperaldosteronism; Primary, Primary Aldosteronism Due to Aldosterone Producing Adenoma | Not applicable | Recruiting | Changi General Hospital | 120 | 2026-01-15 | 2026-10-02 |
| Genetic Predisposition to High Blood Pressure Adrenalectomy - Hypertension, Primary Aldosteronism | Not applicable | Enrolling by invitation | Linkoeping University | 76 | 2026-01-01 | 2026-02-02 |
| Sequential Combined Versus Single-Strategy Adrenal Venous Sampling for Primary Aldosteronism(SCOPE) sequential combined AVS - Primary Aldosteronism | Not applicable | Recruiting | Shumin Yang | 456 | 2025-12-25 | 2025-12-24 |
| REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD) REMS - Osteogenesis Imperfecta, Osteoporosis | Not applicable | Recruiting | Meyer Children's Hospital IRCCS | 100 | 2025-12-04 | 2026-02-17 |
| PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism 68Ga-pentixafor PET/CT - Primary Aldosteronism, Secondary Hypertension | Not applicable | Recruiting | Seoul National University Hospital | 90 | 2025-06-25 | 2025-06-18 |
| Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders Participants will use the biossensor for 48 h - Cushing Syndrome, Primary Aldosteronism | Not applicable | Not yet recruiting | University of Sao Paulo General Hospital | 246 | 2025-06-01 | 2025-05-20 |
| The Comparison of Single Catheter and Double Catheter Adrenal Vein Sampling Methods Based on the Upper Limb Approach Single catheter adrenal vein sampling, Double catheters adrenal vein sampling - Primary Aldosteronism | Not applicable | Not yet recruiting | Army Medical University, China | 70 | 2024-12-30 | 2024-12-17 |
| 68Ga-Pentixafor PET/CT Versus Adrenal Vein Sampling in Diagnosing Unilateral Subtype of Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion (PREDICT) 68Ga-Pentixafor PET/CT, AVS - Primary Aldosteronism, Autonomous Cortisol Secretion | Not applicable | Recruiting | Qifu Li | 178 | 2024-08-01 | 2026-02-05 |
| Primary Aldosteronism: Superselective Embolization vs. Laparoscopic Endocrine Curative Therapy Superselective adrenal artery embolization or adrenalectomy - Primary Aldosteronism, Suprarenalectomy | Not applicable | Recruiting | Xinjiang Medical University | 570 | 2024-08-01 | 2025-04-15 |
| Non Invasive Imaging Methods for Detecting PA：a Clinical PET Study of 18F-Pentixather [18F]AlF-NOTA-Pentixather - Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral) | Not applicable | Unknown | Fangfang Sun | 20 | 2024-06-12 | 2024-09-03 |
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Hyperaldosteronism (53) · Cushing Syndrome (17) · Hypertension (10) · Adrenocortical Adenoma (7) · Adrenal incidentaloma (4) · Obesity (4) · ACTH Syndrome, Ectopic (3) · Adrenal Insufficiency (3) · Adrenal Gland Diseases (2) · Endocrine System Diseases (2) · Hypokalemia (2) · Overweight (2) · Pheochromocytoma (2) · Sleep Apnea Syndromes (2) · Addison Disease (1)
Adrenal Gland Diseases (65) · Endocrine System Diseases (65) · Cardiovascular Diseases (14) · Neoplasms (12) · Vascular Diseases (12) · Pathological Conditions, Signs and Symptoms (10) · Nutritional and Metabolic Diseases (9) · Adrenal Cortex Diseases (7) · Adrenal Cortex Neoplasms (7) · Adrenal Gland Neoplasms (7) · Endocrine Gland Neoplasms (7) · Neoplasms by Site (7) · Metabolic Diseases (6) · Body Weight (5)
Spironolactone (4) · Adrenalectomy (3) · Radiofrequency Ablation (2) · Surgical Procedures, Operative (2) · ALN-PCS (1) · Adiposity (1) · Adrenocorticotropic Hormone (1) · Aftercare (1) · Aldosterone (1) · Amlodipine (1) · Atorvastatin (1) · Blood Specimen Collection (1) · Cinnarizine (1) · Clarithromycin (1) · Detection Algorithms (1)
Chongqing Medical University (4) · Haukeland University Hospital (3) · Queen Mary University of London (3) · Third Military Medical University (3) · Assistance Publique - Hôpitaux de Paris (2) · Chinese Academy of Medical Sciences, Fuwai Hospital (2) · Chinese University of Hong Kong (2) · Qifu Li (2) · Second Affiliated Hospital of Nanchang University (2) · Seoul National University Hospital (2) · University Hospital Padova (2) · University Hospital, Caen (2) · University Hospital, Toulouse (2) · Army Medical University, China (1) · Assistance Publique Hopitaux De Marseille (1)
China (20) · France (12) · United Kingdom (5) · United States (4) · Italy (3) · Norway (3) · South Korea (3) · Sweden (3) · Hong Kong (2) · Bangladesh (1) · Brazil (1) · Canada (1) · Egypt (1) · Finland (1) · Japan (1)
Shumin Yang, MD, PhD (2) · David H Ellison, MD (1) · Dong Yifei, Doctor (1) · Enders KW Ng, MB ChB (1) · Felix Beuschlein, Prof. Dr. med. (1) · Gian Paolo Rossi, MD (1) · Grethe Ueland, MD (1) · Gunnar Mellgren, MD.PhD (1) · Haitham M Badawy, PhD (1) · Hui Dong, MD (1) · Jae Hyeon Kim (1) · Jenifer M Brown, MD (1)
PMID 26934393, PMID 15657580, PMID 17161262, PMID 28576687, PMID 29279316, PMID 29987110, PMID 32327102, PMID 36795418, PMID 16508586, PMID 19349554, PMID 21828936, PMID 32206838, PMID 32890265, PMID 35218017, PMID 37870836, PMID 11074243, PMID 15356010, PMID 17901112, PMID 18398342, PMID 18539224, PMID 19783236, PMID 21270113, PMID 218482, PMID 22331382, PMID 22743644, PMID 22890008, PMID 23231595, PMID 23603377, PMID 23648698, PMID 24218436, PMID 24893135, PMID 25002246, PMID 26156970, PMID 26199389, PMID 26760044, PMID 27011114, PMID 27315757, PMID 27325147, PMID 27512976, PMID 28385310, PMID 28420172, PMID 29129575, PMID 29189215, PMID 29709927, PMID 29801012, PMID 30042959, PMID 30137397, PMID 30403797, PMID 30590677, PMID 30601318
2018 (1), 2025 (1), K23DK142038 (1), R01HL075614 (1), R01HL153004 (1)