10 completed, 8 unknown, 4 recruiting, 2 not yet recruiting. 15 Not applicable, 7 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 15 | Completed 6, Unknown 5, Not yet recruiting 2, Recruiting 2 |
| Phase 2 | 7 | Completed 2, Recruiting 2, Unknown 2, Withdrawn 1 |
| Phase 4 | 1 | Unknown 1 |
Follow Acute Stress Disorder: new trials by email Literature Review of Acute Stress Disorder trials Research Report on Acute Stress Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of the Preventive Effect of Defusing on Traumatic Kindling Defusing, Psychological First Aid (PFA) - Acute Stress Disorder, Post Traumatic Stress Disorder PTSD | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 70 | 2026-11-01 | 2026-09-30 |
| Early Intervention to Prevent Development of PTSD in Burn Survivors and Their Caregivers Promotion of Emotional Disclosure for Burns (PoED-B), minimally Enhanced Usual Care control (mEUC) - Posttraumatic Stress Disorder, Burns | Not applicable | Not yet recruiting | University of Southern California | 44 | 2026-08-01 | 2026-06-18 |
| Adolescent Stress and Substance Intervention Subsequent to Trauma ASSIST Video Intervention - PTSD, Substance Use Disorder (SUD) | Not applicable | Recruiting | Rhode Island Hospital | 92 | 2026-03-03 | 2026-07-09 |
| BXCL501 After Stress to Increase Recovery Success BXCL501 (dexmedetomidine HCl), Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 100 | 2026-02-23 | 2026-04-14 |
| Safety & Efficacy of Intranasal Dexmedetomidine, Fentanyl & Midazolam in the Pediatric Emergency Room Intranasal Dexmedetomidine (4 mcg/kg), Intranasal Fentanyl (2 mcg/kg), Intranasal Midazolam (5 mg/kg) - Acute Stress Disorder, Anxiety | Phase 2 | Withdrawn | Nationwide Children's Hospital | 2025-09-01 | 2025-09-10 | |
| Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL) Cyclobenzaprine HCl, Placebo - Acute Stress Reaction, Acute Stress Disorder | Phase 2 | Recruiting | University of North Carolina, Chapel Hill | 180 | 2025-03-25 | 2026-10-22 |
| Internet-delivered Trauma-focused Cognitive-behavioral Therapy as an Early Intervention After Sexual Trauma Condensed Internet delivered prolonged exposure (CIPE) - Acute Stress Disorder, Post Traumatic Stress Disorder | Not applicable | Unknown | Karolinska Institutet | 30 | 2024-10-01 | 2024-07-16 |
| Condensed Digital Prolonged Exposure for Individuals Treated Within Somatic Trauma Care. Condensed Internet delivered prolonged exposure (CIPE) - Post Traumatic Stress Disorder, Acute Stress Disorder | Not applicable | Unknown | Karolinska Institutet | 250 | 2024-09-01 | 2024-07-10 |
| Feasibility Study of the Self-Care Immediate Stabilization Procedure (ISP) ® After a Traumatic Experience Eye Movement Desensitization and Reprocessing (EMDR) - Post-traumatic Stress Disorder, Acute Stress Disorder | Not applicable | Unknown | Tel Aviv University | 200 | 2024-04-01 | 2024-03-27 |
| EMDR Flash Group Protocol for Earthquake Survivors EMDR Flash Group Protocol - Post-traumatic Stress Disorder (PTSD), Acute Stress Disorder | Not applicable | Completed | Istanbul Galata University | 410 | 2023-03-02 | 2026-06-29 |
| Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety Capnometry-Guided Respiratory Intervention, Psycho-Education - Anxiety Disorders, Trauma | Not applicable | Recruiting | University of Texas at Austin | 180 | 2022-08-22 | 2025-08-24 |
| PTSD Prevention Using Oral Hydrocortisone Placebo, Hydrocortisone - PTSD, Acute Stress Disorder | Phase 2 | Completed | Rachel Yehuda | 201 | 2022-01-12 | 2026-03-19 |
| Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health No specific intervention - Inflammatory Bowel Diseases, Depressive Episode | Completed | Momentum Data | 19469 | 2022-01-05 | 2025-06-15 | |
| Comparing Standard vs. Modified Reconsolidation Blockade for the Treatment of Psychological Trauma Propranolol, Placebo - Trauma and Stressor Related Disorders, Post Traumatic Stress Disorder | Phase 2 | Unknown | Douglas Mental Health University Institute | 150 | 2021-08-01 | 2021-07-29 |
| Micro-Dose, Macro-Impact: Leveraging Psychedelics in Frontline Healthcare Workers During the COVID-19 Pandemic Sublingual Micro-Dose Ketamine - Acute Stress Disorder | Phase 4 | Unknown | Limbic Medical | 30 | 2020-04-15 | 2021-02-24 |
| Needs, Perceptions and Acute Stress of Healtcare Workers Caring for COVID-19 Patients in South America Online survey - Acute Stress Disorder | Completed | Universidad Miguel Hernandez de Elche | 1800 | 2020-04-01 | 2022-09-19 | |
| GASA-CIR Trail (Guidance and the Symptoms of Acute Stress and Anxiety in Critically Ill Patients Relatives in Intensive Care Unit) website and brochure - Acute Stress Disorder, Anxiety | Not applicable | Unknown | Federal University of Rio Grande do Sul | 190 | 2019-12-10 | 2020-01-13 |
| Post-traumatic Stress Injuries Among Paramedics and Emergency Dispatchers Psychological first aid, Usual organisational intervention - Stress Disorders, Post-Traumatic, Acute Stress Disorder | Not applicable | Unknown | Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal | 70 | 2019-10-21 | 2019-12-17 |
| The Visiting Child and His Family in ICU interview - Intensive Care, Child | Not applicable | Completed | Centre Hospitalier Universitaire de Besancon | 57 | 2019-09-26 | 2025-01-16 |
| Swiss TrAumatic biRth Trial Brief computerized intervention, Attention placebo control - Posttraumatic Stress Disorder, Acute Stress Disorder | Not applicable | Completed | Centre Hospitalier Universitaire Vaudois | 147 | 2018-08-02 | 2022-08-17 |
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Stress Disorders, Traumatic, Acute (25) · Stress Disorders, Post-Traumatic (19) · Anxiety Disorders (7) · Wounds and Injuries (5) · Adjustment Disorders (3) · Depression (3) · Trauma and Stressor Related Disorders (3) · Depressive Disorder (2) · Substance-Related Disorders (2) · Agoraphobia (1) · Attention Deficit Disorder with Hyperactivity (1) · Bipolar Disorder (1) · Body Dysmorphic Disorders (1) · Burns (1) · COVID-19 (1)
Mental Disorders (24) · Stress Disorders, Traumatic (24) · Trauma and Stressor Related Disorders (22) · Behavior (5) · Behavioral Symptoms (4) · Chemically-Induced Disorders (2) · Mood Disorders (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Attention Deficit and Disruptive Behavior Disorders (1) · Bipolar and Related Disorders (1) · Coronaviridae Infections (1) · Coronavirus Infections (1) · Digestive System Diseases (1) · Gastroenteritis (1)
Dexmedetomidine (2) · Propranolol (2) · Psychological First Aid (2) · Eye Movement Desensitization Reprocessing (1) · Fentanyl (1) · Hydrocortisone (1) · Interviews as Topic (1) · Prazosin (1) · Sugars (1) · cyclobenzaprine (1)
Centre Hospitalier Universitaire Vaudois (2) · Douglas Mental Health University Institute (2) · Hospices Civils de Lyon (2) · Karolinska Institutet (2) · University of North Carolina, Chapel Hill (2) · Centre Hospitalier Universitaire de Besancon (1) · Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal (1) · Federal University of Rio Grande do Sul (1) · Istanbul Galata University (1) · Limbic Medical (1) · Momentum Data (1) · Nationwide Children's Hospital (1) · Rachel Yehuda (1) · Rhode Island Hospital (1) · Stanford University (1)
United States (9) · Canada (3) · France (3) · Switzerland (3) · Israel (2) · Sweden (2) · Argentina (1) · Brazil (1) · Chile (1) · Colombia (1) · Ecuador (1) · Spain (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Samuel McLean, MD (2) · Alain Brunet, Ph.D. (1) · Alain Brunet, PhD. (1) · Andre Atoian, MD (1) · Andrew McGovern, MD (1) · Antje Horsch, D.Clin.Psych. (1) · Antje Horsch, DClinPsych (1) · Christopher Jones, MD (1) · Jonathan Chang, MD (1) · Jose J Mira, PhD (1) · Luc De Montigny (1) · Markus A Landolt, PhD (1) · Oren Asman, LLD (1)
PMID 24062371, PMID 28453969, PMID 31892657, PMID 33175877, PMID 35589975, PMID 37603846, PMID 37759037, PMID 38154074, PMID 38418244, PMID 38767196, PMID 39447384
2016 (1), 2017 (1), 2023 (1), K23MH141296 (1), R21DA062071 (1)