13 completed, 11 unknown, 4 not yet recruiting, 3 terminated. 18 Not applicable, 2 Phase 2, 2 Phase 4, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 18 | Completed 9, Unknown 5, Not yet recruiting 3, Terminated 1 |
| Phase 2 | 2 | Not yet recruiting 1, Terminated 1 |
| Phase 4 | 2 | Completed 1, Unknown 1 |
| Phase 3 | 1 | Not yet recruiting 1 |
Follow Acute on Chronic Liver Failure: new trials by email Literature Review of Acute on Chronic Liver Failure trials Research Report on Acute on Chronic Liver Failure
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Early Initiation of Midodrine for Control and Prevention of Ascites and Its Related Complications in Acute-on-chronic Liver Failure. Midodrine, Standard Medical Treatment - Acute on Chronic Liver Failure | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 113 | 2026-02-05 | 2026-02-20 |
| Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed Terlipressin Injectable Product - Acute on Chronic Liver Failure | Phase 2 / Phase 3 | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 60 | 2025-02-10 | 2025-02-07 |
| Goal Directed Ammonia Lowering Therapy in Hyperammonemic ACLF Patients With no Overt HE to Reduce Major Adverse Liver Related Outcomes (GOAL Trial) Lactulose, Rifaximin, Standard Medical treatment - Acute on Chronic Liver Failure | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 90 | 2025-02-05 | 2025-02-04 |
| Safety and Efficacy of Continuous Infusion of Terlipressin With Norepinephrine Versus Norepinephrine Alone in Improving Outcomes of Acute Kidney Injury in Acute on Chronic Liver Failure With Septic Shock Terlipressin, Norephrine - Acute on Chronic Liver Failure | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 126 | 2024-08-15 | 2024-08-16 |
| Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLF MEX-CD1 Dialysis - Acute on Chronic Liver Failure, Multiple Organ Failure | Not applicable | Completed | Mexbrain | 11 | 2024-06-21 | 2026-04-29 |
| An Open-label Randomized Controlled Trial Comparing the Role of Therapeutic Plasma-exchange in Ameliorating Secondary Organ Dysfunctions in Patients With ACLF and Develop Biomarkers of Treatment Response Plasma Exchange, Standard Medical Treatment - Acute on Chronic Liver Failure | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 190 | 2024-03-01 | 2024-02-26 |
| Lactate Kinetics as a Predictor of Survival in ACLF With Septic Shock No intervention - Acute on Chronic Liver Failure | Unknown | Institute of Liver and Biliary Sciences, India | 100 | 2023-11-05 | 2023-11-03 | |
| To Study the Role of Plasma Von Willebrand Factor Antigen (vWF) to A Disintegrin-like and Metalloproteinase With Thrombospondin Type-1 Motifs 13 (ADAMTS-13) Activity Ratio as a Predictor of Development of Extrahepatic Organ Failure in Acute on Chronic Liver Failure (ACLF) Patients. Acute on Chronic Liver Failure | Unknown | Institute of Liver and Biliary Sciences, India | 50 | 2023-10-07 | 2023-10-04 | |
| Prognostic Significance of Acute Change in Liver and Splenic Stiffness in Patients of Acute on Chronic Liver Failure No intervention - Acute on Chronic Liver Failure | Unknown | Institute of Liver and Biliary Sciences, India | 200 | 2023-09-25 | 2023-10-05 | |
| Characterization of Metabolomic Fingerprints in Patients With Acute Liver Failure and Acute-on-chronic Liver Failure With Hepatic Encephalopathy Blood collection - Hepatic Encephalopathy, Acute Liver Failure | Withdrawn | Assistance Publique - Hôpitaux de Paris | 2023-09-01 | 2024-08-01 | ||
| To Compare Relaxed Rotational Thromboelastometry Cut-offs With Standard Cut-offs for Guiding Blood Product Use Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure Patients Relaxed Rotational Thromboelastometry, Standard Coagulation Tests - Liver Cirrhosis, Acute on Chronic Liver Failure | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 1050 | 2023-02-02 | 2023-06-18 |
| CytOSorb TreatMent Of Critically Ill PatientS Registry CytoSorb - Septic Shock, Acute Respiratory Distress Syndrome | Recruiting | CytoSorbents, Inc | 3000 | 2022-06-22 | 2026-10-20 | |
| CytoSorb® in Patients With Acute on Chronic Liver Failure CytoSorb® treatment - Acute on Chronic Liver Failure, Alcoholic Hepatitis | Withdrawn | CytoSorbents Europe GmbH | 2022-03-15 | 2022-11-29 | ||
| Acute Hemodynamic Response to Carvedilol in Predicting Survival in Acute on Chronic Liver Failure Patients - A Pilot Study. Carvedilol 12.5 MG - Acute on Chronic Liver Failure | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 50 | 2022-01-07 | 2022-01-11 |
| Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy Rotational thromboelastometry - Acute on Chronic Liver Failure, Variceal Hemorrhage | Not applicable | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 262 | 2021-11-15 | 2026-10-06 |
| Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension Albumin + electrolyte solution, POCUS guided fluid resuscitation - Cirrhosis, Liver, Sepsis | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 350 | 2020-02-01 | 2025-09-02 | |
| Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF) HepaStem, Placebo - Acute on Chronic Liver Failure | Phase 2 | Terminated | Cellaion SA | 133 | 2020-01-21 | 2024-05-22 |
| A Study of AARC Standards on Diagnosis and Treatment of Patients With HBV-ACLF in China (AARC China Study) No intervention - Acute on Chronic Liver Failure, HBV | Unknown | Qin Ning | 3000 | 2019-07-02 | 2019-08-13 | |
| Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment Chinese herbal medicine, Control (blank) - Acute on Chronic Liver Failure, Traditional Chinese Medicine | Not applicable | Completed | Beijing 302 Hospital | 516 | 2019-01-10 | 2022-03-31 |
| Efficacy of Albumin Therapy With Standard Medical Treatment (SMT) as Compared to Standard Medical Treatment (SMT) in Improving Patient Survival and Immune Modulation in Patients With Acute on Chronic Liver Failure (ASIA Trial). Albumin, Standard Medical Treatment - Acute on Chronic Liver Failure | Not applicable | Unknown | Institute of Liver and Biliary Sciences, India | 200 | 2018-09-10 | 2020-04-08 |
Showing 20 of 34. Sign in to see all of them.
Acute-On-Chronic Liver Failure (34) · Liver Cirrhosis (3) · Liver Failure, Acute (3) · Fibrosis (2) · Hepatitis B (2) · Sepsis (2) · Burns (1) · Communicable Diseases (1) · Crigler-Najjar Syndrome (1) · Cytokine Release Syndrome (1) · Disease (1) · Drug Overdose (1) · Hepatic Encephalopathy (1) · Hepatitis, Alcoholic (1) · Liver Failure (1)
Digestive System Diseases (34) · Hepatic Insufficiency (34) · Liver Diseases (34) · Liver Failure (33) · Liver Failure, Acute (31) · Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Infections (4) · Hepatitis (3) · Blood-Borne Infections (2) · Brain Diseases (2) · Brain Diseases, Metabolic (2) · Central Nervous System Diseases (2) · Chemically-Induced Disorders (2) · Communicable Diseases (2)
Albumins (5) · Terlipressin (3) · Carvedilol (2) · Tenofovir (2) · Blood Specimen Collection (1) · Crystalloid Solutions (1) · Fecal Microbiota Transplantation (1) · Granulocyte Colony-Stimulating Factor (1) · Lactulose (1) · Meropenem (1) · Midodrine (1) · Nordefrin (1) · Norepinephrine (1) · Nutritional Status (1) · Plasma Exchange (1)
Institute of Liver and Biliary Sciences, India (18) · Cellaion SA (2) · Govind Ballabh Pant Hospital (2) · Post Graduate Institute of Medical Education and Research, Chandigarh (2) · All India Institute of Medical Sciences (1) · Assistance Publique - Hôpitaux de Paris (1) · Beijing 302 Hospital (1) · CytoSorbents Europe GmbH (1) · CytoSorbents, Inc (1) · Mexbrain (1) · Nanfang Hospital, Southern Medical University (1) · Qin Ning (1) · Sir Ganga Ram Hospital (1) · Yaqrit Ltd (1)
India (24) · France (4) · Germany (4) · Spain (4) · Austria (3) · Belgium (3) · China (3) · Poland (3) · Bulgaria (2) · Denmark (2) · Italy (2) · Estonia (1) · Latvia (1) · Lithuania (1) · North Macedonia (1)
Anil Arora, M.D (1) · Banwari Agarwal, Dr (1) · Dr Ashok Choudhary, DM (1) · Dr Juned Ahmad, MD (1) · Dr Sumeet Kainth, MD (1) · Dr Vinod Arora, MD (1) · Hanmin Li (1) · Jianchun Guo (1) · Jiefei Wang (1) · Jinmo Tang (1) · Kewei Sun (1) · Lin Wang (1) · Man Gong, Doctor (1)
PMID 21294143, PMID 22119930, PMID 30589495, PMID 31077821, PMID 31541422, PMID 31849085, PMID 37268222, PMID 39500494, PMID 41180104