6 completed, 3 unknown, 1 enrolling by invitation, 1 not yet recruiting. 5 Phase 4, 2 Phase 1, 2 Phase 2, 2 Phase 3, 1 Early Phase 1.
Follow Acetaminophen: new trials by email Literature Review of Acetaminophen trials Research Report on Acetaminophen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intravenous Acetaminophen to Reduce Post-operative Opioid Consumption IV Acetaminophen - Post Operative Analgesia, Opioid Consumption, Postoperative | Phase 4 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 140 | 2025-04-28 | 2025-04-11 |
| Alternatives to Dental Opioid Prescribing After Tooth Extraction Multicomponent intervention, Usual care - Analgesics, Opioid, Acute Pain | Not applicable | Enrolling by invitation | Douglas Oyler | 38159 | 2024-04-16 | 2026-09-10 |
| Comparison of the Efficacy of Paracetamol and Ibuprofen in the Management of Fever in Sepsis Patients Acetaminophen, Ibuprofen - Sepsis, Acetaminophen | Phase 4 | Completed | Ankara City Hospital Bilkent | 113 | 2023-10-31 | 2025-02-04 |
| Acetaminophen Before Surgery Lowers Postop Pain in Pediatric Solid Tumor Patients (ERAS) Acetaminophen, Sterilized water - Analgesic, Enhanced Recovery After Surgery | Phase 1 | Completed | Nanjing Children's Hospital | 182 | 2023-05-15 | 2025-07-31 |
| Efficacy and Safety of Acetaminophen in Postoperative Pain Management of Infants Acetaminophen, Sterilized water - Analgesic, Enhanced Recovery After Surgery | Phase 1 | Completed | Nanjing Children's Hospital | 220 | 2022-09-14 | 2024-07-10 |
| Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose Intravenous infusion of N-acetylcysteine, Intravenous infusion of Fomepizole (4-MP) - Acetaminophen, Drug Overdose | Phase 2 | Terminated | Richard Dart, MD, PhD | 29 | 2022-09-12 | 2025-11-25 |
| Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen Acetaminophen, NACL 0.9% - Patency of the Ductus Arteriosus, Acetaminophen | Phase 2 / Phase 3 | Completed | Institut National de la Santé Et de la Recherche Médicale, France | 804 | 2020-10-29 | 2026-03-16 |
| Screening of Susceptibility Genes for APAP Induced Drug Induced LIver Injury in ChiNese Population: a Case-control Study genetic polymorphism - Acetaminophen, Drug-Induced Liver Injury | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 339 | 2020-08-31 | 2025-02-26 | |
| Improving Post-Operative Pain and Recovery in Gynecologic Surgery Rectal acetaminophen, Intravenous acetaminophen - Postoperative Pain, Opioid Use | Phase 4 | Completed | Aultman Health Foundation | 40 | 2019-12-23 | 2022-01-20 |
| A Comparison of IV Versus PO Acetaminophen Postoperatively for Opioid Consumption After Cesarean Section Acetaminophen, Placebos - Postoperative Pain, Cesarean Section | Phase 4 | Unknown | Main Line Health | 130 | 2019-08-22 | 2020-02-28 |
| Impact of Acetaminophen on Postoperative Delirium Elderly Patients After Non-cardiac Surgery Acetaminophen, Sufentanil - Acetaminophen, Delirium in Old Age | Early Phase 1 | Unknown | Xiangya Hospital of Central South University | 164 | 2019-02-15 | 2019-03-08 |
| Acetaminophen Given Per Os and Intravenous in Sinus Surgery Acetaminophen - Acetaminophen | Phase 3 | Unknown | Massachusetts Eye and Ear Infirmary | 124 | 2018-03-28 | 2019-04-10 |
| Intravenous Versus Oral Acetaminophen in Primary Total Hip Arthroplasty Intravenous acetaminophen, Oral acetaminophen - Osteoarthritis, Acetaminophen | Phase 4 | Completed | Duke University | 81 | 2017-03-14 | 2021-03-09 |
Pain, Postoperative (5) · Agnosia (2) · Chemical and Drug Induced Liver Injury (2) · Acute Pain (1) · Delirium (1) · Drug Overdose (1) · Ductus Arteriosus, Patent (1) · Fever (1) · Liver Failure (1) · Neoplasms (1) · Osteoarthritis (1) · Pain (1) · Patient Satisfaction (1) · Sepsis (1) · Vomiting (1)
Pathological Conditions, Signs and Symptoms (8) · Signs and Symptoms (8) · Neurologic Manifestations (7) · Pathologic Processes (6) · Pain (5) · Postoperative Complications (5) · Chemically-Induced Disorders (2) · Digestive System Diseases (2) · Drug-Related Side Effects and Adverse Reactions (2) · Liver Diseases (2) · Mental Disorders (2) · Nervous System Diseases (2) · Neurobehavioral Manifestations (2) · Perceptual Disorders (2) · Poisoning (2)
Acetaminophen (9) · 4-methylpiperazine-2,6-dione (1) · Ibuprofen (1) · Polymorphism, Genetic (1) · Sodium Chloride (1) · Sufentanil (1)
Nanjing Children's Hospital (2) · Ankara City Hospital Bilkent (1) · Aultman Health Foundation (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1) · Douglas Oyler (1) · Duke University (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Main Line Health (1) · Massachusetts Eye and Ear Infirmary (1) · Richard Dart, MD, PhD (1) · The First Affiliated Hospital with Nanjing Medical University (1) · Xiangya Hospital of Central South University (1)
United States (6) · China (4) · Belgium (1) · Canada (1) · Denmark (1) · Estonia (1) · Finland (1) · France (1) · Hungary (1) · Ireland (1) · Italy (1) · Norway (1) · Portugal (1) · Sweden (1) · Switzerland (1)
Dmitri Chamchad, MD (1) · Douglas R Oyler, PharmD (1) · Franck Vandenbroucke-Menu, MD (1) · Iuliu Fat, MD (1) · Jingsong Zhang, professor (1) · Marcia V Rojas Ramirez, DDS (1) · Richard Dart, MD, PhD (1) · Robert Day, MD (1) · Weibing Tang (1)
PMID 22524979, PMID 37681263, PMID 37978159, PMID 39578300, PMID 39948605, PMID 40678377, PMID 40889095, PMID 41657425, PMID 41697673, PMID 42028138
1UG3DE032621-01 (1), 2019 (1), 2025 (1), 4UH3DE032621-02 (1)