9 completed. 9 Phase 2, 5 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 9 |
| Phase 1 | 5 | Completed 5 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fibrosis-Modulating Effects of Metformin and Pirfenidone in Oral Submucous Fibrosis Metformin Hydrochloride 500Mg Tablet, Pirfenidone (PFD), Beclomaethasone and Vitamin E - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 45 | 2025-04-07 | 2026-02-03 |
| To Observe Haemodynamic Parameters Including, Heart Rate, Blood Pressure, Respiratory Rate , and Oxygen Saturation, With or Without Giving Reversal Agent on Extubation, in Patients Receiving Single Shot of Atracurium , and to Observe Post Operative Residual Paralysis and Airway Reflexes in PACU. Placebo drug ( normal saline ), neostigmine (reversal agent) - Tachycardia, Hypertension | Phase 1 / Phase 2 | Completed | Ziauddin University | 100 | 2025-03-12 | 2025-07-31 |
| Effect of Magnesium Sulfate on Hemodynamics on Laparoscopic Cholecystectomy Patients Placebo, Magnesium - Hemodynamics Instability, Pain After Surgery | Phase 1 / Phase 2 | Completed | Ziauddin University | 60 | 2025-01-06 | 2026-09-02 |
| Metformin Repurposing in Oral Submucous Fibrosis: Unveiling In Vitro Signaling Pathways, Progressing to Clinical Trial Metformin Hydrochloride, betamethasone dipropionate, Pentoxifylline - Oral Submucous Fibrosis | Phase 1 / Phase 2 | Completed | Ziauddin University | 30 | 2024-08-12 | 2025-05-02 |
| Misoprostol for NASH Misoprostol, Placebo - NASH | Phase 2 | Completed | Ziauddin University | 50 | 2022-07-01 | 2023-04-07 |
| Comparative Evaluation of Propolis Mouthwash With 0.2% Chlorhexidine Mouthwash in Improving the Periodontitis Propolis mouthwash, Chlorhexidine mouthwash - Periodontal Diseases | Phase 2 | Completed | Ziauddin University | 102 | 2022-02-02 | 2023-05-23 |
| Saccharomyces Cerevisiae for Irritable Bowel Syndrome Saccharomyces cerevisiae - Irritable Bowel Syndrome | Phase 1 / Phase 2 | Completed | Ziauddin University | 30 | 2021-03-01 | 2022-12-07 |
| Efficacy of PRF and MTA as Compared to Calcium Hydroxide for Pulpotomy in Human Irreversibly Inflamed Permanent Teeth Calcium hydroxide, MTA, PRF - Pulpitis - Irreversible, Tooth Decay | Phase 2 | Completed | Liaquat College of Medicine and Dentistry | 114 | 2019-08-28 | 2022-08-17 |
| ADDITION OF BISMUTH TO THE STANDARD TRIPLE THERAPY FOR HELICOBACTER PYLORI ERADICATION ARM A Triple therapy for helicobacter pylori, ARM B Quadruple therapy for helicobacter pylori - Helicobacter Pylori Infection | Phase 2 | Completed | Ziauddin University | 196 | 2018-06-01 | 2019-05-30 |
Oral Submucous Fibrosis (2) · Camurati-Engelmann Syndrome (1) · Delayed Emergence from Anesthesia (1) · Dental Caries (1) · Hypertension (1) · Hyperventilation (1) · Hypoxia (1) · Irritable Bowel Syndrome (1) · Pain (1) · Periodontal Diseases (1) · Pneumoperitoneum (1) · Postoperative Nausea and Vomiting (1) · Tachycardia (1)
Metformin (2) · Betamethasone Valerate (1) · Calcium Hydroxide (1) · Magnesium (1) · Magnesium Sulfate (1) · Misoprostol (1) · Neostigmine (1) · Pemetrexed (1) · Pentoxifylline (1) · Saline Solution (1) · Tablets (1) · Vitamin E (1) · betamethasone-17,21-dipropionate (1) · pirfenidone (1)
Pakistan (9)
Mehreen Siyal, MBBS, FCPS-1 (2) · Asma Abdus Salam, Consultant anaesthesiology (1) · Dr Asma A Salam, MBBS, FCPS (1) · Syeda M. Waqar, M.Phil (1)
PMID 10492412, PMID 10793602, PMID 12717123, PMID 1356374, PMID 17513629, PMID 17893459, PMID 19617379, PMID 20576632, PMID 22091288, PMID 22096279, PMID 23372884, PMID 23904932, PMID 25885838, PMID 28390753, PMID 29261883, PMID 30573962, PMID 31303716, PMID 31472446, PMID 31862004, PMID 33008091, PMID 34007848, PMID 34667360, PMID 35410255, PMID 3605668, PMID 36552855, PMID 37139057, PMID 38183081, PMID 38844374, PMID 6161627, PMID 9366929, PMID 9793671, PMID 9797517