65 completed, 16 active not recruiting, 14 unknown, 12 terminated. 52 Phase 2, 42 Phase 1, 16 Not applicable, 9 Phase 3, 4 Phase 4.
Follow Carcinoma, Medullary: new trials by email Literature Review of Carcinoma, Medullary trials Research Report on Carcinoma, Medullary
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| STAGE-MTC Trial Thyroid Lobectomy With Ipsilateral Central Neck Dissection Biospecimen Collection, FDG-Positron Emission Tomography and Computed Tomography Scan, Ga-68 PET/CT Scan - Thyroid Gland Medullary Carcinoma | Not applicable | Not yet recruiting | Jonsson Comprehensive Cancer Center | 100 | 2027-09-02 | 2026-10-19 |
| Enfortumab Vedotin for the Treatment of Unresectable or Metastatic Radioiodine Refractory Differentiated Thyroid Cancer, Anaplastic Thyroid Cancer, Medullary Thyroid Cancer, or NUT Carcinoma Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Differentiated Thyroid Gland Carcinoma, Metastatic NUT Carcinoma | Phase 2 | Not yet recruiting | Northwestern University | 56 | 2027-05-05 | 2026-10-07 |
| 211At-MABG in Adults With Advanced Neuroendocrine Cancers 1 MBq/k of 211At-MABG Fractionated, 2 MBq/k1 of 211At-MABG Fractionated, 4 MBq/k of 211At-MABG Fractionated - Pheochromocytoma, Paraganglioma | Phase 1 | Not yet recruiting | University of Pennsylvania | 16 | 2026-12-01 | 2026-10-07 |
| A Comparison of [68Ga]DOTATATE and [18F]AmBF3TATE for the Staging and Assessment of Neuroendocrine Malignancies 68Ga-DOTATATE PET/CT, 18F-AmBF3-TATE PET/CT - Neuroendocrine Tumors, NET, Pheochromocytoma/Paraganglioma | Not yet recruiting | British Columbia Cancer Agency | 60 | 2026-11-30 | 2026-10-06 | |
| Stromal Desmoplastic Reaction as a Predictive Factor for Lymph Node Metastasis in Medullary Thyroid Cancer lobectomy with lymph node dissection - Medullary Thyroid Carcinoma | Not yet recruiting | Aristotle University Of Thessaloniki | 74 | 2026-09-30 | 2026-10-01 | |
| Thyroid Health Outcomes Registry for Surgery Thyroid Diseases, Thyroid Neoplasms | Not yet recruiting | Pirogov Russian National Research Medical University | 3000 | 2026-09-01 | 2026-09-10 | |
| Study of SNH-118110 in Advanced Solid Tumors SNH-118110 Soft Capsules - Solid Tumors | Phase 1 | Not yet recruiting | ScinnoHub Pharmaceutical Co., Ltd. | 240 | 2026-06-26 | 2026-06-16 |
| Database Linkage Study to Evaluate the Risk of Medullary Thyroid Carcinoma No treatment given - Medullary Thyroid Carcinoma | Enrolling by invitation | Novo Nordisk A/S | 93600000 | 2025-12-31 | 2026-08-04 | |
| Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors 225Ac-ETN029, 111In-ETN029 - Small Cell Lung Carcinoma, Large Cell Neuroendocrine Carcinoma of the Lung | Phase 1 | Recruiting | Novartis Pharmaceuticals | 116 | 2025-10-16 | 2026-09-22 |
| Radiation Combined With BIspecific T-Cell Engager in DLL3 Expressing Tumors Tarlatamab, Concurrent Radiation Therapy, Sequential Radiation therapy - Melanoma, Medullary Thyroid Cancer | Phase 1 / Phase 2 | Recruiting | University of Arizona | 30 | 2025-09-08 | 2026-10-06 |
| CTR-FAPI-guided Precision Surgery for Newly Diagnosed MTC 68Ga-CTR-FAPI PET-CT guided surgery, investigator choice of surgery - Medullary Thyroid Carcinoma | Phase 3 | Recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 150 | 2025-08-25 | 2026-02-03 |
| Cultural Adaptation of an Educational Tool in Medullary Thyroid Cancer Interviews - Medullary Thyroid Cancer (MTC), Cultural Adaptation | Recruiting | M.D. Anderson Cancer Center | 40 | 2025-08-15 | 2026-09-25 | |
| A Prospective Cohort Study of Pralsetinib or Anlotinib in the Treatment of Locally Advanced and/or Metastatic Medullary Thyroid Carcinoma With RET Gene Mutations Medullary Thyroid Cancer (MTC) | Not yet recruiting | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 40 | 2025-08-01 | 2025-07-03 | |
| Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers Computed Tomography, Fludeoxyglucose F-18, Gallium Ga 68 FAPi-46 - Anal Carcinoma, Bladder Carcinoma | Phase 1 | Active not recruiting | Jonsson Comprehensive Cancer Center | 30 | 2025-08-01 | 2026-10-20 |
| Research on the Application of 68Ga-DOTA-CCK-FS PET/CT in MTC 68Ga-DOTA-CCK-FS PET/CT - Medullary Thyroid Carcinoma | Not applicable | Recruiting | Luo Yaping | 30 | 2025-05-10 | 2025-08-24 |
| A Detailed Look At What Patients Experience In Medullary Thyroid Cancer Clinical Study Medullary Thyroid Cancer | Not yet recruiting | Power Life Sciences Inc. | 500 | 2024-11-01 | 2023-10-12 | |
| PET-TC in Thyroid Evaluation clinical practice drug treatment - Medullary Thyroid Carcinoma, Hyperparathyroidism | Enrolling by invitation | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 418 | 2024-10-14 | 2025-02-28 | |
| Predictive Factors for Medullary Thyroid Cancer Aggressiveness Total Thyroidectomy - Medullary Thyroid Cancer | Completed | Aristotle University Of Thessaloniki | 500 | 2024-03-01 | 2025-01-03 | |
| Treatment of Advanced Endocrine Tumor With Iindividualized mRNA Neoantigen Vaccine (mRNA-0523-L001) individualized mRNA neoantigen vaccine (mRNA-0523-L001) - Adrenal Cortical Carcinoma, Medullary Thyroid Cancer | Not applicable | Recruiting | Shanghai Jiao Tong University School of Medicine | 21 | 2024-01-13 | 2026-04-09 |
| Trial of Lu-177 DOTATATE (Lutathera®) in Unlicensed Indications Lu-177 DOTATATE (Lutathera®) - Bronchial and Thymic Neuroendocrine Tumour, Paraganglioma/ Phaeochromocytoma | Phase 2 | Not yet recruiting | University College, London | 110 | 2023-12-18 | 2023-12-07 |
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Thyroid Neoplasms (49) · Thyroid Cancer, Papillary (27) · Adenocarcinoma, Follicular (21) · Carcinoma, Non-Small-Cell Lung (20) · Head and Neck Neoplasms (20) · Thyroid Carcinoma, Anaplastic (19) · Colonic Neoplasms (15) · Pheochromocytoma (15) · Breast Neoplasms (13) · Carcinoma, Hepatocellular (12) · Salivary Gland Neoplasms (12) · Lung Neoplasms (11) · Pancreatic Neoplasms (11) · Colorectal Neoplasms (10)
Neoplasms, Ductal, Lobular, and Medullary (141) · Adenocarcinoma (140) · Carcinoma (140) · Carcinoma, Neuroendocrine (140) · Neoplasms by Histologic Type (140) · Neoplasms, Germ Cell and Embryonal (140) · Neoplasms, Glandular and Epithelial (140) · Neoplasms, Nerve Tissue (140) · Neuroectodermal Tumors (140) · Neoplasms (131) · Neuroendocrine Tumors (131) · Neoplasms by Site (84) · Endocrine System Diseases (77) · Endocrine Gland Neoplasms (74) · Thyroid Diseases (47)
vandetanib (14) · cabozantinib (9) · selpercatinib (6) · Everolimus (5) · Sorafenib (5) · Magnetic Resonance Spectroscopy (4) · Capecitabine (3) · Specimen Handling (3) · pralsetinib (3) · Doxorubicin (2) · Gefitinib (2) · High-Energy Shock Waves (2) · Lymph Node Excision (2) · Octreotide (2) · Sunitinib (2)
National Cancer Institute (NCI) (20) · M.D. Anderson Cancer Center (7) · Genzyme, a Sanofi Company (6) · Eli Lilly and Company (4) · Exelixis (4) · Cancer Institute and Hospital, Chinese Academy of Medical Sciences (3) · European Organisation for Research and Treatment of Cancer - EORTC (3) · Jonsson Comprehensive Cancer Center (3) · Sanofi (3) · University of Pennsylvania (3) · Aristotle University Of Thessaloniki (2) · British Columbia Cancer Agency (2) · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. (2) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (2) · Hoffmann-La Roche (2)
United States (80) · Italy (19) · China (17) · France (16) · Canada (15) · Spain (15) · Germany (14) · Netherlands (13) · South Korea (12) · Belgium (10) · Poland (10) · United Kingdom (10) · Australia (9) · Switzerland (8) · Brazil (7)
Christof Rottenburger, Dr. med. (2) · Herbert K. Lyerly, MD (2) · Ravi A Madan, M.D. (2) · Agustin Garcia (1) · Annamaria Colao (1) · Annette Stemhagen, DrPH, FISPE (1) · Anthony W. Tolcher, MD (1) · Antonio Fojo, MD (1) · Antonio T Fojo, M.D. (1) · Arlene A. Forastiere, MD (1)
PMID 36657661, PMID 37934000, PMID 15999359, PMID 17405835, PMID 17985341, PMID 17985985, PMID 18596272, PMID 18854394, PMID 19372041, PMID 19602035, PMID 19735988, PMID 20145168, PMID 20739388, PMID 20851682, PMID 21358115, PMID 21367608, PMID 21606412, PMID 22025146, PMID 23489023, PMID 23676418, PMID 23766359, PMID 24002501, PMID 24050953, PMID 24617713, PMID 24848831, PMID 25086465, PMID 25117183, PMID 25810047, PMID 25900182, PMID 25972901, PMID 26462967, PMID 27169792, PMID 28473600, PMID 29020892, PMID 29045520, PMID 29187393, PMID 29192093, PMID 29572709, PMID 30002107, PMID 30297385, PMID 30450128, PMID 30637562, PMID 31401903, PMID 32372416, PMID 32475305, PMID 32538690, PMID 32846060, PMID 32846061, PMID 32849281, PMID 33179845
N01CM62207 (3), 2018 (2), 2019 (2), N01CM62205 (2), P30CA015083 (2), 2005 (1), 2016 (1), 2017 (1), 2023 (1), N01CM00070 (1), N01CM00099 (1), N01CM62201 (1), N01CM62202 (1), P30CA006516 (1), P30CA006973 (1)