5 completed, 3 unknown, 2 not yet recruiting, 1 recruiting. 5 Phase 2, 3 Not applicable, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Recruiting 1, Unknown 1 |
| Not applicable | 3 | Not yet recruiting 2, Completed 1 |
| Phase 3 | 2 | Completed 2 |
Follow Buruli Ulcer: new trials by email Literature Review of Buruli Ulcer trials Research Report on Buruli Ulcer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers A mobile app with AI functionality for diagnosing skin-related NTDs - Skin and Connective Tissue Diseases, Neglected Tropical Diseases | Not applicable | Not yet recruiting | Kenya Medical Research Institute | 2420 | 2026-05-01 | 2026-04-02 |
| Integrating Mental Health Into Neglected Tropical Disease Care in Ghana WHO Essential Care package for mental health and NTDs - Leprosy, Lymphatic Filariases | Not applicable | Not yet recruiting | Liverpool School of Tropical Medicine | 200 | 2025-11-01 | 2025-11-25 |
| Telacebec (T) Treatment in Adults With Buruli Ulcer (BU). (TREAT BU) Telacebec - Buruli Ulcer | Phase 2 | Recruiting | Barwon Health | 200 | 2024-07-09 | 2026-06-30 |
| Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy Standard [RC8]: rifampicin plus clarithromycin (RC) therapy for 8 weeks., Investigational [RCA4]: standard (RC) plus amoxicillin/clavulanate (A) for 4 weeks. - Buruli Ulcer | Phase 2 | Unknown | Fundacion Agencia Aragonesa para la Investigacion y Desarrollo (ARAID) | 140 | 2021-12-01 | 2024-05-16 |
| Treat Early and Broad: Thermotherapy of Buruli Ulcer Integrated Into WHO-recommended Wound Management in West Africa thermotherapy (application of heat): This part of the trial is on hold due to the Covid19-pandemia - Skin Ulcer, Buruli Ulcer | Unknown | University Hospital Heidelberg | 5000 | 2019-05-07 | 2023-01-04 | |
| Thermotherapy of Buruli Ulcer at Community Level in the Health District of Akonolinga Buruli Ulcer | Withdrawn | Swiss Tropical & Public Health Institute | 2019-01-01 | 2020-12-21 | ||
| Integrated Mapping of Skin-presenting Neglected Tropical Diseases in Liberia Leprosy, Buruli Ulcer | Completed | London School of Hygiene and Tropical Medicine | 56285 | 2018-06-14 | 2024-06-10 | |
| Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana Doxycycline - Mansonella Perstans Infection, Buruli Ulcer | Phase 2 | Completed | Kwame Nkrumah University of Science and Technology | 200 | 2014-10-01 | 2017-03-23 |
| Pathogenesis and Management of M. Ulcerans Disease, Buruli Ulcer Buruli Ulcer, Mycobacterium Ulcerans Disease | Unknown | Kwame Nkrumah University of Science and Technology | 400 | 2013-05-01 | 2017-03-23 | |
| WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8 Clarithromycin Extended Release, Streptomycin intramuscular injection - Mycobacterium Ulcerans Infection | Phase 2 / Phase 3 | Completed | University Medical Center Groningen | 310 | 2012-12-01 | 2019-09-26 |
| Timing of Surgical Intervention in Buruli Ulcer Patients Treated With Antibiotics surgical intervention on Buruli ulcer - Mycobacterium Ulcerans Disease, Buruli Ulcer | Not applicable | Completed | University Medical Center Groningen | 119 | 2011-09-01 | 2019-07-22 |
| BURULICO Drug Trial Study Protocol: RCT SR8/SR4+CR4, GHANA SR4 - switch to CR4 - Buruli Ulcer, Mycobacterium Ulcerans | Phase 2 / Phase 3 | Completed | University Medical Center Groningen | 151 | 2006-05-01 | 2010-06-30 |
Elephantiasis, Filarial (3) · Leprosy (3) · Yaws (3) · Neglected Diseases (2) · Onchocerciasis (2) · Coinfection (1) · Dipetalonema Infections (1) · Elephantiasis (1) · Hyperthermia (1) · Leishmaniasis, Cutaneous (1) · Mansonelliasis (1) · Mycetoma (1) · Scabies (1) · Skin Ulcer (1)
Actinomycetales Infections (12) · Bacterial Infections (12) · Bacterial Infections and Mycoses (12) · Gram-Positive Bacterial Infections (12) · Infections (12) · Mycobacterium Infections (12) · Mycobacterium Infections, Nontuberculous (12) · Skin Diseases (12) · Skin Ulcer (11) · Skin and Connective Tissue Diseases (11) · Filariasis (4) · Helminthiasis (4) · Nematode Infections (4) · Parasitic Diseases (4) · Pathological Conditions, Signs and Symptoms (4)
Clarithromycin (1) · Clavulanic Acid (1) · Doxycycline (1) · Hyperthermia, Induced (1) · Mental Health (1) · Therapeutics (1) · WW Domain-Containing Oxidoreductase (1) · telacebec (1)
University Medical Center Groningen (3) · Kwame Nkrumah University of Science and Technology (2) · Barwon Health (1) · Fundacion Agencia Aragonesa para la Investigacion y Desarrollo (ARAID) (1) · Kenya Medical Research Institute (1) · Liverpool School of Tropical Medicine (1) · London School of Hygiene and Tropical Medicine (1) · Swiss Tropical & Public Health Institute (1) · University Hospital Heidelberg (1)
Ghana (4) · Benin (3) · Australia (1) · Côte d’Ivoire (1) · Democratic Republic of the Congo (1) · Ethiopia (1) · Kenya (1) · Liberia (1) · Nigeria (1) · Senegal (1)
Alexander Y Debrah, PhD (1) · Annick Chauty, MD (1) · D Agossadou, MD (1) · Daniel O'Brien, MD (1) · Ellis Owusu Dabo, MBChB, PhD (1) · G Sopoh, MD PhD (1) · Gustavo H Penaloza, PhD (1) · Karsor Kollie, MSc (1) · Kingsley B Asiedu, MD, MPH (1) · Marija Stojkovic, MD (1) · R OC Johnson, MD PhD (1) · Rachel L Pullan, PhD (1) · Richard O Phillips, FWACP,FGCP (1)
PMID 27097163, PMID 20137805, PMID 22156855, PMID 28061905, PMID 29605498, PMID 30102705, PMID 31449522, PMID 32171422, PMID 35804454, PMID 36227839, PMID 36227844, PMID 38573915, PMID 42104494