29 completed, 9 unknown, 6 recruiting, 3 not yet recruiting. 18 Not applicable, 11 Phase 2, 8 Phase 1, 4 Phase 3, 4 Phase 4.
Follow Leprosy: new trials by email Literature Review of Leprosy trials Research Report on Leprosy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers A mobile app with AI functionality for diagnosing skin-related NTDs - Skin and Connective Tissue Diseases, Neglected Tropical Diseases | Not applicable | Not yet recruiting | Kenya Medical Research Institute | 2420 | 2026-05-01 | 2026-04-02 |
| Epidemiological, Clinical, Diagnostic, and Therapeutic Characteristics of Hansen's Disease in Costa Rica (2018-2025) Leprosy, Hansen's Disease | Not yet recruiting | Caja Costarricense de Seguro Social | 130 | 2026-05-01 | 2026-03-09 | |
| Accuracy of the Polymerase Chain Reaction of Ulnar Perineural Subcutaneous Aspirate Guided by Ultrasound for the Diagnosis and Monitoring of Leprosy Cure Ultrasound-Guided Ulnar Perineural Subcutaneous Aspirate - Leprosy, Leprosy Neuropathy | Not applicable | Recruiting | University of Brasilia | 108 | 2026-01-01 | 2026-04-07 |
| Integrating Mental Health Into Neglected Tropical Disease Care in Ghana WHO Essential Care package for mental health and NTDs - Leprosy, Lymphatic Filariases | Not applicable | Not yet recruiting | Liverpool School of Tropical Medicine | 200 | 2025-11-01 | 2025-11-25 |
| Leprosy Active Searching Trial in Brazil Implementing active-case finding strategies - Leprosy | Not applicable | Completed | Hospital Alemão Oswaldo Cruz | 323 | 2025-06-01 | 2026-08-04 |
| Auricular Electroacupuncture and Auricular Acupuncture With Health Education for Pain in Leprosy Auricular Electroacupuncture, Auricular Acupuncture, Health Education - Leprosy | Not applicable | Completed | Universidade Federal de Pernambuco | 16 | 2025-04-01 | 2026-10-07 |
| Trauma-Informed Motivational Interviewing in Rural Dwelling Samples Trauma-Informed Motivational Interviewing - Discrimination, Perceived | Not applicable | Recruiting | Alexandria University | 70 | 2025-03-01 | 2025-04-23 |
| Trial LEP-F1 + GLA-SE in Healthy Adult in Areas Endemic for Leprosy LepVax (2 μg LEP-F1 + 5 μg GLA-S): Low dose, LepVax (10 μg LEP-F1 + 5 μg GLA-SE): High dose, Placebo Comparator: Placebo - Leprosy | Phase 1 | Unknown | The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz) | 54 | 2025-01-02 | 2024-10-04 |
| Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients Dapsone - Leprosy, Mycobacterium Leprae Infection | Not applicable | Recruiting | South Valley University | 50 | 2024-12-20 | 2025-02-11 |
| TGF β 1 Expression Related Gene Polymorphism Measurement of TGF- β1 in leprosy patients - Leprosy | Unknown | Aswan University | 60 | 2024-07-10 | 2024-11-12 | |
| Phase 1b/2a Trial to Evaluate LEP-F1 + GLA-SE in Healthy Adults and Leprosy Patients LEP-F1 + GLA-SE, Placebo - Leprosy | Phase 1 / Phase 2 | Unknown | The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz) | 142 | 2024-02-01 | 2023-06-13 |
| Serum Irisin Level In Leprosy Patients Serum Irisin - Leprosy | Completed | Aswan University | 58 | 2024-01-01 | 2024-11-08 | |
| Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy BE-PEP Bedaquiline, SDR-PEP Rifampicin, BE-PEP Rifampicin - Leprosy | Phase 3 | Recruiting | Institute of Tropical Medicine, Belgium | 124000 | 2023-03-22 | 2026-05-19 |
| Methotrexate and Prednisolone Study in Erythema Nodosum Leprosum Methotrexate, Placebo, Prednisolone - Erythema Nodosum Leprosum | Not applicable | Active not recruiting | London School of Hygiene and Tropical Medicine | 550 | 2023-01-15 | 2025-09-10 |
| Efficacy and Tolerability of Adjunct Metformin for Multibacillary Leprosy Metformin, Placebo - Leprosy, Leprosy, Multibacillary | Phase 2 | Recruiting | Oxford University Clinical Research Unit Indonesia | 166 | 2022-10-01 | 2025-08-07 |
| Bedaquiline Enhanced Post ExpOsure Prophylaxis for Leprosy (Phase 2) BE-PEP (Bedaquiline), SDR-PEP, BE-PEP (Rifampicine) - Leprosy | Phase 2 | Completed | Institute of Tropical Medicine, Belgium | 313 | 2022-07-14 | 2024-08-28 |
| The Effects of Traditional Chinese Medicine Mouthwash Solutions on the Oral Health of Leprosy Patients Traditional Chinese Medicine mouthwash, Dilute 50 times of Traditional Chinese Medicine mouthwash - Leprosy, Hansen's Disease | Not applicable | Completed | Lo-Sheng Sanatorium | 41 | 2021-10-01 | 2024-03-13 |
| The Effect of "Jinchuang Ointment" (JCO) on the Treatment of Wounds in Patients With Hansen's Disease. "Jingchuang Ointment"(JCO), Regular Treatment - Leprosy, Hansen's Disease | Not applicable | Completed | Lo-Sheng Sanatorium | 20 | 2021-08-07 | 2024-03-13 |
| Novel Interventions and Diagnostic Tests for Leprosy Rifampin - Leprosy | Not applicable | Recruiting | Annemieke Geluk | 1100 | 2020-03-04 | 2025-09-10 |
| Epidemiology of Leprosy in French Guiana standardised exposure questionnaire - Hansen's Disease | Unknown | Centre Hospitalier de Cayenne | 368 | 2020-01-07 | 2021-09-01 |
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Leprosy, Multibacillary (5) · Leprosy, Lepromatous (4) · Buruli Ulcer (3) · Elephantiasis, Filarial (3) · Yaws (3) · Communicable Diseases (2) · Neglected Diseases (2) · Onchocerciasis (2) · Tuberculosis (2) · Acne Vulgaris (1) · Cerebral Palsy (1) · Disease (1) · Elephantiasis (1) · Health Education (1)
Actinomycetales Infections (52) · Bacterial Infections (52) · Bacterial Infections and Mycoses (52) · Gram-Positive Bacterial Infections (52) · Infections (52) · Mycobacterium Infections (52) · Mycobacterium Infections, Nontuberculous (52) · Pathological Conditions, Signs and Symptoms (11) · Pathologic Processes (6) · Disease Attributes (4) · Gram-Negative Bacterial Infections (4) · Nervous System Diseases (4) · Signs and Symptoms (4) · Skin Diseases (4) · Skin and Connective Tissue Diseases (4)
Cyclosporine (4) · Dapsone (4) · Prednisolone (4) · Rifampin (4) · Adrenal Cortex Hormones (3) · Clofazimine (3) · Low-Level Light Therapy (2) · Methotrexate (2) · bedaquiline (2) · Acupuncture, Ear (1) · Amitriptyline (1) · CC-11050 (1) · Counseling (1) · Exercise (1) · Health Promotion (1)
London School of Hygiene and Tropical Medicine (6) · Institute of Tropical Medicine, Belgium (4) · National Institute of Allergy and Infectious Diseases (NIAID) (3) · Aswan University (2) · Colorado State University (2) · Lo-Sheng Sanatorium (2) · The Immunobiological Technology Institute (Bio-Manguinhos) / Oswaldo Cruz Foundation (Fiocruz) (2) · University of Brasilia (2) · University of Sao Paulo (2) · Access to Advanced Health Institute (AAHI) (1) · Alexandria University (1) · Annemieke Geluk (1) · Caja Costarricense de Seguro Social (1) · Centre Hospitalier de Cayenne (1) · Chittagong Medical College (1)
Brazil (12) · Ethiopia (6) · United States (5) · Bangladesh (4) · Comoros (4) · Egypt (4) · Indonesia (4) · Nepal (3) · Philippines (3) · Taiwan (2) · China (1) · Colombia (1) · Costa Rica (1) · Democratic Republic of the Congo (1) · French Guiana (1)
Diana NJ Lockwood, MBChB (2) · Wei-Hung Hsu (2) · Younoussa Assoumani (2) · Abdallah Mahmoud Abdallah, Professor (1) · Abdul H Salim, MBBS (1) · Annemieke Geluk, PhD (1) · Arnold M Henson, MD (1) · Bertrand Cauchoix, MD (1) · Bouke C de Jong, MD,PhD (1) · Bouke de Jong, MD, PhD (1) · Claudio G Salgado, Dr (1) · Corey Casper, MD, MPH (1) · Daniel Andrade, PhD (1) · Diana Lockwood, MBChB (1)
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5UL1RR024982-02 (1)