31 completed, 7 recruiting, 3 unknown, 2 active not recruiting. 24 Not applicable, 11 Early Phase 1, 4 Phase 2, 4 Phase 4, 3 Phase 1.
Follow Vasodilation: new trials by email Literature Review of Vasodilation trials Research Report on Vasodilation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Acute Effect of Polyphenols Supplementation on Endothelial Function and Exercise Related Markers, in Physically Active Healthy Volunteers. Oral administration - Vasodilation, Exercise | Not applicable | Active not recruiting | Nexira | 38 | 2025-09-01 | 2026-04-13 |
| Effects of Lentil Protein Hydrolysate on Blood Pressure Control, Vascular Function and Exercise Performance Lentil protein hydrolysate, Placebo MCC micro-crystalline cellulose - Exercise, Blood Pressure | Not applicable | Recruiting | Nuritas Ltd | 48 | 2025-06-24 | 2025-12-16 |
| Vasodilator and Exercise Study for DMD (VASO-REx) Tadalafil, Placebo, Exercise Training - Duchenne Muscular Dystrophy, Duchenne Disease | Phase 2 | Recruiting | University of Florida | 50 | 2024-06-05 | 2026-05-15 |
| Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia Placebo, Propranolol, Gemtesa - Aging, Menopause | Early Phase 1 | Recruiting | University of Missouri-Columbia | 75 | 2024-06-03 | 2026-09-10 |
| Effect of Korean Red Ginseng Extract on Blood Flow in Healthy Adults Korean Red Ginseng Extract Powder 120 mg/tablet, Korean Red Ginseng Extract Powder 500 mg/tablet, Placebo - Cardiovascular Diseases, Blood Pressure Disorders | Not applicable | Completed | Korea Ginseng Corporation | 108 | 2024-01-31 | 2024-11-27 |
| Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences Phenylephrine Hydrochloride, Isoproterenol Hydrochloride, Norepinephrine Bitartrate - Vasoconstriction, Vasodilation | Phase 4 | Recruiting | University of Alberta | 30 | 2023-10-31 | 2026-01-08 |
| Effects of Betalains on Cardiovascular Health and Quality of Life Betalains, Placebo - Vascular Stiffness, Vasodilation | Not applicable | Completed | King's College London | 42 | 2023-10-30 | 2025-11-14 |
| Investigation of Endothelium-dependent Vasodilation in Human Gingiva Acetylcholine Chloride - Vasodilation, Oral Soft Tissue Conditions | Not applicable | Unknown | Semmelweis University | 80 | 2023-09-01 | 2024-06-12 |
| Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia Propranolol Pill, Placebo - Vasodilation, Hypoxia | Early Phase 1 | Completed | University of Missouri-Columbia | 31 | 2023-04-26 | 2025-09-15 |
| Sex Disparities in Hypoxic Vasodilation and Impact of Obesity Propranolol Hydrochloride, Isoproterenol, Phentolamine Mesylate - Obesity, Vasodilation | Early Phase 1 | Recruiting | University of Missouri-Columbia | 72 | 2023-03-14 | 2026-07-28 |
| Reducing Blood Pressure in Mid-life Adult Binge Drinkers Exercise Training, Alcohol Abstinence Intervention - Alcohol Drinking, Binge Drinking | Not applicable | Recruiting | The University of Texas at Arlington | 55 | 2022-11-21 | 2026-06-01 |
| Impact of Regional Vibration Application and Flow Mediated Dilation on Brachial Artery Hemodynamics Local Vibration Application Following Flow Mediated Dilation, Flow mediated dilation - Vasodilation, Diabetes Mellitus, Type 2 | Not applicable | Completed | Istanbul University | 80 | 2022-08-08 | 2023-03-01 |
| Sex Differences in Sympathetic Vascular Reactivity at High Altitude Sodium Nitroprusside, Phenylephrine Hydrochloride, Norepinephrine - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 17 | 2022-07-28 | 2024-09-19 |
| Effect of Topically-applied Milrinone or Nitroglycerin on Internal Mammary Artery Free Flow The topical application of a vasodilator on the LIMA graft - Internal Mammary Artery Syndrome, Vasodilation | Phase 3 | Completed | Damascus University | 46 | 2022-01-01 | 2026-03-19 |
| Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation Carbon dioxide breathing, Neurovascular Coupling, Human insulin - Healthy, Vasodilation | Early Phase 1 | Suspended | University of Missouri-Columbia | 65 | 2021-12-01 | 2025-12-19 |
| Effect of Ultimaster Stents Treated to the Most Dilated Coronary Vessels Nitrate - Vasodilation, Coronary Artery Disease | Not applicable | Unknown | Inha University Hospital | 400 | 2021-08-01 | 2021-06-18 |
| The Impact of Carbon Monoxide and Altitude on Vascular Function Carbon monoxide rebreathe, Sodium Nitroprusside, Phenylephrine Hydrochloride - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 19 | 2021-06-10 | 2022-05-25 |
| Sex Disparities in Hypoxic Sympatholysis and Impact of Obesity Cold Pressor Test - Obesity, Healthy | Early Phase 1 | Completed | University of Missouri-Columbia | 73 | 2020-12-09 | 2026-07-28 |
| Impact of Estradiol on Endothelial Function in Peri-Menopausal Women Estradiol (mylan or vivelle dot patch), Placebo - Perimenopause, Vasodilation | Phase 4 | Active not recruiting | University of Delaware | 80 | 2020-10-01 | 2026-04-29 |
| Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia. Phenylephrine Hydrochloride, Cold Pressor Test, Isocapnic Acute Hypoxia - Vasodilation, Vasoconstriction | Not applicable | Completed | University of Alberta | 14 | 2019-08-04 | 2022-10-31 |
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Aneurysm (46) · Obesity (6) · Cardiovascular Diseases (5) · Motor Activity (5) · Hypoxia (3) · Heart Diseases (2) · Hyperlipidemias (2) · Hypertension (2) · Alcohol Abstinence (1) · Alcohol Drinking (1) · Arterial Occlusive Diseases (1) · Binge Drinking (1) · Cardiac Output, High (1) · Cardiac Output, Low (1) · Coronary Artery Disease (1)
Vascular Diseases (46) · Cardiovascular Diseases (41) · Pathological Conditions, Signs and Symptoms (14) · Signs and Symptoms (12) · Nutritional and Metabolic Diseases (10) · Behavior (6) · Body Weight (6) · Nutrition Disorders (6) · Overnutrition (6) · Overweight (6) · Metabolic Diseases (5) · Nervous System Diseases (4) · Glucose Metabolism Disorders (3) · Heart Diseases (3) · Signs and Symptoms, Respiratory (3)
Nitroprusside (5) · Phenylephrine (5) · Propranolol (5) · Acetylcholine (4) · Exercise (4) · Nitroglycerin (3) · Norepinephrine (3) · Phentolamine (3) · Angiotensin-Converting Enzyme Inhibitors (2) · Bosentan (2) · Isoproterenol (2) · 1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (1) · Adenosine Triphosphate (1) · Administration, Oral (1) · Adrenergic beta-Antagonists (1)
University of Missouri-Columbia (6) · University of Alberta (4) · University of Edinburgh (4) · Colorado State University (2) · King's College London (2) · Radboud University Medical Center (2) · Semmelweis University (2) · The University of Texas at Arlington (2) · Damascus University (1) · Hermina Heart Center Kemayoran (1) · Inha University Hospital (1) · Insel Gruppe AG, University Hospital Bern (1) · Istanbul University (1) · Korea Ginseng Corporation (1) · Laval University (1)
United States (15) · United Kingdom (10) · Canada (5) · Brazil (2) · France (2) · Hungary (2) · Netherlands (2) · Australia (1) · Denmark (1) · Indonesia (1) · Italy (1) · Sweden (1) · Switzerland (1) · Syria (1) · Turkey (Türkiye) (1)
Sean van Diepen, MD, MSc (4) · Craig Steinback, PhD (3) · Jacqueline K Limberg, Ph.D. (3) · Frank Dinenno, PhD (2) · Gareth D Barnes, MBChB (2) · Amir H.S. Rafie, MD (1) · Ana Rodriguez-Mateos, PhD (1) · Antonio P Barretto, PhD (1) · Charles Couillard, Ph.D. (1) · Christoph C Ganter, M.D. (1) · Chueh-Lung Hwang, PhD (1) · Craig D Steinback, PhD (1) · Eric Benamo, MD (1) · Gerard Rongen, MD, PhD (1)
PMID 23519586, PMID 25099540, PMID 25179153, PMID 26192328, PMID 27207552, PMID 33992607, PMID 34111245, PMID 37464355, PMID 38366225, PMID 39485702, PMID 40066842, PMID 40465513
K99HL130339 (1), R00AA028537 (1), R00HL130339 (1), R01HL146558 (1), R21AR079755 (1)