9 completed, 8 unknown, 1 active not recruiting, 1 recruiting. 8 Not applicable, 3 Phase 3, 1 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 4, Unknown 3, Withdrawn 1 |
| Phase 3 | 3 | Unknown 2, Completed 1 |
| Phase 2 | 1 | Unknown 1 |
| Phase 4 | 1 | Active not recruiting 1 |
Follow Variceal Hemorrhage: new trials by email Literature Review of Variceal Hemorrhage trials Research Report on Variceal Hemorrhage
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Continuous Versus Bolus Infusion of Terlipressin for Portal Hypertension Related Bleeding in Liver Cirrhosis Terlipressin - Liver Cirrhosis, Portal Hypertension | Not applicable | Unknown | General Hospital of Shenyang Military Region | 40 | 2024-07-01 | 2024-02-23 |
| Prophylactic Antibiotics in Endoscopic Secondary Prevention of Gastroesophageal Variceal Bleeding No use of prophylactic antibiotics, Prophylactic Antibiotics - Cirrhosis, Liver, Hypertension, Portal | Not applicable | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 226 | 2024-05-25 | 2026-05-27 |
| Objective Scores in Variceal Bleeding Variceal Hemorrhage | Unknown | Assiut University | 85 | 2024-03-01 | 2024-03-22 | |
| Efficacy of Continuous Terlipressin Therapy After Endoscopic Variceal Ligation Terlipressin, 0.9% normal saline (NS) - Variceal Hemorrhage | Phase 3 | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 165 | 2023-09-01 | 2023-09-07 |
| Vonoprazan Efficacy to Prevent Post Variceal Band Ligation Ulcer Vonoprazan fumarate (Vonaspire), Pantoprazole 40mg, Placebo - Portal Hypertension, Variceal Hemorrhage | Phase 3 | Completed | Alexandria University | 284 | 2022-02-15 | 2024-08-30 |
| Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy Rotational thromboelastometry - Acute on Chronic Liver Failure, Variceal Hemorrhage | Not applicable | Completed | Post Graduate Institute of Medical Education and Research, Chandigarh | 262 | 2021-11-15 | 2026-10-06 |
| Macro and Microcirculatory Effects of the Combination of Norepinephrine and Octreotide for the Treatment of Cirrhotic Patients With Hemorrhagic Shock Octreotide Injection - Haemorrhagic Shock, Variceal Hemorrhage | Not applicable | Withdrawn | Centre Hospitalier Universitaire, Amiens | 2021-09-01 | 2023-02-09 | |
| Risk Prediction of Bleeding in Liver Cirrhosis by Combi-elastography Liver Cirrhosis, Gastroesophageal Varices | Unknown | Chinese PLA General Hospital | 300 | 2020-12-31 | 2021-01-19 | |
| Spleen Stiffness Combined With Liver Stiffness Measured by 2D-SWE for the Screening of High-risk Varices in Compensated Advanced Chronic Liver Disease (CHESS2004) Esophagogasrtoduodendoscopy, spleen stiffness measurement and liver stiffness measurement. - Compensated Advanced Chronic Liver Disease, Variceal Hemorrhage | Completed | Hepatopancreatobiliary Surgery Institute of Gansu Province | 381 | 2020-09-08 | 2024-09-05 | |
| HVPG-Guided Therapy vs Carvedilol Plus Endotherapy for the Prevention of Esophageal Variceal Rebleeding in Cirrhotic Patients Transjugular intrahepatic portosystemic shunt, Carvedilol, Endoscopic variceal ligation - Liver Cirrhoses, Variceal Hemorrhage | Not applicable | Unknown | Air Force Military Medical University, China | 220 | 2020-06-01 | 2020-02-05 |
| TIPS vs. NSBB Plus Endotherapy for the Prevention of Variceal Rebleeding in NSBB Non-responders of Primary Prophylaxis Transjugular intrahepatic portosystemic shunts, Nonselective β-blocker (NSBB)+ endoscopic band ligation (EBL) - Variceal Hemorrhage, TIPS | Not applicable | Unknown | Air Force Military Medical University, China | 114 | 2020-06-01 | 2020-02-05 |
| Heparin Like Effect in Acute Variceal Bleeding SONOCLOT, coagulation factor assays for VIII/X, XIII, TPA/ PAI - Coagulation Disorder, Cirrhosis, Liver | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 75 | 2019-11-01 | 2021-09-28 | |
| Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial. Carvedilol, Placebo - Cirrhosis, Liver, Portal Hypertension | Phase 4 | Active not recruiting | King's College Hospital NHS Trust | 763 | 2019-04-01 | 2026-05-01 |
| Terlipressin on Effect of Renal Function in Cirrhotic Patients With Acute Gastrointestinal Hemorrhage Terlipressin, Somatostatin, Octreotide - Variceal Hemorrhage, Cirrhosis, Liver | Completed | General Hospital of Shenyang Military Region | 1682 | 2019-03-01 | 2019-07-05 | |
| Propranolol, Carvedilol and Rosuvastatin in the Prevention of Variceal Bleeding in Cirrhotic Portal Hypertension Propranolol, Carvedilol, Rosuvastatin - Cirrhosis, Portal Hypertension | Phase 2 / Phase 3 | Unknown | Universidade Federal do Rio de Janeiro | 80 | 2019-01-25 | 2019-05-14 |
| Outcome After TIPS no intervention - retrospective analyses - Hypertension, Portal, Liver Cirrhosis | Completed | Medical University of Graz | 158 | 2018-03-23 | 2020-05-15 | |
| VICIS - Vienna Cirrhosis Study Liver Cirrhosis, Portal Hypertension | Recruiting | Medical University of Vienna | 10000 | 2017-02-01 | 2025-09-25 | |
| RCT to Determine the Efficacy of Combining Hemospray With Medical Treatment in Acute Variceal Bleeding Hemospray, Octreotide, Blood transfusion - Variceal Hemorrhage | Not applicable | Completed | Theodor Bilharz Research Institute | 105 | 2014-11-01 | 2017-11-14 |
| Clinical Evaluation of Hemospray in Hemostasis of Active Variceal Bleeding Hemospray - Variceal Hemorrhage | Not applicable | Completed | Theodor Bilharz Research Institute | 30 | 2013-01-01 | 2014-12-30 |
| Long-term Follow-up of HALT-C Sustained Virological Responders Hepatitis C, Hepatocellular Carcinoma | Completed | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | 140 | 2009-01-15 | 2019-12-17 |
Liver Cirrhosis (10) · Hypertension, Portal (7) · Esophageal and Gastric Varices (3) · Ascites (2) · Acute-On-Chronic Liver Failure (1) · Carcinoma, Hepatocellular (1) · Death (1) · Fibrosis (1) · Hemorrhage (1) · Hemostatic Disorders (1) · Hepatic Encephalopathy (1) · Hepatitis C (1) · Shock, Hemorrhagic (1)
Digestive System Diseases (14) · Liver Diseases (14) · Pathologic Processes (13) · Pathological Conditions, Signs and Symptoms (13) · Fibrosis (10) · Esophageal Diseases (3) · Gastrointestinal Diseases (3) · Hepatic Insufficiency (2) · Liver Failure (2) · Adenocarcinoma (1) · Blood-Borne Infections (1) · Brain Diseases (1) · Brain Diseases, Metabolic (1) · Carcinoma (1) · Cardiovascular Diseases (1)
Carvedilol (3) · Octreotide (3) · Terlipressin (3) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (1) · Anti-Bacterial Agents (1) · Blood Transfusion (1) · Ceftriaxone (1) · Combined Modality Therapy (1) · Pantoprazole (1) · Portasystemic Shunt, Transjugular Intrahepatic (1) · Propranolol (1) · Rosuvastatin Calcium (1) · Saline Solution (1) · Somatostatin (1)
Post Graduate Institute of Medical Education and Research, Chandigarh (3) · Air Force Military Medical University, China (2) · General Hospital of Shenyang Military Region (2) · Theodor Bilharz Research Institute (2) · Alexandria University (1) · Assiut University (1) · Centre Hospitalier Universitaire, Amiens (1) · Chinese PLA General Hospital (1) · Hepatopancreatobiliary Surgery Institute of Gansu Province (1) · King's College Hospital NHS Trust (1) · Medical University of Graz (1) · Medical University of Vienna (1) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Universidade Federal do Rio de Janeiro (1)
China (5) · Egypt (3) · India (3) · Austria (2) · Belgium (2) · Brazil (1) · France (1) · United Kingdom (1) · United States (1)
Chao Liu, MD (1) · Chuxiao Shao, MD (1) · Fengmei Wang, MD (1) · Guo Zhang, MD (1) · Jacques Deviere, PHD (1) · Jun Tie, M.D.,Ph.D. (1) · Linxue Qian, MD (1) · Marc G Ghany, M.D. (1) · Mark McPhail (1) · Meng Xue, PhD (1) · Mostafa Ibrahim, MD (1) · Ping Liang, Doctor (1) · RK Dhiman, MD DM (1) · Sameh Lashen, MD (1)
PMID 22366180, PMID 24120338, PMID 26937932, PMID 29730601, PMID 32088712, PMID 32358998, PMID 32860184, PMID 33000389, PMID 33075344, PMID 33289910, PMID 35066090, PMID 35261130, PMID 35808889, PMID 35822301, PMID 35984611, PMID 36152767, PMID 36481475, PMID 36873421, PMID 36881247, PMID 37035457, PMID 37469291, PMID 37484210, PMID 37605068, PMID 38125301, PMID 38332428, PMID 39708052, PMID 40467020, PMID 40899194, PMID 41077886, PMID 41194563, PMID 41551411, PMID 41816677, PMID 42174757, PMID 42309430, PMID 42462822, PMID 42759696, PMID 42789231