40 completed, 5 unknown, 3 terminated, 2 recruiting. 53 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 53 | Completed 40, Unknown 5, Terminated 3, Recruiting 2, Withdrawn 2, Not yet recruiting 1 |
Follow Type 1 Diabetes: new trials by email Literature Review of Type 1 Diabetes trials Research Report on Type 1 Diabetes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D) Insulin, DEXCOM Continuous Glucose Monitor - Pregnancy, High Risk, Type 1 Diabetes | Phase 4 | Recruiting | Ohio State University | 44 | 2026-02-25 | 2026-04-29 |
| Can the Addition of Pioglitazone to SGLT2 Inhibitor in Type 1 Diabetic Patients Amplify the Decrease in HbA1c and Prevent the Increase in Plasma Ketone Concentration? Dapagliflozin (DAPA), Pioglitazone 45 mg, Placebo - Type 1 Diabetes | Phase 4 | Not yet recruiting | Dasman Diabetes Institute | 60 | 2025-09-15 | 2025-08-29 |
| Efficacy of Dapagliflozin in Early Diabetic Nephropathy in Type 1 Diabetes dapagliflozin, ACE inhibitor - Diabetic Kidney Disease, Type 1 Diabetes | Phase 4 | Unknown | The First Affiliated Hospital with Nanjing Medical University | 54 | 2024-07-01 | 2024-08-01 |
| Effectiveness of Empagliflozin Added to Automated Insulin Delivery (AID) Systems in Adults With Type 1 Diabetes With Sub-optimal Glycemic Outcomes Empagliflozin, Placebo - Type 1 Diabetes | Phase 4 | Unknown | McGill University Health Centre/Research Institute of the McGill University Health Centre | 46 | 2024-04-02 | 2024-08-09 |
| Comparative Efficacy of a Two Daily Mixed Insulin Injection Versus a Basal-bolus Scheme With Human Insulin premix insulin human isophane suspension and insulin human, Humulin N plus Humulin R - Type 1 Diabetes | Phase 4 | Completed | Université NAZI BONI | 22 | 2023-06-15 | 2024-12-12 |
| The Effect of Lixisenatide on the Effect of Pituitary Hormones Placebo, Lixisenatide 10 micrograms (50 micrograms/ml in 3 ml) Pen Injector - Healthy, Type 1 Diabetes | Phase 4 | Unknown | University of Tartu | 10 | 2023-04-17 | 2023-06-12 |
| Human Versus Analogue Insulin for Youth With Type 1 Diabetes in Low-Resource Settings Insulin Glargine, NPH or premixed 70/30 (human insulin) - Diabetes Mellitus, Type 1, Type 1 Diabetes | Phase 4 | Completed | Jing Luo | 400 | 2023-03-15 | 2025-09-10 |
| Cholesterol Lowering and Residual Risk in Diabetes, Type 1 Evolocumab Cartridge, Atorvastatin Calcium Tablets, Ezetimibe Tablets - Type 1 Diabetes | Phase 4 | Recruiting | NYU Langone Health | 125 | 2022-12-06 | 2026-10-28 |
| Impact of Introducing Basaglar Insulin to the Treatment Regimen of Youth With Diabetes in Pakistan biosimilar insulin glargine - Type 1 Diabetes | Phase 4 | Completed | Life for a Child Program, Diabetes Australia | 296 | 2022-06-09 | 2025-07-30 |
| Afrezza With Basal Combination (ABC): Afrezza® Combined With AID Pump or Insulin Degludec in Adults With Type 1 Diabetes Afrezza (insulin human) Inhalation Powder, insulin degludec, Continuous Subcutaneous Insulin Infusion (CSII) pump with Automatic Insulin Delivery (AID) - Type 1 Diabetes | Phase 4 | Completed | Mannkind Corporation | 33 | 2022-03-31 | 2025-04-08 |
| Dual-Hormone Closed-Loop Glucose Control in Adolescents With Type 1 Diabetes Glucagon, Closed-loop System - Type 1 Diabetes | Phase 4 | Completed | Steno Diabetes Center Copenhagen | 11 | 2021-05-20 | 2022-08-18 |
| A Study to Evaluate Pneumococcal Polysaccharide Vaccine Effectiveness in Children With Type 1 Diabetes Pneumovax 23- pneumococcal polysaccharide, Blood draw - Type 1 Diabetes | Phase 4 | Completed | Mayo Clinic | 29 | 2021-04-30 | 2023-11-08 |
| Intravenous Insulin vs Subcutaneous Insulin Infusion in Intrapartum Management of Type 1 Diabetes Mellitus Insulin - Type 1 Diabetes, Pregnancy, High Risk | Phase 4 | Completed | Gianna Wilkie | 70 | 2021-03-15 | 2024-07-08 |
| Fast-Acting Insulin Aspart and Insulin Pump Settings Insulin aspart, Fast-acting insulin aspart - Type 1 Diabetes | Phase 4 | Unknown | Kirsten Nørgaard | 40 | 2021-02-01 | 2021-02-16 |
| Early Basal Insulin Administration in Adult Diabetic Ketoacidosis Management Early Glargine, Late Glargine, IV insulin infusion - Diabetic Ketoacidosis, Type 1 Diabetes | Phase 4 | Terminated | The Cleveland Clinic | 39 | 2020-10-01 | 2022-09-21 |
| Comparison of Glargine to Degludec Insulin Transition With or Without a Bridging Glargine Dose Insulin Degludec, Insulin Glargine, Placebo - Type 1 Diabetes | Phase 4 | Completed | University of Washington | 59 | 2020-02-14 | 2024-02-28 |
| Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes Forxiga - Nephropathy, Hypoxia | Phase 4 | Completed | Steno Diabetes Center Copenhagen | 30 | 2020-02-01 | 2021-02-03 |
| Insulin Pump to Multiple Daily Injection Transition Clinical Trial Multiple daily ijnection using Insulin Degludec and Insulin Aspart - Type 1 Diabetes | Phase 4 | Completed | University of Colorado, Denver | 38 | 2020-01-10 | 2021-09-13 |
| A Study of Rapid-Acting Mealtime Insulin in Children and Adolescents With Newly Diagnosed Type 1 Diabetes Mellitus Rapid-Acting Insulin, Long acting insulin - Diabetes Mellitus, Type 1 Diabetes | Phase 4 | Completed | Emory University | 24 | 2019-11-27 | 2021-09-30 |
| Dual-hormone Closed-loop Glucose Control in Type 1 Diabetes Glucagon, Closed-loop system - Type 1 Diabetes, Hypoglycemia | Phase 4 | Completed | Steno Diabetes Center Copenhagen | 13 | 2019-07-16 | 2022-08-18 |
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Diabetes Mellitus, Type 1 (53) · Diabetes Mellitus (12) · Hypoglycemia (6) · Insulin Resistance (6) · Diabetes Mellitus, Type 2 (3) · Diabetic Nephropathies (3) · Albuminuria (1) · Autoimmune Diseases (1) · Diabetic Ketoacidosis (1) · Diabetic Neuropathies (1) · Hyperglycemia (1) · Hypoxia (1) · Ketosis (1) · Kidney Diseases (1) · Lipodystrophy (1)
Endocrine System Diseases (53) · Glucose Metabolism Disorders (53) · Immune System Diseases (53) · Metabolic Diseases (53) · Nutritional and Metabolic Diseases (53) · Autoimmune Diseases (52) · Diabetes Mellitus (41) · Hyperinsulinism (6) · Diabetes Complications (5) · Female Urogenital Diseases (4) · Female Urogenital Diseases and Pregnancy Complications (4) · Male Urogenital Diseases (4) · Pathological Conditions, Signs and Symptoms (4) · Signs and Symptoms (4) · Urogenital Diseases (4)
Insulin Glargine (10) · Insulin (9) · Insulin Aspart (9) · Insulin Lispro (6) · Exenatide (3) · Sitagliptin Phosphate (3) · dapagliflozin (3) · pramlintide (3) · Blood Specimen Collection (2) · Dipeptidyl-Peptidase IV Inhibitors (2) · Glucagon (2) · Insulin Detemir (2) · Insulin, Long-Acting (2) · Isophane Insulin, Human (2) · Metformin (2)
University of Colorado, Denver (5) · Baylor College of Medicine (4) · Steno Diabetes Center Copenhagen (3) · Albert Einstein College of Medicine (2) · Emory University (2) · Mayo Clinic (2) · CHU de Quebec-Universite Laval (1) · Command Hospital, India (1) · Dasman Diabetes Institute (1) · Gianna Wilkie (1) · Hvidovre University Hospital (1) · Jing Luo (1) · Kinderkrankenhaus auf der Bult (1) · Kirsten Nørgaard (1) · Life for a Child Program, Diabetes Australia (1)
United States (24) · Denmark (7) · Canada (3) · China (3) · Pakistan (2) · United Kingdom (2) · Australia (1) · Austria (1) · Bangladesh (1) · Burkina Faso (1) · Estonia (1) · France (1) · India (1) · Israel (1) · Kuwait (1)
Rubina A Heptulla, MD (2) · Rubina Heptulla, MD (2) · Tao Yang, MD/PhD (2) · Agnieszka Szypowska (1) · Ajenthen G Ranjan, MD, PhD (1) · Ana Creo, MD (1) · Anna Brewton, MD (1) · Arthi Thirumalai, MD (1) · Carlson Karen, MD (1) · Cheril Clarson, MD (1) · Eric I Felner, MD (1) · Fahd Al-Mulla, MD, PhD (1) · Gianna L Wilkie, MD (1) · Ira Goldberg, MD (1)
PMID 15505016, PMID 15616226, PMID 15793249, PMID 18299307, PMID 18847622, PMID 19190104, PMID 21923696, PMID 22727048, PMID 23186950, PMID 23490599, PMID 24106787, PMID 24794703, PMID 26015558, PMID 26033508, PMID 26277548, PMID 27068361, PMID 27075708, PMID 27326862, PMID 27797928, PMID 28555339, PMID 28722271, PMID 31010873, PMID 32738019, PMID 34386735, PMID 36617389, PMID 36879107, PMID 37429432, PMID 38418413, PMID 39667114, PMID 39735417, PMID 39890140, PMID 40531276, PMID 41771842, PMID 42409045
2019 (2), R01DK077166 (2), 2014 (1), 2015 (1)