8 completed. 8 Phase 2, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Completed 8 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Tuberculosis, Central Nervous System: new trials by email Literature Review of Tuberculosis, Central Nervous System trials Research Report on Tuberculosis, Central Nervous System
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacokinetic Study of Linezolid for TB Meningitis Linezolid - Tuberculosis, Meningeal, Linezolid | Phase 2 | Completed | Universitas Padjadjaran | 36 | 2021-06-21 | 2023-09-06 |
| Adjunctive Linezolid for the Treatment of Tuberculous Meningitis LZD, High dose RIF, Standard dose RIF - Tuberculosis, Meningeal | Phase 2 | Completed | University of California, San Francisco | 40 | 2021-05-05 | 2024-10-01 |
| Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM Linezolid, High dose rifampicin, Aspirin - Tuberculosis Meningitis, HIV-1-infection | Phase 2 | Completed | University of Cape Town | 52 | 2019-06-12 | 2021-09-28 |
| Optimizing Treatment to Improve TBM Outcomes in Children High-dose: RIF, INH, PZA, EMB, High dose: RIF, INH, PZA, LEVO, Standard of care: RIF, INH, PZA, EMB - Tuberculosis, Meningeal | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 38 | 2017-02-22 | 2021-10-28 |
| High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Placebo, Rifampicin, Other TB drugs - Tuberculosis, Meningeal | Phase 2 / Phase 3 | Completed | Universitas Padjadjaran | 60 | 2014-12-01 | 2017-06-01 |
| A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis 81mg aspirin, 1000mg aspirin, Placebo - Tuberculous Meningitis | Phase 2 | Completed | Oxford University Clinical Research Unit, Vietnam | 120 | 2014-10-17 | 2017-03-07 |
| Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation Rifampicin intravenous, Oral rifampicin - Tuberculous Meningitis | Phase 2 | Completed | Universitas Padjadjaran | 30 | 2013-06-01 | 2014-06-17 |
| Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study Moxifloxacin - Meningitis, Tuberculous, Pharmacokinetics | Phase 2 | Completed | Universitas Padjadjaran | 60 | 2010-10-01 | 2012-06-07 |
Actinomycetales Infections (8) · Bacterial Infections (8) · Bacterial Infections and Mycoses (8) · Central Nervous System Bacterial Infections (8) · Central Nervous System Diseases (8) · Central Nervous System Infections (8) · Gram-Positive Bacterial Infections (8) · Infections (8) · Meningitis (8) · Meningitis, Bacterial (8) · Mycobacterium Infections (8) · Nervous System Diseases (8) · Neuroinflammatory Diseases (8) · Tuberculosis (8)
Rifampin (5) · Linezolid (3) · Aspirin (2) · Control Groups (1) · Dexamethasone (1) · Isoniazid (1) · Levofloxacin (1) · Moxifloxacin (1) · NSC 366140 (1)
Universitas Padjadjaran (4) · Johns Hopkins University (1) · Oxford University Clinical Research Unit, Vietnam (1) · University of California, San Francisco (1) · University of Cape Town (1)
Indonesia (4) · India (1) · Malawi (1) · South Africa (1) · Uganda (1) · Vietnam (1)
Rovina Ruslami, M.D., PhD (2) · Ahmad R Ganiem, MD, PhD (1) · Angharad G Davis, Dr (1) · Felicia C Chow, MD (1) · Graeme Meintjes, PhD (1) · Guy Thwaites, MD, PhD (1) · John Black, MBChB (1) · Kelly Dooley, MD,PhD (1) · Nguyen H Phu, MD, PhD (1) · Robert J Wilkinson, PhD (1) · Rovina Ruslami, PhD (1) · Sean Wasserman, MMed (1)
PMID 23103177, PMID 25703312, PMID 29482717, PMID 30224533, PMID 33972248, PMID 34286103, PMID 35291004, PMID 36482216, PMID 37740554
R01HD074944 (1), R21TW011035 (1)