8 completed, 1 terminated, 1 withdrawn. 9 Phase 2, 3 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 9 | Completed 8, Withdrawn 1 |
| Phase 1 | 3 | Completed 2, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow NSC 366140: new trials by email Literature Review of NSC 366140 trials Research Report on NSC 366140
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing Treatment to Improve TBM Outcomes in Children High-dose: RIF, INH, PZA, EMB, High dose: RIF, INH, PZA, LEVO, Standard of care: RIF, INH, PZA, EMB - Tuberculosis, Meningeal | Phase 1 / Phase 2 | Completed | Johns Hopkins University | 38 | 2017-02-22 | 2021-10-28 |
| Efficacy of HUEXC030 in Subjects With Pulmonary Tuberculosis Isoniazid with HUEXC030 and RZE, HRZE - Pulmonary Tuberculosis | Phase 2 / Phase 3 | Completed | Orient Pharma Co., Ltd. | 557 | 2012-12-06 | 2022-06-15 |
| Pyrazoloacridine and Stem Cell or Bone Marrow Transplantation in Treating Young Patients With High-Risk Neuroblastoma pyrazoloacridine, filgrastim, autologous bone marrow transplantation - Disseminated Neuroblastoma, Recurrent Neuroblastoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 42 | 2002-12-01 | 2013-04-09 |
| Pyrazoloacridine Followed by Radiation Therapy in Treating Adults With Newly Diagnosed Supratentorial Glioblastoma Multiforme pyrazoloacridine, adjuvant therapy, radiation therapy - Brain and Central Nervous System Tumors | Phase 1 / Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 2000-05-01 | 2012-05-03 | |
| Pyrazoloacridine Plus Carboplatin in Treating Patients With Recurrent Glioma carboplatin, pyrazoloacridine - Brain and Central Nervous System Tumors | Phase 2 | Completed | National Cancer Institute (NCI) | 60 | 2000-05-01 | 2013-06-03 |
| Pyrazoloacridine in Treating Patients With Metastatic Skin or Eye Melanoma pyrazoloacridine - Intraocular Melanoma, Melanoma (Skin) | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 1999-02-01 | 2012-12-17 | |
| Pyrazoloacridine in Treating Women With Refractory Metastatic Breast Cancer pyrazoloacridine - Breast Cancer | Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 1997-07-01 | 2013-01-31 | |
| Pyrazoloacridine in Treating Patients With Advanced Non-small Cell Lung Cancer pyrazoloacridine - Lung Cancer | Phase 2 | Completed | Barbara Ann Karmanos Cancer Institute | 20 | 1995-10-01 | 2013-04-29 |
| Pyrazoloacridine in Treating Women With Metastatic Breast Cancer pyrazoloacridine - Breast Cancer | Phase 2 | Completed | Barbara Ann Karmanos Cancer Institute | 20 | 1994-02-01 | 2012-03-12 |
| Chemotherapy in Treating Patients With Unresectable Primary or Metastatic Kidney Cancer Pyrazoloacridine - Liver Cancer, Metastatic Cancer | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2012-02-22 |
Breast Neoplasms (2) · Central Nervous System Neoplasms (2) · Glioblastoma (2) · Gliosarcoma (2) · Astrocytoma (1) · Brain Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1) · Glioma (1) · Liver Neoplasms (1) · Lung Neoplasms (1) · Melanoma (1) · Neoplasm Metastasis (1) · Neuroblastoma (1) · Oligodendroglioma (1)
Barbara Ann Karmanos Cancer Institute (2) · National Cancer Institute (NCI) (2) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2) · Johns Hopkins University (1) · M.D. Anderson Cancer Center (1) · Ohio State University Comprehensive Cancer Center (1) · Orient Pharma Co., Ltd. (1)
United States (7) · Canada (1) · India (1) · Malawi (1) · Taiwan (1)
Anna Butturini (1) · Antoinette J. Wozniak, MD (1) · Eric H. Kraut, MD (1) · Evanthia Galanis, MD (1) · Glenn J. Lesser, MD (1) · Kelly Dooley, MD,PhD (1) · Patricia M. LoRusso, DO (1) · William H. Sharfman, MD (1) · Yehuda Z. Patt, MD (1) · Yu-Pu Hu, PhD (1)
P30CA006973 (2), P30CA022453 (2), P01CA081403 (1), P30CA016672 (1), R01HD074944 (1), U01CA062475 (1), U01CA063437 (1), U01CA070172 (1)