6 completed, 2 recruiting, 2 terminated. 3 Phase 2, 2 Not applicable, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 2, Recruiting 1 |
| Not applicable | 2 | Completed 1, Terminated 1 |
| Phase 1 | 2 | Completed 2 |
Follow Tricuspid Atresia: new trials by email Literature Review of Tricuspid Atresia trials Research Report on Tricuspid Atresia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts Tissue Engineered Vascular Grafts - HLH - Hypoplastic Left Heart Syndrome, DORV | Phase 2 | Recruiting | Nationwide Children's Hospital | 24 | 2020-07-15 | 2025-06-27 |
| NIRS in Congenital Heart Defects - Correlation With Echocardiography NIRS evaluation - Congenital Heart Defect, Single-ventricle | Recruiting | McGill University Health Centre/Research Institute of the McGill University Health Centre | 100 | 2019-10-11 | 2025-06-17 | |
| Methacetin Breath Test in Patients With Liver Disease Secondary to Heart Disease Methacetin Breath Test (MBT) - Dilated Cardiomyopathy, Tricuspid Atresia | Not applicable | Terminated | Northwestern University | 4 | 2019-04-21 | 2023-04-05 |
| Study of Placebo or Bosentan to Treat Patients With Single Ventricle Physiology. Bosentan, Placebo - Hypoplastic Left Heart Syndrome, Tricuspid Atresia | Phase 2 | Completed | Copenhagen University Hospital, Rigshospitalet | 75 | 2011-02-01 | 2013-04-19 |
| Global and Regional Myocardial Strain and Power Output In Patients With Single Ventricles Using Novel MRI Techniques Fontan Procedure, Hypoplastic Left Heart Syndrome | Terminated | University of California, San Francisco | 13 | 2009-11-01 | 2020-01-21 | |
| Impact of Vitamin C on Endothelial Function and Exercise Capacity in Fontan-Palliated Patients Vitamin C, Placebo - Fontan Procedure, Hypoplastic Left Heart Syndrome | Not applicable | Completed | University of Michigan | 53 | 2009-06-01 | 2017-06-01 |
| Sildenafil After the Fontan Operation Sildenafil, Placebo - Hypoplastic Left Heart Syndrome, Tricuspid Atresia | Phase 2 | Completed | Children's Hospital of Philadelphia | 28 | 2007-12-01 | 2015-05-05 |
| Biomarker Study for Heart Failure in Children With Single Ventricle Physiology Tricuspid Atresia, Hypoplastic Left Heart Syndrome | Completed | University of California, San Francisco | 71 | 2007-02-01 | 2015-05-14 | |
| Understanding Dexmedetomidine In Infants Post-Operative From Cardiac Surgery Dexmedetomidine - Hypoplastic Left Heart, Tetralogy of Fallot | Phase 1 | Completed | Athena Zuppa | 56 | 2004-05-01 | 2013-04-09 |
| Liothyronine in Children With Single Ventricle Congenital Cardiac Malformations Undergoing the Fontan Procedure liothyronine I 131 - Tricuspid Atresia, Heart Defects, Congenital | Phase 1 | Completed | FDA Office of Orphan Products Development | 28 | 1994-12-01 | 2015-03-25 |
Hypoplastic Left Heart Syndrome (8) · Heart Defects, Congenital (4) · Univentricular Heart (3) · Tetralogy of Fallot (2) · Aortic Coarctation (1) · Cardiomyopathy, Dilated (1) · Cardiovascular Abnormalities (1) · Cardiovascular Diseases (1) · Endocardial Cushion Defects (1) · Heart Diseases (1) · Heart Failure (1) · Pulmonary Atresia (1) · Rare Diseases (1) · Respiratory Tract Diseases (1)
Congenital Abnormalities (10) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Heart Valve Diseases (10) · Cardiovascular Abnormalities (9) · Cardiovascular Diseases (9) · Heart Diseases (9) · Heart Defects, Congenital (6) · Cardiomegaly (1) · Cardiomyopathies (1) · Disease Attributes (1) · Genetic Diseases, Inborn (1) · Heart Septal Defects (1) · Laminopathies (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1)
Ascorbic Acid (1) · Blood Vessel Prosthesis (1) · Bosentan (1) · Dexmedetomidine (1) · Sildenafil Citrate (1)
University of California, San Francisco (2) · Athena Zuppa (1) · Children's Hospital of Philadelphia (1) · Copenhagen University Hospital, Rigshospitalet (1) · FDA Office of Orphan Products Development (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · Nationwide Children's Hospital (1) · Northwestern University (1) · University of Michigan (1)
United States (5) · Canada (1) · Denmark (1) · Sweden (1)
Alexander Lowenthal, MD (1) · Alison Meadows, MD, PhD (1) · Anders H Hebert, MD (1) · Athena Zuppa, MD, MSCE (1) · Bryan H Goldstein, MD (1) · Christopher Breuer, MD (1) · Daniel R Ganger, MD (1) · Gabriel Altit (1) · Harold Bernstein, MD, PhD (1) · Jack Rychik, MD (1) · John R Charpie, MD (1) · Lars Sondergaard, DMSc (1) · Mark Galantowicz, MD (1) · Richard Mainwaring (1) · Toshiharu Shinoka, MD/PhD (1)
PMID 19840577, PMID 21081737, PMID 21382896, PMID 21600541, PMID 22176653, PMID 22196786, PMID 23663658, PMID 25446057, PMID 34253175
5UH3HL148693 (1)