58 completed, 6 terminated, 4 recruiting, 2 active not recruiting. 32 Phase 2, 19 Phase 1, 16 Phase 3, 15 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety of MT-401-OTS in Patients With Relapsed AML or MDS MT-401-OTS - Acute Myeloid Leukemia, in Relapse, MDS | Phase 1 | Recruiting | Marker Therapeutics, Inc. | 40 | 2025-06-16 | 2025-12-16 |
| Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System Cardiohelp device (VA-ECMO), Heparin, Bivalirudin - Heart Failure, Cardiogenic Shock | Phase 2 | Recruiting | Stanford University | 50 | 2025-04-15 | 2026-08-10 |
| Interferon-γ (IFN-γ) With Donor Leukocyte Infusion to Treat Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndromes Post Allogeneic Hematopoietic Stem Cell Transplantation Interferon gamma-1b, Donor Leukocyte Infusion (DLI) - Acute Myeloid Leukemia, Myelodysplastic Syndromes | Phase 2 | Recruiting | Sawa Ito, MD | 57 | 2024-09-23 | 2026-08-11 |
| SELVA: A Phase 3 Study Evaluating QTORIN 3.9% Rapamycin Anhydrous Gel in the Treatment of Microcystic Lymphatic Malformations QTORIN 3.9% Rapamycin Anhydrous Gel - Microcystic Lymphatic Malformation | Phase 3 | Active not recruiting | Palvella Therapeutics, Inc. | 51 | 2024-07-31 | 2026-03-27 |
| Danvatirsen Monotherapy Followed by Combination With Venetoclax in Relapsed/Refractory MDS & AML Danvatirsen, Danvatirsen + Venetoclax - AML/MDS, Acute Myeloid Leukemia | Phase 1 | Recruiting | Montefiore Medical Center | 38 | 2024-05-08 | 2026-10-15 |
| Daily Vitamin D for Sickle-cell Respiratory Complications Daily oral vitamin D3, 3,333 IU, Monthly oral vitamin D3, 100,000 IU, Placebo oral tablet - Sickle Cell Disease, Anemia, Sickle Cell | Phase 2 | Completed | Columbia University | 58 | 2020-09-15 | 2025-09-24 |
| KPT-330 Plus RICE for Relapsed/Refractory Aggressive B-Cell Lymphoma KPT-330, Rituximab, Etoposide - Diffuse Large B-Cell Lymphoma | Phase 1 | Completed | Weill Medical College of Cornell University | 22 | 2015-12-11 | 2022-04-12 |
| Abatacept as GVHD Prophylaxis Phase 2 Abatacept, placebo - Graft vs Host Disease, Malignancy | Phase 2 | Completed | Boston Children's Hospital | 186 | 2013-02-01 | 2025-12-11 |
| Efficacy and Safety Study of Nexagon for Persistent Corneal Epithelial Defects Nexagon, Vehicle only - Persistent Corneal Epithelial Defects | Phase 2 | Terminated | University of California, San Francisco | 2 | 2011-11-01 | 2015-05-07 |
| ABC294640 in Treating Patients With Advanced Solid Tumors sphingosine kinase-2 inhibitor ABC294640 - Pancreatic Cancer, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | Completed | RedHill Biopharma Limited | 22 | 2011-08-01 | 2020-01-07 |
| Efficacy Study of NH001 in Vegetative State & Minimally Conscious State Following a Traumatic Brain Injury Apomorphine, Placebo - Brain Injury | Phase 2 | Suspended | NeuroHealing Pharmaceuticals Inc. | 76 | 2010-07-01 | 2017-03-31 |
| Alendronate in Juvenile Osteoporosis Alendronate (Fosamax) - Juvenile Osteoporosis, Low Bone Density | Completed | Medical University of South Carolina | 11 | 2009-07-01 | 2018-07-11 | |
| Study of Repeat Intranodal Injection of Memgen's Cancer Vaccine, Ad-ISF35, in Subjects With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) ISF35 - Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | Phase 2 | Terminated | Januario Castro, M.D. | 6 | 2009-01-01 | 2015-12-30 |
| Radioimmunoimaging of AL Amyloidosis 124I-labeled monoclonal antibody Mu 11-1F4 - Primary Amyloidosis | Phase 1 | Completed | University of Tennessee | 40 | 2008-12-01 | 2013-09-18 |
| MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID ADA gene transfer - Severe Combined Immunodeficiency | Phase 2 | Completed | Donald B. Kohn, M.D. | 10 | 2008-11-01 | 2021-04-23 |
| 8-Chloro-Adenosine in Chronic Lymphocytic Leukemia 8-Chloro-Adenosine - Leukemia, Chronic Lymphocytic Leukemia | Phase 1 | Completed | M.D. Anderson Cancer Center | 11 | 2008-06-01 | 2016-10-13 |
| A Safety and Efficacy Study of AEGR-733 to Treat Homozygous Familial Hypercholesterolemia (FH) AEGR-733 - Homozygous Familial Hypercholesterolemia | Phase 3 | Completed | Aegerion Pharmaceuticals, Inc. | 29 | 2007-12-01 | 2018-03-20 |
| Clinical Trial of Vincristine vs. Prednisolone for Treatment of Complicated Hemangiomas Vincristine, Prednisone - Hemangioma | Phase 2 | Terminated | Medical College of Wisconsin | 8 | 2007-11-01 | 2013-06-11 |
| Penicillamine Chelation for Children With Lead Poisoning d-penicillamine, placebo - Lead Poisoning, Vitamin D Deficiency | Phase 2 / Phase 3 | Withdrawn | FDA Office of Orphan Products Development | 2007-09-01 | 2015-03-26 | |
| Safety and PK of Nikkomycin Z for Coccidioides Pneumonia Treatment nikkomycin Z, Placebo - Coccidioidomycosis | Phase 1 / Phase 2 | Terminated | University of Arizona | 6 | 2007-09-01 | 2025-04-16 |
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Rare Diseases (21) · Respiratory Tract Diseases (9) · Genetic Diseases, Inborn (6) · Cystic Fibrosis (5) · Anemia, Sickle Cell (4) · Communicable Diseases (3) · Immune System Diseases (3) · Leukemia, Myeloid, Acute (3) · Urogenital Diseases (3) · Amyloidosis (2) · Bacterial Infections (2) · Fractures, Bone (2) · Gastrointestinal Diseases (2) · Graft vs Host Disease (2) · Heart Defects, Congenital (2)
ADI PEG20 (2) · Alendronate (2) · Cholecalciferol (2) · Dexamethasone (2) · Etanercept (2) · Minocycline (2) · Oxandrolone (2) · Prednisone (2) · Solutions (2) · Thalidomide (2) · 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide (1) · 4-Aminopyridine (1) · 8-chloroadenosine (1) · Abatacept (1) · Administration, Oral (1)
United States (51) · Canada (8) · Finland (2) · France (2) · Italy (2) · United Kingdom (2) · Belgium (1) · Germany (1) · Israel (1) · Japan (1) · Lithuania (1) · Netherlands (1) · Poland (1) · Russia (1) · South Africa (1)
Deborah A Bowlby, M.D. (2) · Abhimanyu Garg, M.D. (1) · Aditi Shastri, MBBS (1) · Alan Bruce Montgomery (1) · Alan Solomon, MD (1) · Annette S. Feigenbaum, MD (1) · Bennie H Jeng, MD (1) · Beth Drolet, MD (1) · Caroline Ozment, MD (1) · Carolyn Britten, MD (1) · Carolyn C Hoppe, M.D. (1) · Daniel F Hanley, MD (1) · David E Nix, Pharm D (1) · Debra Weiner, MD, PhD (1)
PMID 12795371, PMID 11588741, PMID 12905485, PMID 15751091, PMID 15838068, PMID 15986348, PMID 16378799, PMID 16646004, PMID 17554116, PMID 18406958, PMID 20522711, PMID 21180274, PMID 21410393, PMID 21477202, PMID 21940973, PMID 22127969, PMID 22382155, PMID 22474059, PMID 23370203, PMID 23447519, PMID 23463422, PMID 23622922, PMID 24159565, PMID 25405392, PMID 25897792, PMID 25979023, PMID 26228884, PMID 26723464, PMID 26799509, PMID 26825712, PMID 28346229, PMID 29948025, PMID 30846465, PMID 33331662, PMID 33974038, PMID 35914227, PMID 36520008, PMID 36927115, PMID 37319437, PMID 37811711, PMID 37983082, PMID 38583802, PMID 38775255, PMID 9628377
R01FD001847 (1), U01HL068270 (1), U54RR019498 (1)