2 completed. 2 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 2 | Completed 2 |
Follow Treatment-Refractory Depression: new trials by email Literature Review of Treatment-Refractory Depression trials Research Report on Treatment-Refractory Depression
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT) Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion - Depression, Dementia | Phase 4 | Completed | Centre for Addiction and Mental Health | 87 | 2019-08-01 | 2024-11-25 |
| Optimizing Outcomes of Treatment-Resistant Depression in Older Adults Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion - Treatment Resistant Depression, Major Depressive Disorder | Phase 4 | Completed | Washington University School of Medicine | 742 | 2017-02-24 | 2024-10-03 |
Depressive Disorder, Major (2) · Depressive Disorder, Treatment-Resistant (2) · Cognitive Dysfunction (1) · Dementia (1) · Depression (1)
Depressive Disorder (2) · Mental Disorders (2) · Mood Disorders (2) · Behavior (1) · Behavioral Symptoms (1) · Brain Diseases (1) · Central Nervous System Diseases (1) · Cognition Disorders (1) · Nervous System Diseases (1) · Neurocognitive Disorders (1)
Aripiprazole (2) · Bupropion (2) · Lithium Carbonate (2) · Nortriptyline (2)
Centre for Addiction and Mental Health (1) · Washington University School of Medicine (1)
Canada (2) · United States (2)
Aristotle Voineskos, MD (1) · Eric Lenze, MD (1)
PMID 36867173, PMID 38822571, PMID 41237789
R01MH114966 (1), R01MH114970 (1), R01MH114980 (1), R01MH114981 (1)