9 completed, 3 recruiting, 3 unknown, 2 terminated. 18 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 18 | Completed 9, Recruiting 3, Unknown 3, Terminated 2, Withdrawn 1 |
Follow Toxemia: new trials by email Literature Review of Toxemia trials Research Report on Toxemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Progesterone Preeclampsia Progesterone supplementation - Preeclampsia, Hypertensive Disorder of Pregnancy | Phase 4 | Recruiting | Medical University of South Carolina | 642 | 2026-08-13 | 2026-08-17 |
| Immunomodulatory Effects of Dexamethasone, Tocilizumab and Anakinra During Experimental Human Endotoxemia Dexamethasone, Tocilizumab, Anakinra - Sepsis, Neuroinflammatory Response | Phase 4 | Unknown | Radboud University Medical Center | 52 | 2024-10-24 | 2025-04-04 |
| Treatment With Aspirin After Preeclampsia: TAP Trial Low-dose aspirin, Placebo - Hypertensive Disorder of Pregnancy, Pre-Eclampsia | Phase 4 | Recruiting | Malamo Countouris | 60 | 2024-05-29 | 2026-09-22 |
| Optimal Blood Pressure Treatment Thresholds Postpartum Usual care, Tight blood pressure control - Hypertensive Disorder of Pregnancy, Pre-Eclampsia | Phase 4 | Completed | Alisse Hauspurg | 61 | 2023-11-15 | 2026-06-02 |
| LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention Aspirin, Tinzaparin - Preeclampsia Severe, Toxemia Of Pregnancy | Phase 4 | Recruiting | Alexandra Hospital, Athens, Greece | 100 | 2023-01-18 | 2026-01-23 |
| Rifaximin in Cirrhosis: Effects on Endotoxin and Haemostatic Indexes Rifaximin, Placebo - Liver Cirrhosis, Coagulation Disorder | Phase 4 | Terminated | University of Roma La Sapienza | 20 | 2021-04-03 | 2024-10-08 |
| Therapeutic Drug Monitoring and Continuous Infusion of Beta-lactam Antibiotics in Patients With Bacteraemia Continuous infusion of beta-lactam antibiotics ., Therapeutic drug monitoring of beta-lactam antibiotics. - Bacteremia | Phase 4 | Withdrawn | Sara Thønnings | 2017-10-01 | 2023-03-29 | |
| Defibrotide in the Human Endotoxemia Model --- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide Defibrotide, Placebo (0.9% sodium chloride), Lipopolysaccharide - Healthy Volunteers, Endotoxemia | Phase 4 | Completed | Bernd Jilma | 20 | 2017-04-18 | 2019-12-19 |
| An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures Amoxicillin, Amoxicillin-Potassium Clavulanate - Bacteraemia, Endocarditis | Phase 4 | Terminated | University of Santiago de Compostela | 40 | 2017-02-27 | 2022-05-24 |
| Efficacy and Safety of Rheosorbilact® Solution for Infusion, in a Complex Therapy of Sepsis. Rheosorbilact®, Ringer lactate - Sepsis, Intoxication; Septic | Phase 4 | Completed | Yuria-Pharm | 180 | 2016-12-06 | 2020-02-21 |
| A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Vitamin D3 - Gestational Hypertension, Toxemia | Phase 4 | Unknown | Stony Brook University | 412 | 2016-10-01 | 2017-10-05 |
| Efficacy of Umbilical Cord Cleansing With a Single Application of 4% Chlorhexidine for the Prevention of Newborn Infections in Uganda: a Randomized Controlled Trial Intervention arm: 4% chlorhexidine - Omphalitis, Septicaemia | Phase 4 | Completed | Makerere University | 4760 | 2016-07-01 | 2025-04-06 |
| Vorapaxar in the Human Endotoxemia Model Vorapaxar, Placebo, LPS - Healthy Volunteers | Phase 4 | Completed | Medical University of Vienna | 16 | 2016-06-01 | 2020-01-10 |
| Effects of Vasopressors on Immune Response Norepinephrine, Phenylephrine, Vasopressins - Endotoxemia | Phase 4 | Completed | Radboud University Medical Center | 40 | 2016-01-01 | 2016-10-13 |
| Rifaximin Predicts the Complications of Decompensated Cirrhosis rifaximin - Cirrhosis | Phase 4 | Unknown | Shanghai Changzheng Hospital | 250 | 2013-10-01 | 2014-02-28 |
| Understanding the Immune Response to Two Different Meningitis Vaccines MenACWY-CRM conjugate vaccine (Menveo, Novartis), MenACWY-PS polysaccharide vaccine, ( ACWYVax, GSK) and MenACWY-CRM conjugate vaccine (Menveo, Novartis), 1/5th dose MenACWY-PS polysaccharide vaccine, ( ACWYVax, GSK) and MenACWY-CRM conjugate vaccine (Menveo, Novartis) - Meningitis, Meningococcal Disease | Phase 4 | Completed | University of Oxford | 20 | 2012-12-01 | 2026-05-04 |
| Modulation of Systemic Inflammatory Response in Critically Ill Children After Glutamine Supplementation solution of amino acids supplemented with glutamine, amino acids not supplemented with glutamine - Inflammatory Response, Multi-organ Failure | Phase 4 | Completed | Hospital Sant Joan de Deu | 101 | 2010-04-01 | 2013-09-06 |
| The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia Dipyridamole, Placebo, LPS - Endotoxemia | Phase 4 | Completed | Radboud University Medical Center | 30 | 2010-03-01 | 2010-11-05 |
Endotoxemia (7) · Hypertension, Pregnancy-Induced (4) · Pre-Eclampsia (4) · Eclampsia (3) · Pregnancy Complications (3) · Cardiovascular Diseases (2) · Hypertension (2) · Inflammation (2) · Sepsis (2) · Vascular Diseases (2) · Bacteremia (1) · Blood Platelet Disorders (1) · Diabetes Insipidus (1) · Endocarditis (1)
Infections (18) · Pathologic Processes (10) · Pathological Conditions, Signs and Symptoms (10) · Systemic Inflammatory Response Syndrome (9) · Bacteremia (7) · Inflammation (7) · Sepsis (7) · Female Urogenital Diseases and Pregnancy Complications (6) · Urogenital Diseases (6) · Cardiovascular Diseases (5) · Vascular Diseases (4) · Bacterial Infections (2) · Bacterial Infections and Mycoses (2) · Hypertension (2)
Lipopolysaccharides (3) · Aspirin (2) · Rifaximin (2) · Sodium Chloride (2) · Amoxicillin (1) · Amoxicillin-Potassium Clavulanate Combination (1) · Ampicillin (1) · Arginine Vasopressin (1) · Cefuroxime (1) · Chlorhexidine (1) · Cholecalciferol (1) · Dexamethasone (1) · Dicloxacillin (1) · Dipyridamole (1) · Drugs, Generic (1)
Radboud University Medical Center (3) · Alexandra Hospital, Athens, Greece (1) · Alisse Hauspurg (1) · Bernd Jilma (1) · Hospital Sant Joan de Deu (1) · Makerere University (1) · Malamo Countouris (1) · Medical University of South Carolina (1) · Medical University of Vienna (1) · Sara Thønnings (1) · Shanghai Changzheng Hospital (1) · Stony Brook University (1) · University of Oxford (1) · University of Roma La Sapienza (1) · University of Santiago de Compostela (1)
United States (4) · Netherlands (3) · Austria (2) · Spain (2) · China (1) · Georgia (1) · Greece (1) · Italy (1) · Kazakhstan (1) · Moldova (1) · Uganda (1) · Ukraine (1) · United Kingdom (1) · Uzbekistan (1)
Alisse K Hauspurg, MD (2) · Bernd Jilma, MD (2) · Andrew J Pollard, BA, MBBS, FRCPCH, PhD (1) · Bart P Ramakers, MD (1) · Diana J Garretto, MD (1) · Georgios Daskalakis, PhD (1) · Iolanda Jordan, PhMD (1) · Lucia Stefanini, Prof. (1) · Manuela Merli, Prof. (1) · Oliviero Riggio, Prof. (1) · Pedro Diz, MD, DDS, PhD (1) · Roberto Carnevale, Prof. (1) · Roeland Stolk, MD (1)
PMID 16940094, PMID 18477269, PMID 20701619, PMID 22129171, PMID 23728678, PMID 27029851, PMID 28701228, PMID 31008870, PMID 33483132
2023 (1), K23HL168356 (1)