14 completed, 4 not yet recruiting, 2 recruiting, 2 unknown. 13 Not applicable, 3 Phase 4, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 8, Not yet recruiting 2, Unknown 2, Recruiting 1 |
| Phase 4 | 3 | Completed 2, Recruiting 1 |
| Phase 3 | 2 | Completed 1, Withdrawn 1 |
Follow Tonsillar Hypertrophy: new trials by email Literature Review of Tonsillar Hypertrophy trials Research Report on Tonsillar Hypertrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Full-wrap Versus Conventional Suspension for Reducing Soft Palate Injury Rate in Transoral Surgery Intraoperative soft palate suspension using the double-strap method., Intraoperative soft palate suspension using the full-wrap method. - Adenoid Hypertrophy, Tonsillar Hypertrophy | Not applicable | Not yet recruiting | Sun Yat-sen University | 138 | 2026-09-30 | 2026-07-10 |
| Evaluation of the Effects of Adenoidectomy and Adenotonsillectomy on Voice in Children Adenoid Hypertrophy, Tonsillar Hypertrophy | Not yet recruiting | Gaziosmanpasa Research and Education Hospital | 36 | 2026-02-01 | 2026-02-10 | |
| Self-assessment of Tonsil Size Tonsillar Hypertrophy | Not yet recruiting | Turku University Hospital | 90 | 2025-10-20 | 2025-10-03 | |
| Tonsillectomy vs. Tonsillotomy in Adults With Obstructive Sleep Apnea Tonsillectomy, Tonsillotomy - Obstructive Sleep Apnea, Tonsillar Hypertrophy | Not applicable | Not yet recruiting | University of Aarhus | 464 | 2025-01-01 | 2024-04-19 |
| Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia Methadone, Fentanyl/Hydromorphone - Pain, Postoperative, Tonsillar Hypertrophy | Phase 4 | Recruiting | Duke University | 440 | 2024-11-21 | 2025-12-05 |
| Safety and Efficacy of the Irreversible Electroporation (IRE) System for Adenotonsillar Hypertrophy in Children IRE System - Tonsillar Hypertrophy, Upper Airway Obstruction | Not applicable | Completed | ENTire Medical Ltd. | 31 | 2024-11-14 | 2026-07-08 |
| Evaluation of Eustachian Tube Function With 226 and 1000 Hz Probes in Children Undergoing Tonsillectomy ± Adenoidectomy Eustachian tube function test with 226 and 1000 Hz probes - Tonsillar Hypertrophy, Eustachian Tube Dysfunction | Completed | Sumeyra DOLUOGLU | 128 | 2024-08-20 | 2025-04-15 | |
| Metabolomic Profiling of Racial Disparity Blood collection - Adenoid Hypertrophy, Tonsillar Hypertrophy | Active not recruiting | Nationwide Children's Hospital | 84 | 2024-03-12 | 2025-10-27 | |
| Efficacy and Safety of Irreversible Electroporation for Chronic Symptomatic Tonsillar Hypertrophy Treatment IRE System - Tonsillar Hypertrophy | Not applicable | Completed | ENTire Medical Ltd. | 24 | 2024-01-17 | 2026-04-29 |
| Lateral Pharyngoplasty Outcomes in Children Undergoing Tonsillectomy Lateral pharyngoplasty, Tonsillectomy - Sleep-Disordered Breathing, Sleep Apnea Syndromes in Children | Not applicable | Recruiting | Loma Linda University | 160 | 2023-05-17 | 2026-02-23 |
| Intranasal Steroid as Medical Therapy For Sleep-Disordered Breathing in Children Mometasone Furoate 50mcg Nasal Spray, Sodium Chloride 0.9 % Nasal Spray - Sleep Disorder; Breathing-Related, Snoring | Phase 4 | Completed | Murdoch Childrens Research Institute | 130 | 2022-12-05 | 2025-09-30 |
| Opioid-sparing Effect of Intranasal Dexmedetomidine Dexmedetomidine - Tonsillar Hypertrophy | Not applicable | Completed | Pierre-Yves P Lequeux | 50 | 2022-02-25 | 2023-05-08 |
| Long-term Results of Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults Polysomnography - Obstructive Sleep Apnea, Tonsillar Hypertrophy | Not applicable | Completed | Turku University Hospital | 17 | 2022-01-25 | 2023-12-26 |
| Management of Post-Tonsillectomy Pain in Pediatric Patients Alternating Acetaminophen and Ibuprofen, Combined Acetaminophen and Ibuprofen - Pain, Postoperative, Tonsillar Hypertrophy | Phase 3 | Completed | Washington University School of Medicine | 50 | 2020-09-28 | 2024-07-11 |
| Intracapsular Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults Tonsillectomy - Tonsillar Hypertrophy, Sleep Apnea, Obstructive | Not applicable | Completed | Turku University Hospital | 25 | 2020-09-01 | 2025-04-25 |
| Evaluation of the Functional Impact of Adenotonsilectomy Adenotonsillectomy - Apnea, Obstructive, Tonsillitis | Completed | Instituto de Ciências Biomédicas Abel Salazar | 78 | 2020-08-20 | 2022-09-08 | |
| Tulobuterol Patch in Pediatric Patients Undergoing Tonsillectomy Tulobuterol Hydrochloride, Placebo transdermal patch - Tonsillar Hypertrophy | Not applicable | Completed | Seoul National University Hospital | 182 | 2019-12-20 | 2022-01-14 |
| Lidocaine Infusion for Pain Relief in Children Scheduled for Tonsillectomy and Adenoidectomy Lidocaine Iv, Saline Solution - Children, Only, Tonsillar Hypertrophy | Phase 4 | Completed | Rhode Island Hospital | 70 | 2019-05-07 | 2022-01-11 |
| Relationship of Endoplasmic Reticulum Stress and Tonsillar Tissue Diseases Tonsillectomy surgery - Tonsillitis, Tonsillar Hypertrophy | Completed | Selcuk University | 46 | 2018-11-01 | 2020-12-04 | |
| Interactive Perioperative Teaching Platform (IPTP) Interactive Perioperative Teaching Platform - Tonsillar Hypertrophy, Adenoid Hypertrophy | Not applicable | Completed | Vidya Raman | 151 | 2018-10-10 | 2021-02-03 |
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Sleep Apnea, Obstructive (7) · Tonsillitis (5) · Pain, Postoperative (4) · Sleep Apnea Syndromes (3) · Airway Obstruction (1) · Cryptorchidism (1) · Deception (1) · Dental Caries (1) · Hypospadias (1) · Immune System Diseases (1) · Infections (1) · Lung Diseases (1) · Nasopharyngeal Diseases (1) · Nasopharyngeal Neoplasms (1) · Otitis (1)
Respiratory Tract Diseases (12) · Nervous System Diseases (9) · Respiration Disorders (9) · Apnea (8) · Dyssomnias (8) · Pathological Conditions, Signs and Symptoms (8) · Sleep Disorders, Intrinsic (8) · Sleep Wake Disorders (8) · Otorhinolaryngologic Diseases (7) · Signs and Symptoms (7) · Stomatognathic Diseases (7) · Neurologic Manifestations (6) · Pharyngeal Diseases (6) · Respiratory Tract Infections (6) · Infections (5)
Tonsillectomy (4) · Acupuncture Therapy (1) · Blood Specimen Collection (1) · Dexmedetomidine (1) · Electrocoagulation (1) · Fentanyl (1) · Hydromorphone (1) · Ibuprofen (1) · Methadone (1) · Mometasone Furoate (1) · Nasal Sprays (1) · Polysomnography (1) · Saline Solution (1) · Sodium Chloride (1) · tulobuterol (1)
Turku University Hospital (3) · ENTire Medical Ltd. (2) · Gaziosmanpasa Research and Education Hospital (2) · Children's ENT of San Diego, Inc. (1) · Duke University (1) · Hadassah Medical Organization (1) · Instituto de Ciências Biomédicas Abel Salazar (1) · Loma Linda University (1) · Massachusetts Eye and Ear Infirmary (1) · Murdoch Childrens Research Institute (1) · Nationwide Children's Hospital (1) · Pierre-Yves P Lequeux (1) · Rhode Island Hospital (1) · Selcuk University (1) · Seoul National University Hospital (1)
United States (8) · Turkey (Türkiye) (4) · Finland (3) · Romania (2) · Australia (1) · China (1) · Israel (1) · Portugal (1) · South Korea (1) · United Arab Emirates (1) · Uzbekistan (1)
Avraham Avital, Prof (1) · Edward Suh, MD (1) · Jaakko M Piitulainen, MD,PhD (1) · Jaakko Piitulainen, M.D., Ph.D. (1) · Jussi Jero, Professor (1) · Kirsten Perrett (1) · Lisa M. Einhorn, MD (1) · Michael J Cunningham, MD (1) · Sumeyra Doluoglu, MD (1) · Tsungju O-Lee, MD (1)
PMID 11375603, PMID 12646834, PMID 20493363, PMID 21422312, PMID 22929115, PMID 27871543, PMID 34292473, PMID 36727868, PMID 38498353, PMID 39476644, PMID 40663994, PMID 41557344, PMID 42452649
R01HD114678 (1)