47 completed, 19 unknown, 13 recruiting, 11 not yet recruiting. 107 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 107 | Completed 47, Unknown 19, Recruiting 13, Not yet recruiting 11, Terminated 8, Withdrawn 5, Active not recruiting 3, Enrolling by invitation 1 |
Follow Thyroid Diseases: new trials by email Literature Review of Thyroid Diseases trials Research Report on Thyroid Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Discontinuation of Low-Dose Levothyroxine in Older Adults With Subclinical Hypothyroidism Levothyroxine Pill, Placebo - Hypothyroidism | Phase 4 | Not yet recruiting | Spyridoula Maraka | 138 | 2027-10-01 | 2026-08-26 |
| A Study of Selpercatinib (LY3527723) in Participants With Rearranged During Transfection (RET)-Altered Cancers in India Selpercatinib - Thyroid Neoplasms, Carcinoma, Non-Small-Cell Lung | Phase 4 | Not yet recruiting | Eli Lilly and Company | 30 | 2026-10-01 | 2026-10-08 |
| An Open-Label Trial of Veligrotug in Participants With Thyroid Eye Disease Who Previously Responded to Teprotumumab veligrotrug (LUMVOA™) - Thyroid Eye Disease | Phase 4 | Not yet recruiting | Viridian Therapeutics, Inc. | 30 | 2026-09-01 | 2026-09-21 |
| A Study of Teprotumumab N01 in Subjects With Active Thyroid Eye Disease Teprotumumab N01, Methylprednisolone - Thyroid Eye Disease | Phase 4 | Recruiting | Innovent Biologics (Suzhou) Co. Ltd. | 92 | 2026-07-30 | 2026-08-13 |
| Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery Dexmedetomidine, Standard General Anesthesia - Thyroid Diseases | Phase 4 | Recruiting | Bach Mai Hospital | 100 | 2026-04-13 | 2026-04-15 |
| Pralsetinib DDI Study in Patients With Advanced or Metastatic Solid Tumors Pralsetinib, CYP3A4, CYP2C8, and CYP2C9 substrates, and hormonal contraceptive - NSCLC (Non-small Cell Lung Cancer), Thyroid Cancer | Phase 4 | Recruiting | Rigel Pharmaceuticals | 12 | 2026-03-04 | 2026-08-10 |
| Xiaojin Pill/Neixiao Luoli Pill for the Treatment of Thyroid Nodules Xiaojin Pill, Neixiao Luoli Pill, Lifestyle Intervention - Thyroid Nodules | Phase 4 | Not yet recruiting | Zhejiang Provincial People's Hospital | 108 | 2026-03-01 | 2026-01-14 |
| Application of Mitoxantrone Hydrochloride Injection in Transoral Robotic Thyroid Cancer Surgery mitoxantrone hydrochloride injection - Papillary Thyroid Cancer | Phase 4 | Not yet recruiting | Daping Hospital and the Research Institute of Surgery of the Third Military Medical University | 114 | 2026-02-01 | 2026-01-21 |
| Comparison of the Efficacy and Safety of 4 vs. 8 Treatments With Tepezza (Teprotumumab) for Thyroid Eye Disease Teprotumumab Injection [Tepezza] - Thyroid Eye Disease, Thyroid Eye Disease, TED | Phase 4 | Not yet recruiting | Sheba Medical Center | 40 | 2026-01-01 | 2025-12-30 |
| Levothyroxine Dosing in Neonatal Congenital Hypothyroidism Levothyroxine - Congenital Hypothyroidism | Phase 4 | Completed | Menoufia University | 101 | 2025-11-02 | 2026-08-10 |
| Sore Throat After Open Neck Elective Surgery Hydrocortisone Acetate 1% Ointment, Lidocaine hydrochloride 0,05% with chlorhexidine - Postoperative Sore Throat, Cough, Hoarseness, Thyroid and Parathyroid Surgery | Phase 4 | Recruiting | Saint Petersburg State University, Russia | 764 | 2025-09-15 | 2026-04-13 |
| Comparison of Two Timings of Levothyroxine Intake in Hypothyroid Patients: A Cross-over Randomized Control Trial Levothyroxine Pill - Hypothyroidism Primary | Phase 4 | Active not recruiting | Elyes Kamoun | 102 | 2025-07-24 | 2026-10-28 |
| Genotype-Driven Neoadjuvant Therapy for Locally Advanced Thyroid Cancer: A Real-World Cohort Study Dabrafenib, Trametinib, Selpercatinib - Thyroid Neoplasms | Phase 4 | Not yet recruiting | Fujian Medical University | 335 | 2025-07-01 | 2025-06-08 |
| Evaluation of the Efficacy and Safety Observation of IBI311 Treatment in Patients With Inactive TAO IBI311, Follew-up - Thyroid Associated Ophthalmopathies | Phase 4 | Recruiting | Shanghai Changzheng Hospital | 50 | 2025-04-15 | 2025-09-03 |
| Efficacy and Safety of Sequential Hormone Therapy and Tetuzumab Therapy in Patients With Moderate to Severe TAO in the Active Stage After Glucocorticoid Treatment. IBI311, Glucocorticoids - Thyroid Associated Ophthalmopathies | Phase 4 | Recruiting | Shanghai Changzheng Hospital | 96 | 2025-04-15 | 2025-09-03 |
| The Safety and Efficacy of Sequential Hormone Therapy and IBI311 Therapy in Patients With Active Moderate to Severe TAO in the Initial Treatment. IBI311, Glucocorticoids - Thyroid Associated Ophthalmopathies | Phase 4 | Recruiting | Shanghai Changzheng Hospital | 64 | 2025-04-10 | 2025-09-03 |
| A Study on the Combined Use of Tocilizumab and Flupentixol-Melitracen in the Treatment of Thyroid-Associated Ophthalmopathy Tocilizumab(400mg) combined with Flupentixol Melitracen(0.5mg:10mg), Tocilizumab(400mg) - Thyroid-Associated Ophthalmopathy | Phase 4 | Recruiting | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | 60 | 2024-12-12 | 2025-04-16 |
| Levothyroxine Intervention in Pregnant Women with TSH （2.5 MIU/L-upper Limit of Reference Range） and Negative Thyroid Peroxidase Antibody Levothyroxine Sodium (LT4) Tablets, Placebo - Thyroid Abnormalities, Pregnant Woman | Phase 4 | Not yet recruiting | Yang ZHANG | 400 | 2024-10-25 | 2024-10-23 |
| Efficacy and Safety of Prunella Oral Liquid in the Treatment of Thyroid Nodules regular dose of JiRui® Prunella oral liquid, 2x regular dose of JiRui® Prunella oral liquid, regular dose of placebo - Thyroid Nodule | Phase 4 | Recruiting | Xintian Pharmaceutical | 234 | 2024-07-30 | 2026-03-24 |
| Aprepitant and Ondansetron Monotherapy or Combination for Postoperative Nausea and Vomiting in Thyroid Cancer Ondansetron 8mg, Aprepitant 125 mg - Thyroid Cancer | Phase 4 | Completed | The First Affiliated Hospital of Zhengzhou University | 600 | 2024-07-01 | 2025-01-22 |
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Hypothyroidism (28) · Graves Ophthalmopathy (25) · Thyroid Neoplasms (20) · Graves Disease (15) · Thyroid Nodule (7) · Goiter (6) · Hyperthyroidism (6) · Congenital Hypothyroidism (3) · Insulin Resistance (3) · Insulin-Like Growth Factor I, Resistance To (3) · Recurrence (3) · Carcinoma, Medullary (2) · Carcinoma, Non-Small-Cell Lung (2) · Endocrine System Diseases (2)
Endocrine System Diseases (105) · Immune System Diseases (38) · Autoimmune Diseases (37) · Goiter (36) · Orbital Diseases (36) · Exophthalmos (35) · Eye Diseases (35) · Hyperthyroidism (34) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (29) · Genetic Diseases, Inborn (29) · Endocrine Gland Neoplasms (26) · Head and Neck Neoplasms (26) · Neoplasms by Site (26) · Eye Diseases, Hereditary (25)
Thyroxine (25) · Methylprednisolone (7) · Methimazole (5) · Prednisone (5) · Sodium Chloride (5) · Glucocorticoids (4) · Propranolol (3) · lenvatinib (3) · teprotumumab (3) · Bimatoprost (2) · Metformin (2) · Prednisolone (2) · Saline Solution (2) · Tablets (2) · Thyrotropin Alfa (2)
Shanghai Changzheng Hospital (3) · Amgen (2) · Aristotle University Of Thessaloniki (2) · Copenhagen University Hospital at Herlev (2) · Saint Petersburg State University, Russia (2) · Sanofi (2) · Shandong Provincial Hospital (2) · University of California, Los Angeles (2) · Yonsei University (2) · Ankara University (1) · Assiut University (1) · Bach Mai Hospital (1) · Baylor College of Medicine (1) · Bracco Diagnostics, Inc (1) · Brazilian Society of Head and Neck Surgery (1)
China (24) · United States (23) · Italy (5) · Denmark (4) · France (4) · India (4) · Netherlands (4) · Russia (4) · South Korea (4) · Spain (4) · United Kingdom (4) · Canada (3) · Germany (3) · Sweden (3) · Australia (2)
Alex Tessnow, MD (1) · Alexandria McDow, MD (1) · Andrea L. Kossler, M.D. (1) · Anne R. Cappola, M.D., Sc.M. (1) · Assimina Galli-Tsinopoulou, Assoc Prof (1) · Birte Nygaard (1) · Birte Nygaard, Md, PhD (1) · Chuanming Zheng (1) · Colin M Dayan, MA FRCP PhD (1) · Daniel B Rootman, MSc MD (1) · Daniel Rootman (1)
PMID 10517721, PMID 10683005, PMID 11334386, PMID 11932302, PMID 12656658, PMID 12727961, PMID 12826640, PMID 15247962, PMID 16275864, PMID 16837619, PMID 17284630, PMID 17696828, PMID 17711927, PMID 17923793, PMID 17964598, PMID 18000630, PMID 18366712, PMID 18421188, PMID 18535733, PMID 19138419, PMID 19337012, PMID 19850691, PMID 20039895, PMID 20526530, PMID 20883174, PMID 21175612, PMID 21508145, PMID 21510801, PMID 21568669, PMID 21765997, PMID 22134702, PMID 22356267, PMID 22968823, PMID 23124142, PMID 23155687, PMID 23158484, PMID 23227861, PMID 23448784, PMID 23744563, PMID 23773982, PMID 23844613, PMID 24157158, PMID 24423358, PMID 24606088, PMID 24667391, PMID 24951271, PMID 24969506, PMID 25050903, PMID 25148231, PMID 26700485
2005 (1), 2015 (1), 2019 (1), R01AG081698 (1)