74 completed, 52 unknown, 35 recruiting, 8 not yet recruiting. 90 Not applicable, 7 Phase 4, 4 Phase 2, 3 Phase 3, 1 Phase 1.
Follow Thyroid Nodule: new trials by email Literature Review of Thyroid Nodule trials Research Report on Thyroid Nodule
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules Diagnostic DNA Methylation Signature - Thyroid Gland Nodule | Recruiting | City of Hope Medical Center | 22 | 2027-01-01 | 2026-06-02 | |
| Bethesda Classification and Risk Stratification in Differentiated Thyroid Carcinoma Differentiated Thyroid Carcinoma, Papillary Thyroid Carcinoma | Not yet recruiting | Assiut University | 100 | 2026-10-26 | 2026-10-05 | |
| Educational Videos for Thyroid Surgery Patient Thyroid Surgery Educational Video - Thyroid Cancer, Thyroid Nodule | Not applicable | Not yet recruiting | West China Hospital | 400 | 2026-10-01 | 2026-09-16 |
| Thyroid Health Outcomes Registry for Surgery Thyroid Diseases, Thyroid Neoplasms | Not yet recruiting | Pirogov Russian National Research Medical University | 3000 | 2026-09-01 | 2026-09-10 | |
| A Novel Ultrasound Probe for Thyroid Imaging and Machine Learning Thyroid ultrasound - Thyroid Nodules, Thyroid Abnormalities | Not applicable | Recruiting | Sound Blade Medical Inc. | 30 | 2026-09-01 | 2026-09-01 |
| NIRAF-Guided Parathyroid Identification During Thyroidectomy Wearable Near-Infrared Autofluorescence Imaging System - Hypocalcemia, Hypoparathyroidism | Not applicable | Not yet recruiting | Ss. Cyril and Methodius University of Skopje | 280 | 2026-06-01 | 2026-06-01 |
| Xiaojin Pill/Neixiao Luoli Pill for the Treatment of Thyroid Nodules Xiaojin Pill, Neixiao Luoli Pill, Lifestyle Intervention - Thyroid Nodules | Phase 4 | Not yet recruiting | Zhejiang Provincial People's Hospital | 108 | 2026-03-01 | 2026-01-14 |
| Multimodal Assessment of Malignancy in Atypia of Undetermined Significance in Thyroid Nodules Using Ultrasound and Cytology Whole-Slide Images Histopathology or cytopathology. - Thyroid Nodule | Recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 396 | 2026-03-01 | 2026-04-01 | |
| Thyroid Artery Embolization for the Treatment of Compressive Goiters. Thyroid Artery Embolization - Thyroid Nodules | Not applicable | Recruiting | Université de Sherbrooke | 20 | 2026-01-31 | 2026-01-22 |
| Active Surveillance for Bethesda IV Thyroid Nodules Active surveillance (6, 12, 18, 24, 36, 48, 60 months) - Thyroid Cancer, Thyroid Nodule | Not applicable | Recruiting | Christian Grønhøj Larsen | 165 | 2026-01-16 | 2026-01-27 |
| Efficacy of Lavender Aromatherapy on Anxiety and Pain Reduction During Awake Otolaryngologic Procedures Lavender Aromatherapy, Placebo Aromatherapy - Inferior Turbinate Hypertrophy, Chronic Rhinosinusitis (CRS) | Not applicable | Recruiting | Cedars-Sinai Medical Center | 184 | 2025-12-01 | 2025-12-23 |
| A Study of Multiparametric Ultrasound Imaging Methods Multiparametric ultrasound (mpUS) imaging - Pancreatic Cancer, Thyroid Nodule | Not applicable | Recruiting | Memorial Sloan Kettering Cancer Center | 85 | 2025-11-24 | 2025-12-12 |
| Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules Questionnaire - Thyroid Nodules, Pulsed Field Ablation | Recruiting | M.D. Anderson Cancer Center | 30 | 2025-11-14 | 2026-06-01 | |
| Mortality Benefit of Ultrasound for Thyroid Nodules Identified With PET Imaging: Non-Inferiority Emulated Target Trial Thyroid Ultrasound - Thyroid Nodule (Benign), Thyroid Nodule (Diagnosis) | Completed | Brigham and Women's Hospital | 874 | 2025-10-15 | 2026-08-10 | |
| Thyroid Artery Goitre Embolization Trial A Pilot Study Investigating Thyroid Artery Embolisation as a Treatment for Large Thyroid Nodules Thyroid artery embolization - Thyroid Nodule (Benign), Graves Disease | Not applicable | Recruiting | Royal Berkshire NHS Foundation Trust | 10 | 2025-09-29 | 2025-12-24 |
| Comparing a New 3D Technology Used to Measure Thyroid Nodule Volume to Standard Ultrasound PIUR tUS Infinity Ultrasound - Thyroid Nodules, Thyroid Nodule | Not applicable | Enrolling by invitation | Sarasota Memorial Health Care System | 75 | 2025-09-08 | 2025-09-17 |
| Prospective Evaluation of the Pulse Biosciences nPulse™ Vybrance™ Percutaneous Electrode System nPulse Vybrance Percutaneous Electrode System - Thyroid Nodule, Thyroid Goiter | Not applicable | Recruiting | Pulse Biosciences, Inc. | 100 | 2025-08-21 | 2026-04-15 |
| Microvascular Profiling of Nodules in the Thyroid Gland Thyroid Nodular Disease | Recruiting | Copenhagen University Hospital, Rigshospitalet | 50 | 2025-08-15 | 2025-11-28 | |
| Safety & Feasibility of Ultrasound-assisted Non-invasive Measurement of Compressibility of the Thyroid Gland in Patients Scheduled for Surgical Removal CPMX1 - Thyroid Nodule (Diagnosis) | Not applicable | Recruiting | Insel Gruppe AG, University Hospital Bern | 30 | 2025-08-15 | 2025-08-19 |
| Effect of a Nature-View Curtain on Pain, Anxiety, and Fear During Thyroid Biopsy Nature-View Curtain Visual Distraction - Thyroid Nodule (Diagnosis) | Not applicable | Completed | Dicle University | 100 | 2025-06-01 | 2026-08-27 |
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Thyroid Neoplasms (68) · Thyroid Diseases (25) · Goiter (16) · Disease (10) · Goiter, Nodular (6) · Hyperthyroidism (6) · Thyroid Cancer, Papillary (6) · Graves Disease (4) · Thyroiditis (4) · Hypocalcemia (3) · Postoperative Complications (3) · Anxiety Disorders (2) · Euthyroid Goiter (2) · Hypoparathyroidism (2)
Endocrine Gland Neoplasms (183) · Endocrine System Diseases (183) · Head and Neck Neoplasms (183) · Neoplasms by Site (183) · Neoplasms (181) · Thyroid Diseases (158) · Thyroid Neoplasms (115) · Pathological Conditions, Signs and Symptoms (22) · Pathologic Processes (16) · Neoplasms by Histologic Type (11) · Neoplasms, Glandular and Epithelial (10) · Immune System Diseases (8) · Metabolic Diseases (8) · Nutritional and Metabolic Diseases (8) · Adenocarcinoma (7)
Thyroidectomy (7) · Radiofrequency Ablation (6) · Biopsy, Fine-Needle (5) · Transurethral Resection of Prostate (5) · Ultrasonography (4) · Elasticity Imaging Techniques (3) · Amoxicillin-Potassium Clavulanate Combination (2) · Bupivacaine (2) · High-Energy Shock Waves (2) · Metformin (2) · Watchful Waiting (2) · Acetaminophen (1) · Anterior Temporal Lobectomy (1) · Artificial Intelligence (1) · Biopsy (1)
Assiut University (8) · Bezmialem Vakif University (3) · Chinese PLA General Hospital (3) · Inha University Hospital (3) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (3) · The University of Hong Kong (3) · Umraniye Education and Research Hospital (3) · Centre Hospitalier Universitaire de Nīmes (2) · Copenhagen University Hospital, Rigshospitalet (2) · Dicle University (2) · Hadassah Medical Organization (2) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (2) · Istanbul University (2) · Kahramanmaras Sutcu Imam University (2) · Khon Kaen University (2)
United States (40) · China (27) · Turkey (Türkiye) (15) · Italy (10) · South Korea (8) · Denmark (7) · Canada (6) · France (6) · Israel (6) · Egypt (5) · Hong Kong (4) · Brazil (3) · Germany (3) · Netherlands (3) · Sweden (3)
David C Shonka, MD (2) · Dingcun Luo (2) · Jingliang Ruan, Ph.D. (2) · Ling Zhan, Doctor (2) · Naykky Singh Ospina (2) · Ralph Tufano, MD (2) · Yukun Luo (2) · Abdullah Atyah Ali, Ass.Lecture General Surgery (1) · Ahmet Selcuk Can, MD (1) · Alexander Stojadinovic, MD (1) · Alfonso Vidal-Casariego, MD (1) · Alvaro Sanabria (1) · Amr M Makky, specialist surgical onclogy (1) · Andreas Muth, MD, PhD (1)
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K08CA248972 (2), 2019 (1), K08CA230204 (1), R21CA164112 (1)