86 completed, 30 unknown, 16 recruiting, 5 not yet recruiting. 85 Not applicable, 14 Phase 2, 8 Phase 3, 2 Phase 1, 2 Phase 4.
Follow Temporomandibular Disorder: new trials by email Literature Review of Temporomandibular Disorder trials Research Report on Temporomandibular Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| R01_Pilot Jaw Muscle Phenotypes Local Heat Therapy - Chronic TMD Pain, Temporomandibular Disorder | Not applicable | Recruiting | University of Minnesota | 10 | 2026-10-20 | 2026-10-23 |
| Postural Assessment in Patients With Malocclusions Lateral teleradiography, Temporomandibular assessment with Helkimo Index, Three-dimensional postural assessment - Malocclusion, Temporomandibular Disorder | Not yet recruiting | Andrea Scribante | 64 | 2026-09-01 | 2026-06-23 | |
| Clinical Evaluation of Botulinum Toxin a in the Management of Temporomandibular Myofascial Pain Botulinum Toxin Type A (BoNT-A), 0.9% Normal Saline (Placebo) - Temporomandibular Disorder | Phase 2 | Recruiting | Riphah International University | 118 | 2026-08-15 | 2026-09-29 |
| An Investigation of Cranio-Cervico-Mandibular Factors Predicting the Severity of Temporomandibular Disorders Assessments - Temporomandibular Disorder | Recruiting | sevilay seda bas | 60 | 2026-06-19 | 2026-06-24 | |
| Evaluating Noninvasive Brain Stimulation for TMD Pain: A Feasibility Study Transcutaneous Auricular Neurostimulation, Sham Stimulation - Temporomandibular Disorder | Not applicable | Recruiting | University of Minnesota | 40 | 2026-05-20 | 2026-05-29 |
| An Open Label Study Assessing REN Treatment in Headache Management in Temporomandibular Disorders Nerivio treatment - Temporomandibular Disorder, Orofacial Pain | Not applicable | Recruiting | Theranica | 100 | 2026-05-04 | 2026-10-14 |
| Arthroscopic Lysis and Lavage With and Without Intra-articular Injection of Hyaluronic Acid in Patients With DDwoR in TMJ Arthroscopic lysis and lavage, arthroscopic lysis and lavage with intra-articular injection of hyaluronic acid - TMJ Disc Disorder, Temporomandibular Joint Disc Displacement, Without Reduction | Not applicable | Not yet recruiting | Cairo University | 52 | 2026-05-01 | 2026-05-29 |
| Forward Head Posture Correction Impact on Temporomandibular Dysfunction Denneroll cervical traction orthodontic, stretching and strengthening exercises, Vacuum-formed soft occlusal splint - Temporomandibular Disorder, Forward Head Posture | Not applicable | Not yet recruiting | Shima Abdollah Mohammad Zadeh | 63 | 2025-10-01 | 2024-03-15 |
| Low-Level Laser Auriculotherapy in the Treatment of Myogenic Temporomandibular Disorders and Anxiety Low-level laser auriculotherapy (LLLT-AT), Sham Low-level laser auriculotherapy (sham LLLT-AT), Myofascial release - Temporomandibular Disorder, Anxiety State | Not applicable | Not yet recruiting | Quiropraxia y Equilibrio | 32 | 2025-09-01 | 2025-08-15 |
| Validation and Evaluation of the Mastication Function in Adults: The Functional Six-minute Mastication Test (F-6MMT). Functional 6-minute mastication test - Mastication Disorder, Fatigue | Not yet recruiting | Fundació Universitària del Bages | 514 | 2025-09-01 | 2025-05-15 | |
| Trauma Exposure and Childhood Trauma in Temporomandibular Joint Disorders Temporomandibular Disorder, Temporomandibular Joint Dysfunction | Completed | Gulseren Demir Karakilic | 102 | 2025-05-22 | 2025-12-29 | |
| Botulinumtoxin A as a Treatment for Myalgia and Myofacial Pain in Patient With Temporomandibulardisorders 5U/0,1 ml Botulinum toxin A, 10U/0,1 ml Botulinum toxin A - Temporomandibular Disorder | Phase 3 | Recruiting | Region Stockholm | 90 | 2025-05-01 | 2025-04-24 |
| Effect of Manual Therapy on Temporomandibular Joint Dysfunction Manual Therapy, Sham manual therapy - Temporomandibular Disorder, Neck Pain | Not applicable | Completed | Abant Izzet Baysal University | 48 | 2024-11-01 | 2025-11-25 |
| Efficacy of Therapeutic Exercise and Pain Neurophysiology Education in Temporomandibular Disorders Therapeutic Exercise, Pain Neurophysiology Education - Temporomandibular Disorder | Not applicable | Unknown | University of Alcala | 36 | 2024-09-01 | 2024-07-16 |
| Treatment of Temporomandibular Disorders in Children and Adolsecents Soft occlusal appliance, Jaw exercises, Counseling - Temporomandibular Disorder, Myalgia | Not applicable | Withdrawn | Karolinska Institutet | 2024-09-01 | 2026-05-22 | |
| TMJ Dysfunction: Effects on Proprioception, Pain, and Body Awareness Assessment of temporomandibular dysfunction - Temporomandibular Joint Disorders, Temporomandibular Disorder | Completed | Nagihan Acet | 60 | 2024-08-19 | 2025-11-25 | |
| Temporomandibular Disorders Knowledge, Attitude, and Practice in Egypt KAP survey - Temporomandibular Disorder | Completed | Cairo University | 288 | 2024-06-30 | 2025-05-18 | |
| Computer Guided Visco Supplementation in the Management of Internal Derangement of Temporomandibular Joint Computer guided sodium hyaluronate injections, conventional sodiumhyaluronate injections - Temporomandibular Disorder | Not applicable | Completed | Hams Hamed Abdelrahman | 20 | 2024-05-03 | 2024-10-31 |
| Effect of Chronic Low Back Pain Treatment on Temporomandibular Disorder" Therapeutic Group, Rocabado's Group - Temporomandibular Disorder, Chronic Low-back Pain | Not applicable | Unknown | Medipol University | 40 | 2024-04-11 | 2024-04-03 |
| Neural Mechanisms of Immersive Virtual Reality in Chronic Pain (VR TMD EEG) RelieVRx, Sham-VR, No-VR (natural history control) - Pain, Virtual Reality | Not applicable | Recruiting | University of Maryland, Baltimore | 78 | 2024-04-09 | 2026-07-07 |
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Temporomandibular Joint Disorders (147) · Pain (18) · Facial Pain (13) · Neck Pain (7) · Bruxism (6) · Motor Activity (6) · Temporomandibular Joint Dysfunction Syndrome (6) · Anxiety Disorders (4) · Chronic Pain (4) · Fibromyalgia (4) · Headache (4) · Myalgia (4) · Myofascial Pain Syndromes (4) · Depression (2) · Marijuana Abuse (2)
Jaw Diseases (147) · Mandibular Diseases (147) · Muscular Diseases (147) · Musculoskeletal Diseases (147) · Craniomandibular Disorders (146) · Joint Diseases (146) · Stomatognathic Diseases (146) · Pathological Conditions, Signs and Symptoms (56) · Neurologic Manifestations (53) · Signs and Symptoms (53) · Pain (30) · Nervous System Diseases (19) · Behavior (17) · Mental Disorders (10) · Tooth Diseases (10)
Exercise (7) · Physical Therapy Modalities (5) · Musculoskeletal Manipulations (4) · Myofascial Release Therapy (4) · Botulinum Toxins, Type A (3) · Exercise Therapy (3) · Low-Level Light Therapy (3) · Occlusal Splints (3) · Patient Education as Topic (3) · Acetaminophen (2) · Anti-Inflammatory Agents, Non-Steroidal (2) · Counseling (2) · Ibuprofen (2) · Massage (2) · Restraint, Physical (2)
University of Nove de Julho (9) · Cairo University (7) · Medical University of Silesia (5) · University of Minnesota (5) · Wroclaw Medical University (5) · Hacettepe University (3) · Istanbul Medipol University Hospital (3) · Marmara University (3) · Pomeranian Medical University Szczecin (3) · Riphah International University (3) · Tokat Gaziosmanpasa University (3) · University of Alcala (3) · Bahçeşehir University (2) · Hams Hamed Abdelrahman (2) · Hochschule Osnabruck (2)
Turkey (Türkiye) (41) · United States (14) · Brazil (13) · Poland (12) · Egypt (11) · Spain (9) · France (4) · Italy (4) · Germany (3) · Pakistan (3) · Belgium (2) · China (2) · Denmark (2) · Sweden (2) · Taiwan (2)
Aysenur Tuncer (2) · Ahmed Abdelhamid, PhD (1) · Ahmed ElMelhat, Professor (1) · Aleksandra Nitecka-Buchta, DMD (1) · Alessandra Galhardo (1) · Alexandre F DaSilva, DDS, DMedSc (1) · Alit Stark Inbar, PhD (1) · Andrea Nackley, PhD (1) · Bartosz Dalewski, DMD,PhD (1) · Bartosz Trybulec, PhD (1) · Beatriz M. Bravo, Physiotherapy (1)
PMID 41914053, PMID 12513918, PMID 15895289, PMID 18468272, PMID 18634953, PMID 19089025, PMID 19440300, PMID 2009044, PMID 21119408, PMID 21885906, PMID 23312922, PMID 23640315, PMID 23768273, PMID 23876095, PMID 24482784, PMID 25512839, PMID 25644634, PMID 27313164, PMID 2746531, PMID 29512838, PMID 29519746, PMID 29730613, PMID 30264631, PMID 30891001, PMID 30915015, PMID 30941095, PMID 31139138, PMID 31162824, PMID 31425430, PMID 32035303, PMID 32160378, PMID 32539850, PMID 32632703, PMID 32792449, PMID 33048053, PMID 33464539, PMID 35211184, PMID 35220688, PMID 35751005, PMID 36269028, PMID 36281107, PMID 36407294, PMID 36651343, PMID 37163204, PMID 37479853, PMID 37491568, PMID 37898152, PMID 37924356, PMID 37956741, PMID 38228287
2023 (1), K23DE031807 (1), R01HD096331 (1), R44DE026663 (1), U01DE025633 (1)