23 recruiting, 8 not yet recruiting, 4 completed, 3 active not recruiting. 28 Not applicable, 3 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 28 | Recruiting 15, Not yet recruiting 7, Completed 3, Active not recruiting 2, Enrolling by invitation 1 |
| Phase 2 | 3 | Recruiting 2, Completed 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow Subjective Cognitive Decline (SCD): new trials by email Literature Review of Subjective Cognitive Decline (SCD) trials Research Report on Subjective Cognitive Decline (SCD)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Bedroom Environment Sleep Intervention at Home for Older Adults Living Alone With Memory Concerns Bedroom Environment Tailoring, Sleep Health Education - Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) | Not applicable | Not yet recruiting | Johns Hopkins University | 40 | 2027-02-01 | 2026-10-09 |
| Personalized Brain Health Service and Dementia Prevention Multimodal Lifestyle Intervention, Lifestyle Recommendations and Counseling - Subjective Cognitive Decline (SCD) | Not applicable | Recruiting | Barcelonabeta Brain Research Center, Pasqual Maragall Foundation | 120 | 2026-09-15 | 2026-09-16 |
| PENSA+: Extended Follow-up of a Multimodal Lifestyle Intervention to Prevent Cognitive Decline in APOE-ε4 Carriers Subjective Cognitive Decline (SCD) | Not yet recruiting | Barcelonabeta Brain Research Center, Pasqual Maragall Foundation | 121 | 2026-09-01 | 2026-07-28 | |
| High Frequency Stimulation to Improve Cognition, Mobility, and Affect in Individuals With and Without Subjective Cognitive Decline Experimental -- 16.67 Hz Visual Occlusion, Control - 1Hz Visual Occlusion - Subjective Cognitive Decline (SCD), Healthy Subjects | Not applicable | Recruiting | University of Florida | 60 | 2026-08-14 | 2026-09-23 |
| Chinese Classics Recitation Training in Subjective Cognitive Decline Memory training by Chinese Classics recitation - Subjective Cognitive Decline (SCD), Subjective Cognitive Decline | Not applicable | Recruiting | China Medical University Hospital | 60 | 2026-08-01 | 2026-10-22 |
| Digital Solutions for Predicting the Biological Mechanisms of Alzheimer's Disease Through the Analysis of Risk Factors Digital solution for the prediction of the biological mechanisms of Alzheimer's disease through the analysis of risk factors - Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD) | Not applicable | Recruiting | IRCCS Centro San Giovanni di Dio Fatebenefratelli | 240 | 2026-06-24 | 2026-07-28 |
| Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment Virtual Reality (VR) sessions - Mild Cognitive Impairment, Subjective Cognitive Decline (SCD) | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 10 | 2026-06-18 | 2026-09-02 |
| Physiological Effect of Non-invasive Photobiomodulation on Cognition and Mood in Older Adults With Subjective Cognitive Impairment Photobiomodulation, Sham (No Treatment) - Subjective Cognitive Decline (SCD), Subjective Cognitive Impairment | Not applicable | Not yet recruiting | Baycrest | 80 | 2026-06-01 | 2026-03-03 |
| Expanding Access to Cognitive Health Biomarker Testing at Home Mild Cognitive Impairment (MCI), Alzheimer's Dementia (AD) | Enrolling by invitation | University of Virginia | 100 | 2026-05-18 | 2026-05-19 | |
| Longitudinal Profiling of Plasma-Derived Glial Extracellular Vesicles in Alzheimer's Disease blood sampling - Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 48 | 2026-05-18 | 2026-09-03 |
| Biomarker-based Trial of NPC-1 for Alzheimer's Pathology natural product combination-1 (NPC1) - Alzheimer Disease, Mild Cognitive Impairment (MCI) | Phase 2 | Recruiting | Massachusetts General Hospital | 40 | 2026-04-01 | 2026-10-13 |
| Effect of Acupuncture on Psychoneurological Symptom Cluster in Breast Cancer Survivors electroacupuncture, sham electroacupuncture - Psychoneurological Symptom Cluster(Pain, Insomnia, Anxiety, Fatigue, Depression, Subjective Cognitive Decline), Pain | Not applicable | Not yet recruiting | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine | 228 | 2026-04-01 | 2026-03-19 |
| InRAD Observational Study None, this is a non-interventional observational study - Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI) | Recruiting | Stichting International Registry for Alzheimer's Disease and other Dementias Foundation | 50000 | 2026-03-30 | 2026-10-22 | |
| Lombard Cohort of Brain Health Services Subjective Cognitive Decline (SCD), Functional Cognitive Disorder | Recruiting | University of Milano Bicocca | 1000 | 2026-02-01 | 2026-03-17 | |
| LETHE-AT: a Personalized Multidomain Lifestyle Intervention for Individuals at Increased Risk of Memory Impairment. A tailored hybrid multidomain lifestyle intervention group, Self-guided multimodal lifestyle advice group - Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD) | Not applicable | Not yet recruiting | Medical University of Vienna | 300 | 2026-01-08 | 2026-01-29 |
| Positive Psychology for Early Cognitive Decline: Effects on Cognitive and Brain Function Positive Psychology Intervention, Treatment as usual (TAU) - Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI) | Not applicable | Recruiting | Aristotle University Of Thessaloniki | 128 | 2025-12-17 | 2026-01-07 |
| Personalized Digital Training for COGnitive FITness in Mild Cognitive Impairment RICORDO, S.A.M.B.A. - Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD) | Not applicable | Recruiting | Giovanna Zamboni | 100 | 2025-11-28 | 2026-04-29 |
| Art of Memory for Cognitive Enhancement in the Monza Brain Health Service Art of memory classes, General information on art of memory - Subjective Cognitive Decline (SCD), Alzheimer's Disease | Not applicable | Active not recruiting | University of Milano Bicocca | 80 | 2025-11-24 | 2026-03-18 |
| Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory Problems Active Brainsway H7-Coil Deep TMS System, Sham Brainsway H1-Coil Deep TMS System - Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD) | Not applicable | Recruiting | Rotman Research Institute at Baycrest | 30 | 2025-11-15 | 2025-10-28 |
| FACE Phase II (a Stage II Trial) Cognitive Remediation, Cognitive Remediation II - MCI, Subjective Cognitive Decline (SCD) | Phase 1 / Phase 2 | Recruiting | Stanford University | 80 | 2025-10-31 | 2026-04-24 |
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PMID 11001602, PMID 11124735, PMID 1202204, PMID 14044222, PMID 15324367, PMID 18590364, PMID 21514249, PMID 21514250, PMID 21691143, PMID 24798886, PMID 31039826, PMID 33017671, PMID 34989910, PMID 35616942, PMID 40812823, PMID 40893385, PMID 41092385, PMID 41657474, PMID 42548715, PMID 5349366, PMID 7069156, PMID 8954307, PMID 9153155
P30AG086561 (1)