4 completed, 4 recruiting, 3 not yet recruiting, 3 unknown. 14 Phase 3, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Completed 4, Recruiting 4, Not yet recruiting 3, Unknown 3 |
| Phase 2 | 2 | Completed 1, Not yet recruiting 1 |
Follow Stroke, Acute Ischemic: new trials by email Literature Review of Stroke, Acute Ischemic trials Research Report on Stroke, Acute Ischemic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 Mechanical Endovascular Thrombectomy, Intravenous Thrombolysis, Tenecteplase/Alteplase- depending upon availability at each treating centre - Stroke, Acute Ischemic, Medium Vessel Occlusion | Phase 3 | Not yet recruiting | University of Calgary | 800 | 2026-12-15 | 2026-10-30 |
| ACT-GLOBAL IA Thrombolysis(ACT-REACT-004)Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 Tenecteplase or Alteplase- depending upon availability at each treating centre, Control - Stroke, Acute Ischemic, Endovascular Thrombectomy | Phase 3 | Recruiting | University of Calgary | 1500 | 2026-08-11 | 2026-10-21 |
| INtra-arterial AltEplase folloWing successfuL reperfusIoN After mEchanical Thrombectomy Alteplase, Endovascular thrombectomy - Stroke, Acute Ischemic, Large Vessel Occlusion | Phase 3 | Recruiting | 115 People's Hospital | 416 | 2026-08-01 | 2026-11-09 |
| Isosorbide Mononitrate and Butylphthalide to Reduce the Risk of Disability in Patients With Acute Lacunar Stroke (IMPACT) Isosorbide Mononitrate, Butylphthalide, Isosorbide Mononitrate Placebo - Stroke, Lacunar, Stroke, Acute Ischemic | Phase 3 | Not yet recruiting | Beijing Tiantan Hospital | 3156 | 2025-12-01 | 2025-11-26 |
| Intravenous rhTNK-tPA Before Stroke Thrombectomy in the Extended Time Window Intravenous rhTNK-tPA, Intravenous placebo, Endovascular thrombectomy - Stroke, Acute Ischemic | Phase 3 | Recruiting | Xinqiao Hospital of Chongqing | 820 | 2025-10-21 | 2025-12-31 |
| Intra-Arterial Thrombolysis After SUCCESSful Reperfusion in Anterior Circulation Ischemic Stroke Intra-arterial infusion of Alteplase - Stroke, Acute Ischemic | Phase 3 | Recruiting | Central Hospital, Nancy, France | 626 | 2025-06-01 | 2025-06-05 |
| Tirofiban for Successful Endovascular Stroke Thrombectomy Intraarterial and intravenous tirofiban, Intraarterial and intravenous placebo - Stroke, Acute Ischemic | Phase 2 / Phase 3 | Not yet recruiting | Zhongming Qiu | 712 | 2024-07-31 | 2024-05-16 |
| Cerebroprotective Effect of Melatonin in Stroke Melatonin 10 MG, Placebo - Stroke, Acute Ischemic, Strokes Thrombotic | Phase 3 | Unknown | Coordinación de Investigación en Salud, Mexico | 100 | 2024-03-01 | 2024-03-05 |
| Intravenous Tirofiban Versus Thrombolysis Before Mechanical Thrombectomy in Stroke Tirofiban, Thrombolysis - Stroke, Acute Ischemic | Phase 2 / Phase 3 | Completed | Xinqiao Hospital of Chongqing | 1014 | 2023-11-28 | 2026-09-14 |
| CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2). Intraarterial alteplase - Stroke, Acute Ischemic, Stroke, Acute | Phase 3 | Completed | Hospital Clinic of Barcelona | 440 | 2023-11-18 | 2026-09-18 |
| Intra-arterial Alteplase for Acute Ischemic Stroke After Mechanical Thrombectomy Alteplase - Stroke, Acute Ischemic | Phase 3 | Completed | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 324 | 2023-08-01 | 2026-08-12 |
| Endovascular Thrombectomy With and Without Intravenous Thrombolysis in Extended Time Window Intravenous thrombolysis agents, endovascular thrombectomy - Stroke, Acute Ischemic | Phase 3 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 222 | 2022-12-03 | 2023-02-14 |
| EXtending the Time Window for Thrombolysis in Posterior Circulation Stroke Without Early CT Signs Tissue Plasminogen Activator (Alteplase) - Stroke, Acute Ischemic | Phase 3 | Completed | Second Affiliated Hospital, Zhejiang University, School of Medicine | 234 | 2022-08-17 | 2024-12-18 |
| Mechanical Thrombectomy of Medium Sized Vessels "M2 of MCA". Mechanical thrombectomy, medical treatment - Stroke, Acute Ischemic | Phase 3 | Unknown | Assiut University | 60 | 2021-12-01 | 2021-10-25 |
Ischemic Stroke (14) · Stroke (2) · Cerebral Small Vessel Diseases (1) · Stroke, Lacunar (1) · Thrombotic Stroke (1)
Brain Diseases (14) · Cardiovascular Diseases (14) · Central Nervous System Diseases (14) · Cerebrovascular Disorders (14) · Nervous System Diseases (14) · Vascular Diseases (14) · Stroke (12) · Brain Infarction (1) · Infarction (1) · Ischemia (1) · Necrosis (1) · Pathologic Processes (1) · Pathological Conditions, Signs and Symptoms (1) · Thrombotic Stroke (1)
Tissue Plasminogen Activator (5) · Fibrinolytic Agents (3) · Tenecteplase (2) · Tirofiban (2) · 3-n-butylphthalide (1) · Infusions, Intra-Arterial (1) · Melatonin (1) · isosorbide-5-mononitrate (1)
Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · University of Calgary (2) · Xinqiao Hospital of Chongqing (2) · 115 People's Hospital (1) · Assiut University (1) · Beijing Tiantan Hospital (1) · Central Hospital, Nancy, France (1) · Coordinación de Investigación en Salud, Mexico (1) · Hospital Clinic of Barcelona (1) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (1) · Zhongming Qiu (1)
China (5) · Canada (2) · Australia (1) · France (1) · Mexico (1) · Spain (1) · Vietnam (1)
Bijoy K Menon, MD (2) · Craig Anderson, MD (2) · Ana Morales, MD (1) · Angel Chamorro, MD, PhD (1) · Congguo Yin, Doctor (1) · Daojun Hong, MD (1) · Juan F Arenillas, MD (1) · Laura Dorado, MD (1) · Lluis Morales, MD (1) · Maria Herrera, MD (1)
PMID 39500603, PMID 33464335, PMID 35143603, PMID 35943471, PMID 39357896, PMID 40174223, PMID 41339082, PMID 41778584, PMID 42096239, PMID 42262770, PMID 42265863, PMID 42439416
2023 (2)