19 completed, 4 terminated, 1 withdrawn. 11 Phase 1, 6 Not applicable, 5 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 11 | Completed 8, Terminated 2, Withdrawn 1 |
| Not applicable | 6 | Completed 6 |
| Phase 2 | 5 | Completed 3, Terminated 1, Withdrawn 1 |
| Phase 3 | 1 | Completed 1 |
Follow Stage IIIC Rectal Cancer: new trials by email Literature Review of Stage IIIC Rectal Cancer trials Research Report on Stage IIIC Rectal Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer Binimetinib, Encorafenib, Nivolumab - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 | Terminated | University of California, San Francisco | 2 | 2020-08-31 | 2023-01-09 |
| Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer Best Practice, Laboratory Biomarker Analysis, Supportive Care - Acute Myeloid Leukemia, Brain Glioblastoma | Not applicable | Completed | Stanford University | 128 | 2017-08-08 | 2025-01-24 |
| CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery 6,8-bis(benzylthio)octanoic acid, fluorouracil, pharmacological study - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | Wake Forest University Health Sciences | 19 | 2015-01-06 | 2023-08-07 |
| Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer intensity-modulated radiation therapy, fluorouracil, oxaliplatin - Mucinous Adenocarcinoma of the Rectum, Recurrent Rectal Cancer | Phase 1 | Completed | Virginia Commonwealth University | 14 | 2014-12-04 | 2021-07-20 |
| Programs to Support You During Chemotherapy (Pro-You) Yoga Skills Training (YST), questionnaire administration, fatigue and depressive symptom assessment and management - Depressive Symptoms, Fatigue | Not applicable | Completed | Vanderbilt-Ingram Cancer Center | 3 | 2014-08-01 | 2015-06-23 |
| Genetic Mutations in Blood and Tissue Samples in Predicting Response to Treatment in Patients With Locally Advanced Rectal Cancer Undergoing Chemoradiation cytology specimen collection procedure, laboratory biomarker analysis - Mucinous Adenocarcinoma of the Rectum, Recurrent Rectal Cancer | Completed | Fox Chase Cancer Center | 43 | 2014-07-01 | 2024-05-02 | |
| Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung Cancers educational intervention, telephone-based intervention, quality-of-life assessment - Healthy Subject, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter | Not applicable | Completed | City of Hope Medical Center | 200 | 2013-10-29 | 2026-10-01 |
| Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal Cancer Undergoing Chemotherapy cytology specimen collection procedure, laboratory biomarker analysis, questionnaire administration - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Terminated | Fox Chase Cancer Center | 6 | 2013-10-01 | 2018-02-07 | |
| Bevacizumab, Fluorouracil, Leucovorin Calcium, and Oxaliplatin Before Surgery in Treating Patients With Stage II-III Rectal Cancer bevacizumab, oxaliplatin, leucovorin calcium - Mucinous Adenocarcinoma of the Rectum, Signet Ring Adenocarcinoma of the Rectum | Phase 2 | Terminated | University of Southern California | 17 | 2013-08-02 | 2026-07-01 |
| PET-MRI in Diagnosing Patients With Colon or Rectal Cancer positron emission tomography, computed tomography, magnetic resonance imaging - Recurrent Colon Cancer, Recurrent Rectal Cancer | Not applicable | Completed | Case Comprehensive Cancer Center | 15 | 2013-04-01 | 2021-05-18 |
| Akt Inhibitor MK2206 in Treating Patients With Previously Treated Colon or Rectal Cancer That is Metastatic or Locally Advanced and Cannot Be Removed by Surgery Akt Inhibitor MK2206, Laboratory Biomarker Analysis, Pharmacological Study - Colon Mucinous Adenocarcinoma, Colon Signet Ring Cell Adenocarcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 18 | 2013-03-01 | 2019-09-20 |
| Adherence to Survivorship Care Guidelines in Health Care Providers for Non-Small Cell Lung Cancer and Colorectal Cancer Survivor Care educational intervention, medical chart review - Adenocarcinoma of the Lung, Mucinous Adenocarcinoma of the Colon | Not applicable | Completed | Fox Chase Cancer Center | 1440 | 2013-01-01 | 2017-04-06 |
| Survivorship Care Planning in Patients With Colorectal or Non-Small Cell Lung Cancer educational intervention, questionnaire administration, quality-of-life assessment - Stage I Colon Cancer, Stage I Rectal Cancer | Not applicable | Completed | City of Hope Medical Center | 30 | 2013-01-01 | 2013-12-18 |
| Trametinib, Fluorouracil, and Radiation Therapy Before Surgery in Treating Patients With Stage II-III Rectal Cancer trametinib, fluorouracil, radiation therapy - Recurrent Rectal Cancer, Stage IIA Rectal Cancer | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 19 | 2012-11-26 | 2023-09-18 |
| Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies oxaliplatin, irinotecan hydrochloride, leucovorin calcium - Acinar Cell Adenocarcinoma of the Pancreas, Adenocarcinoma of the Gallbladder | Phase 1 | Completed | University of Chicago | 79 | 2012-03-26 | 2020-05-08 |
| Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer That Can Be Removed in Surgery paricalcitol, radiation therapy, laboratory biomarker analysis - Mucinous Adenocarcinoma of the Rectum, Stage IIA Rectal Cancer | Phase 1 | Terminated | Wake Forest University Health Sciences | 2 | 2010-08-01 | 2018-07-02 |
| Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors Gamma-Secretase Inhibitor RO4929097, Cediranib Maleate, Pharmacological Study - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2010-05-01 | 2014-12-23 |
| Erlotinib Hydrochloride in Treating Patients With Stage I-III Colorectal Cancer or Adenoma erlotinib hydrochloride, placebo, laboratory biomarker analysis - Adenomatous Polyp, Recurrent Colon Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 45 | 2008-07-01 | 2015-01-06 |
| SB-715992 in Treating Patients With Advanced or Metastatic Colorectal Cancer ispinesib, laboratory biomarker analysis - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 2 | Completed | National Cancer Institute (NCI) | 64 | 2005-01-01 | 2015-03-02 |
| GTI-2040, Oxaliplatin, and Capecitabine in Treating Patients With Locally Advanced or Metastatic Colorectal Cancer or Other Solid Tumors GTI-2040, oxaliplatin, capecitabine - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2004-05-01 | 2013-03-27 |
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Rectal Neoplasms (24) · Colonic Neoplasms (18) · Pancreatic Neoplasms (5) · Carcinoma, Non-Small-Cell Lung (4) · Carcinoma, Renal Cell (3) · Stomach Neoplasms (3) · Breast Neoplasms (2) · Colorectal Neoplasms (2) · Melanoma (2) · Ovarian Neoplasms (2) · Urinary Bladder Neoplasms (2) · Adenocarcinoma of Lung (1) · Adenomatous Polyps (1) · Astrocytoma (1) · Bile Duct Neoplasms (1)
Digestive System Diseases (24) · Digestive System Neoplasms (24) · Gastrointestinal Diseases (24) · Gastrointestinal Neoplasms (24) · Intestinal Diseases (24) · Intestinal Neoplasms (24) · Neoplasms (24) · Neoplasms by Site (24) · Rectal Diseases (24) · Colorectal Neoplasms (22) · Colonic Diseases (18) · Endocrine Gland Neoplasms (5) · Endocrine System Diseases (5) · Lung Diseases (5) · Neoplasms by Histologic Type (5)
Fluorouracil (10) · Oxaliplatin (8) · Leucovorin (6) · Early Intervention, Educational (3) · Irinotecan (3) · Methods (3) · Radiation (3) · Radiotherapy (3) · Bevacizumab (2) · Erlotinib Hydrochloride (2) · dehydroftorafur (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Capecitabine (1) · Fluorodeoxyglucose F18 (1)
National Cancer Institute (NCI) (8) · Fox Chase Cancer Center (3) · City of Hope Medical Center (2) · Wake Forest University Health Sciences (2) · Case Comprehensive Cancer Center (1) · Ohio State University Comprehensive Cancer Center (1) · Roswell Park Cancer Institute (1) · Stanford University (1) · University of California, San Francisco (1) · University of Chicago (1) · University of Southern California (1) · Vanderbilt-Ingram Cancer Center (1) · Virginia Commonwealth University (1)
United States (23) · Canada (1)
Afsaneh Barzi (1) · Betty Ferrell (1) · Caio Rocha Lima, MD (1) · Chloe E Atreya, MD, PhD (1) · Crystal Denlinger, MD (1) · Daniel Haller (1) · Edmund Kopetz (1) · Efrat Dotan (1) · Emma C Fields, MD (1) · George Yacoub, MD (1) · Hedy Kindler (1) · Henry Pitot (1) · Joshua Meyer (1) · Manali Patel (1) · Raj Paspulati, MD (1)
PMID 32649004, PMID 34749008, PMID 35771552
P30CA006927 (2), N01CM00039 (1), N01CN35160 (1), P30CA012197 (1), P30CA014089 (1), P30CA016056 (1), P30CA016059 (1), P30CA016672 (1), P30CA068485 (1), U01CA062505 (1), U01CA070095 (1), U01CA132123 (1), U10CA021115 (1), U10CA025224 (1)