29 completed, 28 active not recruiting, 26 recruiting, 10 terminated. 57 Phase 2, 36 Phase 1, 22 Phase 3, 2 Early Phase 1.
Follow dehydroftorafur: new trials by email Literature Review of dehydroftorafur trials Research Report on dehydroftorafur
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SMAD4 Tailored Neoadjuvant Therapy for the Treatment of Resectable and Borderline Resectable Pancreatic Ductal Adenocarcinoma, SMART-PANC Trial Biospecimen Collection, Computed Tomography, Electronic Health Record Review - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Not yet recruiting | Northwestern University | 125 | 2027-02-03 | 2026-08-06 |
| Testing Safe Doses of Anti-Cancer Medicines, 5-Flurouracil (5-FU) and Tretinoin (ATRA), Added to the Usual Cancer Treatment of Ependymoma Biospecimen Collection, Echocardiography Test, Fluorouracil - Childhood Posterior Fossa Ependymoma | Phase 1 / Phase 2 | Not yet recruiting | Children's Oncology Group | 70 | 2026-12-11 | 2026-09-30 |
| Ivonescimab and ADG126, Alone, and in Combination With Leucovorin and Fluorouracil or FOLFIRI Regimen for the Treatment of Microsatellite Stable Advanced/Metastatic Colorectal Cancer Biospecimen Collection, Computed Tomography, Fluorouracil - Advanced Microsatellite Stable Colorectal Carcinoma, Metastatic Microsatellite Stable Colorectal Carcinoma | Phase 1 | Not yet recruiting | City of Hope Medical Center | 30 | 2026-12-01 | 2026-09-02 |
| DCE-MRI for Neoadjuvant Treatment Assessment in Patients With Borderline Resectable Pancreatic Cancer Biospecimen Collection, Computed Tomography, Dynamic Contrast-Enhanced Magnetic Resonance Imaging - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 1 / Phase 2 | Recruiting | Ohio State University Comprehensive Cancer Center | 50 | 2026-10-01 | 2026-10-05 |
| Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Appendix Carcinoma, Metastatic Colorectal Carcinoma | Phase 3 | Recruiting | City of Hope Medical Center | 129 | 2026-10-01 | 2026-09-25 |
| AB801 in Combination With Chemotherapy and Immunotherapy for the Treatment of Patients With Borderline Resectable, Locally Advanced or Metastatic Cholangiocarcinoma or Pancreatic Cancer Biopsy Procedure, Cisplatin, Computed Tomography - Borderline Resectable Pancreatic Ductal Adenocarcinoma, Locally Advanced Cholangiocarcinoma | Phase 1 | Recruiting | Jonsson Comprehensive Cancer Center | 46 | 2026-05-29 | 2026-08-20 |
| Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations Biospecimen Collection, Computed Tomography, Fluorouracil - Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 3 | Recruiting | SWOG Cancer Research Network | 94 | 2026-05-13 | 2026-05-22 |
| Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy Biospecimen Collection, Capecitabine, Diltiazem Hydrochloride - Malignant Digestive System Neoplasm | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 60 | 2026-04-30 | 2026-06-02 |
| NALIRIFOX Before Surgery for the Treatment of Borderline Resectable Pancreatic Ductal Adenocarcinoma, Nectar Trial Biospecimen Collection, Computed Tomography, Fluorouracil - Borderline Resectable Pancreatic Ductal Adenocarcinoma | Phase 2 | Recruiting | Roswell Park Cancer Institute | 20 | 2026-03-02 | 2026-09-21 |
| Pegcetacoplan in Combination With Modified FOLFIRINOX for the Treatment of Metastatic Pancreatic Ductal Adenocarcinoma Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Pancreatic Ductal Adenocarcinoma, Stage IV Pancreatic Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Roswell Park Cancer Institute | 35 | 2026-02-16 | 2026-08-19 |
| Neoadjuvant Therapy for the Treatment of Gastroesophageal Junction and Gastric Cancers Capecitabine, Docetaxel, Fluorouracil - Clinical Stage I Gastric Cancer AJCC v8, Clinical Stage II Gastric Cancer AJCC v8 | Phase 1 | Withdrawn | Ohio State University Comprehensive Cancer Center | 2025-12-31 | 2025-02-07 | |
| Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study Biospecimen Collection, Cisplatin, Computed Tomography - Muscle Invasive Bladder Urothelial Carcinoma, Stage II Bladder Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 486 | 2025-10-07 | 2026-10-23 |
| Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer Biopsy Procedure, Biospecimen Collection, Capecitabine - Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8 | Phase 3 | Recruiting | NRG Oncology | 356 | 2025-08-21 | 2026-08-25 |
| Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer Bevacizumab, Biopsy Procedure, Biospecimen Collection - Metastatic Colorectal Adenocarcinoma, Stage III Colorectal Cancer AJCC v8 | Phase 1 | Recruiting | National Cancer Institute (NCI) | 24 | 2025-06-23 | 2026-09-09 |
| Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial Biospecimen Collection, Cisplatin, Computed Tomography - Non-Muscle Invasive Bladder Urothelial Carcinoma, Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 160 | 2025-06-03 | 2026-10-19 |
| FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery Balstilimab, Biospecimen Collection, Botensilimab - Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8 | Phase 2 | Recruiting | City of Hope Medical Center | 26 | 2025-05-20 | 2026-06-29 |
| Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer Abemaciclib, Biopsy Procedure, Biospecimen Collection - Metastatic Microsatellite Stable Colorectal Carcinoma, Refractory Microsatellite Stable Colorectal Carcinoma | Phase 1 | Recruiting | National Cancer Institute (NCI) | 39 | 2025-04-18 | 2026-10-15 |
| Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancer Biopsy, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Peritoneum | Phase 1 | Active not recruiting | Arjun Mittra | 9 | 2024-12-31 | 2026-10-09 |
| Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer Biopsy, Biospecimen Collection, Computed Tomography - Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 2 | Active not recruiting | Mayo Clinic | 24 | 2024-12-06 | 2026-06-18 |
| Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients Biopsy, Calcipotriene, Fluorouracil - Actinic Keratosis | Phase 2 | Active not recruiting | University of Arizona | 56 | 2024-07-02 | 2025-09-24 |
Showing 20 of 101. Sign in to see all of them.
Pancreatic Neoplasms (18) · Colorectal Neoplasms (16) · Rectal Neoplasms (11) · Colonic Neoplasms (8) · Stomach Neoplasms (6) · Adenocarcinoma Of Esophagus (5) · Urinary Bladder Neoplasms (5) · Anus Neoplasms (4) · Neoplasm Metastasis (4) · Ovarian Neoplasms (4) · Cholangiocarcinoma (3) · Esophageal Neoplasms (3) · Gallbladder Neoplasms (3) · Gastrointestinal Neoplasms (3) · Squamous Cell Carcinoma of Head and Neck (3)
National Cancer Institute (NCI) (29) · M.D. Anderson Cancer Center (12) · City of Hope Medical Center (6) · ECOG-ACRIN Cancer Research Group (6) · Mayo Clinic (6) · NRG Oncology (5) · Roswell Park Cancer Institute (5) · Jonsson Comprehensive Cancer Center (4) · Children's Oncology Group (3) · OHSU Knight Cancer Institute (3) · SWOG Cancer Research Network (3) · University of Nebraska (3) · Northwestern University (2) · Ohio State University Comprehensive Cancer Center (2) · Academic and Community Cancer Research United (1)
United States (98) · Canada (11) · Puerto Rico (10) · Australia (4) · South Africa (2) · Belgium (1) · Brazil (1) · China (1) · Germany (1) · Hong Kong (1) · Israel (1) · Japan (1) · New Zealand (1) · Norway (1) · Peru (1)
Christos Fountzilas (2) · Mariela Blum (2) · Marwan Fakih (2) · Marwan G Fakih (2) · Parminder Singh (2) · Steven H Lin (2) · Zev A Wainberg (2) · Adam J Esbenshade (1) · Afsaneh Barzi, MD (1) · Al B Benson (1) · Ann Raldow (1) · Anne M Noonan, MBBChBAO, MSc (1) · Anthony Shields (1) · Ardaman Shergill (1) · Arjun Mittra, MD (1)
PMID 21997132, PMID 22178121, PMID 23233715, PMID 25926352, PMID 27978579, PMID 28006055, PMID 30975630, PMID 31268130, PMID 31553639, PMID 31618129, PMID 31657981, PMID 31811950, PMID 32740235, PMID 32939319, PMID 33142018, PMID 33356421, PMID 33370024, PMID 33475684, PMID 33835977, PMID 33909232, PMID 34196693, PMID 34272087, PMID 34562230, PMID 34874751, PMID 34965890, PMID 34980020, PMID 35602670, PMID 36221952, PMID 36963200, PMID 37073741, PMID 37129197, PMID 37222189, PMID 37266942, PMID 37478389, PMID 37598723, PMID 38131628, PMID 38315963, PMID 38445914, PMID 39816915, PMID 39841295, PMID 39863139, PMID 39938471, PMID 39945382, PMID 40953502, PMID 41005671, PMID 41133726, PMID 41880612, PMID 42456089, PMID 42525921
U10CA180820 (12), U10CA180868 (9), U10CA180888 (7), P30CA033572 (5), U10CA180886 (4), P30CA036727 (3), U10CA021115 (3), U10CA021661 (3), U10CA180821 (3), P30CA015083 (2), P30CA060553 (2), U01CA069912 (2), U10CA032102 (2), U10CA098543 (2), UM1CA186689 (2)