7 completed, 1 terminated, 1 withdrawn. 9 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 9 | Completed 7, Terminated 1, Withdrawn 1 |
| Phase 2 | 1 | Withdrawn 1 |
Follow Stage IIIA Rectal Cancer: new trials by email Literature Review of Stage IIIA Rectal Cancer trials Research Report on Stage IIIA Rectal Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer Binimetinib, Encorafenib, Nivolumab - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 | Terminated | University of California, San Francisco | 2 | 2020-08-31 | 2023-01-09 |
| CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery 6,8-bis(benzylthio)octanoic acid, fluorouracil, pharmacological study - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | Wake Forest University Health Sciences | 19 | 2015-01-06 | 2023-08-07 |
| Phase I Study of Neoadjuvant Radiotherapy With 5-Fluorouracil for Rectal Cancer intensity-modulated radiation therapy, fluorouracil, oxaliplatin - Mucinous Adenocarcinoma of the Rectum, Recurrent Rectal Cancer | Phase 1 | Completed | Virginia Commonwealth University | 14 | 2014-12-04 | 2021-07-20 |
| Trametinib, Fluorouracil, and Radiation Therapy Before Surgery in Treating Patients With Stage II-III Rectal Cancer trametinib, fluorouracil, radiation therapy - Recurrent Rectal Cancer, Stage IIA Rectal Cancer | Phase 1 | Completed | Ohio State University Comprehensive Cancer Center | 19 | 2012-11-26 | 2023-09-18 |
| Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies oxaliplatin, irinotecan hydrochloride, leucovorin calcium - Acinar Cell Adenocarcinoma of the Pancreas, Adenocarcinoma of the Gallbladder | Phase 1 | Completed | University of Chicago | 79 | 2012-03-26 | 2020-05-08 |
| Gamma-Secretase Inhibitor RO4929097 and Cediranib Maleate in Treating Patients With Advanced Solid Tumors Gamma-Secretase Inhibitor RO4929097, Cediranib Maleate, Pharmacological Study - Adult Anaplastic Astrocytoma, Adult Anaplastic Ependymoma | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2010-05-01 | 2014-12-23 |
| A Phase I, Pharmacological, and Biological Study of OSI-774 in Combination With FOLFOX 4 (5-FU, Leucovorin, and Oxaliplatin) and Bevacizumab (Avastin) in Patients With Advanced Colorectal Cancer erlotinib hydrochloride, fluorouracil, leucovorin calcium - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | National Cancer Institute (NCI) | 24 | 2003-06-01 | 2013-09-30 |
| Chemotherapy, Radiation Therapy, and Surgery in Treating Patients With Locally Advanced Rectal Cancer fluorouracil, oxaliplatin, radiation therapy - Adenocarcinoma of the Rectum, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 1999-05-01 | 2013-01-10 |
| Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With Untreated Metastatic Pancreatic Cancer Fluorouracil, Irinotecan Hydrochloride, Laboratory Biomarker Analysis - Colon Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma | Phase 1 / Phase 2 | Withdrawn | Roswell Park Cancer Institute | 2016-05-20 |
Rectal Neoplasms (9) · Colonic Neoplasms (6) · Pancreatic Neoplasms (3) · Astrocytoma (1) · Bile Duct Neoplasms (1) · Brain Neoplasms (1) · Breast Neoplasms (1) · Breast Neoplasms, Male (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Renal Cell (1) · Colorectal Neoplasms (1) · Ependymoma (1) · Gallbladder Neoplasms (1) · Glioblastoma (1) · Glioma (1)
Digestive System Diseases (9) · Digestive System Neoplasms (9) · Gastrointestinal Diseases (9) · Gastrointestinal Neoplasms (9) · Intestinal Diseases (9) · Intestinal Neoplasms (9) · Neoplasms (9) · Neoplasms by Site (9) · Rectal Diseases (9) · Colorectal Neoplasms (8) · Colonic Diseases (6) · Endocrine Gland Neoplasms (3) · Endocrine System Diseases (3) · Pancreatic Diseases (3) · Adenocarcinoma (1)
Fluorouracil (7) · Oxaliplatin (5) · Leucovorin (4) · Irinotecan (2) · Radiation (2) · Radiotherapy (2) · dehydroftorafur (2) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (1) · Bevacizumab (1) · Erlotinib Hydrochloride (1) · Nivolumab (1) · Radiotherapy, Intensity-Modulated (1) · binimetinib (1) · cediranib (1) · devimistat (1)
National Cancer Institute (NCI) (3) · Ohio State University Comprehensive Cancer Center (1) · Roswell Park Cancer Institute (1) · University of California, San Francisco (1) · University of Chicago (1) · Virginia Commonwealth University (1) · Wake Forest University Health Sciences (1)
United States (8) · Canada (1)
Caio Rocha Lima, MD (1) · Chloe E Atreya, MD, PhD (1) · Daniel Haller (1) · Emma C Fields, MD (1) · Hedy Kindler (1) · Sameek Roychowdhury, MD (1) · Sebastien Hotte (1) · Wells Messersmith (1) · Wen Wee Ma (1)
P30CA012197 (1), P30CA016056 (1), P30CA016059 (1), U01CA070095 (1), U01CA132123 (1), U10CA021115 (1)