14 active not recruiting, 14 recruiting, 9 completed, 5 terminated. 14 Not applicable, 14 Phase 2, 7 Phase 1, 7 Phase 3, 2 Early Phase 1.
Follow Stage II Lung Cancer AJCC v8: new trials by email Literature Review of Stage II Lung Cancer AJCC v8 trials Research Report on Stage II Lung Cancer AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing Repeat Radiation Therapy for Recurrent Non-small Cell Lung Cancer Biospecimen Collection, Computed Tomography, Immunotherapy - Locally Recurrent Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 2 | Not yet recruiting | NRG Oncology | 138 | 2026-12-18 | 2026-09-23 |
| Hotspot Stereotactic Ablative Radiotherapy Versus Traditional Stereotactic Ablative Radiotherapy for the Treatment of Early-Stage Non-Small Cell Lung Cancer Biospecimen Collection, Computed Tomography, Lymph Node Biopsy - Early Stage Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Phase 2 | Recruiting | Roswell Park Cancer Institute | 200 | 2026-09-01 | 2026-08-26 |
| New York Better Breathing Study Biospecimen Collection, Electronic Health Record Review, Medical Device Usage and Evaluation - Localized Lung Carcinoma, Stage I Lung Cancer AJCC v8 | Not applicable | Recruiting | Roswell Park Cancer Institute | 100 | 2026-04-20 | 2026-10-26 |
| Testing the Addition of AZD6738 (Ceralasertib) to Immunotherapy to Increase Time Without Cancer for Patients With Non-Small Cell Lung Cancer Biospecimen Collection, Ceralasertib, Computed Tomography - Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 630 | 2025-08-07 | 2026-09-21 |
| Cemiplimab and Fianlimab Before Surgery for the Treatment of Stage IB-IIIB Non-Small Cell Lung Cancer Biospecimen Collection, Cemiplimab, Fianlimab - Lung Non-Small Cell Carcinoma, Stage IB Lung Cancer AJCC v8 | Phase 2 | Recruiting | Mayo Clinic | 60 | 2025-05-02 | 2026-10-29 |
| Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial Biospecimen Collection, Computed Tomography, Durvalumab - Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 3 | Recruiting | National Cancer Institute (NCI) | 306 | 2025-04-01 | 2026-10-19 |
| Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer Surgical Procedure, Cisplatin, Carboplatin - Resectable Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 3 | Active not recruiting | Alliance for Clinical Trials in Oncology | 37 | 2024-12-11 | 2026-09-02 |
| Oral Iloprost for the Prevention of Lung Cancer In Former Smokers Biospecimen Collection, Bronchial Brush Biopsy, Bronchoscopy - Bronchial Epithelial Dysplasia, Chronic Obstructive Pulmonary Disease | Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2024-06-01 | 2024-05-17 | |
| Pilot Trial of E Cigarettes in Pts Diagnosed With Cancer of the Head, Neck, and Lung Best Practice, Nicotine Replacement, Quality-of-Life Assessment - Head and Neck Squamous Cell Carcinoma, Lung Non-Small Cell Carcinoma | Not applicable | Withdrawn | Ohio State University Comprehensive Cancer Center | 2024-01-01 | 2024-04-12 | |
| Quality of Life Intervention to Inform Patient Decision-Making in Early-Stage Lung Cancer Best Practice, Informational Intervention, Questionnaire Administration - Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Not applicable | Recruiting | Roswell Park Cancer Institute | 150 | 2023-12-21 | 2026-10-23 |
| Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography - Lung Carcinoma, Lung Non-Small Cell Carcinoma | Not applicable | Recruiting | Northwestern University | 70 | 2023-11-20 | 2026-05-29 |
| A Tool for Improving the Shared Decision-making Process in Patients With Non-small Cell Lung Cancer Best Practice, Communication Intervention, Electronic Health Record Review - Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Not applicable | Recruiting | Mayo Clinic | 100 | 2023-11-20 | 2026-08-20 |
| Subcutaneous Atezolizumab for the Treatment of Non-small Cell Lung Cancer Atezolizumab and Recombinant Human Hyaluronidase, Survey Administration - Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 2 | Active not recruiting | University of Southern California | 5 | 2022-12-07 | 2026-01-29 |
| The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer Pulmonary Artery-First Surgical Technique, Biospecimen Collection - Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Not applicable | Recruiting | Thomas Jefferson University | 100 | 2022-08-31 | 2026-01-23 |
| Papaverine in Combination With Chemoradiation for the Treatment of Stage II-III Non-small Cell Lung Cancer Carboplatin, Durvalumab, Paclitaxel - Locally Advanced Lung Non-Small Cell Carcinoma, Stage II Lung Cancer AJCC v8 | Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 28 | 2021-12-06 | 2026-06-30 |
| A Vaccine (CIMAvax-EGF) for the Prevention of Lung Cancer Development or Recurrence Quality-of-Life Assessment, Questionnaire Administration, Recombinant Human EGF-rP64K/Montanide ISA 51 Vaccine - Chronic Obstructive Pulmonary Disease, Lung Non-Small Cell Carcinoma | Early Phase 1 | Completed | Roswell Park Cancer Institute | 20 | 2021-11-22 | 2026-03-17 |
| Canakinumab for the Prevention of Lung Cancer, the Can-Prevent-Lung Trial Canakinumab, Quality-of-Life Assessment - Lung Carcinoma, Stage I Lung Cancer AJCC v8 | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 50 | 2021-07-20 | 2026-06-12 |
| Effects of Probiotics on the Gut Microbiome and Immune System in Operable Stage I-III Breast or Lung Cancer Biopsy, Biospecimen Collection, Probiotic - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Early Phase 1 | Completed | Mayo Clinic | 6 | 2021-07-01 | 2023-04-21 |
| Registrational Trial to Compare Effectiveness of Two Digital Software Medical Devices as Adjunctive Oncology Treatment Attune™, Cerena™ - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Terminated | Blue Note Therapeutics | 31 | 2021-05-15 | 2022-09-13 |
| Cognitive-Behavioral Stress Management Device for the Treatment of Anxiety and Depressive Symptoms in Patients With Stage I-III Breast or Lung Cancer Cognitive Behavior Therapy, Interview, Quality-of-Life Assessment - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8 | Not applicable | Terminated | Jonsson Comprehensive Cancer Center | 5 | 2021-04-08 | 2023-07-25 |
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Lung Neoplasms (47) · Carcinoma, Non-Small-Cell Lung (29) · Colorectal Neoplasms (3) · Pulmonary Disease, Chronic Obstructive (2) · Anxiety Disorders (1) · Colitis (1) · Depression (1) · Esophageal Neoplasms (1) · Liver Neoplasms (1) · Neoplasms (1) · Ovarian Neoplasms (1) · Pneumonia (1) · Sarcoma (1) · Squamous Cell Carcinoma of Head and Neck (1) · Urogenital Neoplasms (1)
Lung Diseases (47) · Neoplasms by Site (47) · Respiratory Tract Diseases (47) · Respiratory Tract Neoplasms (47) · Thoracic Neoplasms (47) · Neoplasms (46) · Bronchial Neoplasms (29) · Carcinoma, Bronchogenic (29) · Digestive System Diseases (5) · Gastrointestinal Diseases (5) · Colonic Diseases (4) · Digestive System Neoplasms (4) · Gastrointestinal Neoplasms (4) · Intestinal Diseases (4) · Intestinal Neoplasms (3)
Specimen Handling (16) · Magnetic Resonance Spectroscopy (9) · Radiation (7) · Disulfides (6) · Immunoglobulin G (6) · Practice Guidelines as Topic (6) · Radiotherapy (6) · Standard of Care (6) · Carboplatin (5) · Cisplatin (5) · Pemetrexed (5) · atezolizumab (5) · durvalumab (5) · 1,2-diaminocyclohexaneplatinum II citrate (4) · Contrast Media (4)
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Jianjun Zhang (2) · Kathrin Milbury (2) · Andrew D Ray (1) · Anne S Tsao (1) · Anurag K Singh (1) · Arya Amini (1) · Betty Ferrell (1) · Carlos E. Vargas, M.D. (1) · Daniel Morgensztern, MD (1) · Donald Sullivan (1) · Dwight H Owen (1) · Ellis Levine, MD (1) · Jacob M Sands (1) · Jennifer W Carlisle, MD (1) · Jeremey Brownstein, MD (1)
PMID 41747891, PMID 42335416, PMID 33415649, PMID 33878954, PMID 34036820, PMID 34663123, PMID 36006678, PMID 36040670, PMID 38351528, PMID 41529214, PMID 41911908, PMID 42183367, PMID 42532339, PMID 42548403, PMID 42702214, PMID 42830627
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