9 active not recruiting, 9 recruiting, 6 completed, 5 terminated. 12 Not applicable, 11 Phase 2, 4 Phase 1, 3 Phase 3, 1 Early Phase 1.
Follow Stage I Lung Cancer AJCC v8: new trials by email Literature Review of Stage I Lung Cancer AJCC v8 trials Research Report on Stage I Lung Cancer AJCC v8
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hotspot Stereotactic Ablative Radiotherapy Versus Traditional Stereotactic Ablative Radiotherapy for the Treatment of Early-Stage Non-Small Cell Lung Cancer Biospecimen Collection, Computed Tomography, Lymph Node Biopsy - Early Stage Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Phase 2 | Recruiting | Roswell Park Cancer Institute | 200 | 2026-09-01 | 2026-08-26 |
| New York Better Breathing Study Biospecimen Collection, Electronic Health Record Review, Medical Device Usage and Evaluation - Localized Lung Carcinoma, Stage I Lung Cancer AJCC v8 | Not applicable | Recruiting | Roswell Park Cancer Institute | 100 | 2026-04-20 | 2026-05-28 |
| Oral Iloprost for the Prevention of Lung Cancer In Former Smokers Biospecimen Collection, Bronchial Brush Biopsy, Bronchoscopy - Bronchial Epithelial Dysplasia, Chronic Obstructive Pulmonary Disease | Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2024-06-01 | 2024-05-17 | |
| Pilot Trial of E Cigarettes in Pts Diagnosed With Cancer of the Head, Neck, and Lung Best Practice, Nicotine Replacement, Quality-of-Life Assessment - Head and Neck Squamous Cell Carcinoma, Lung Non-Small Cell Carcinoma | Not applicable | Withdrawn | Ohio State University Comprehensive Cancer Center | 2024-01-01 | 2024-04-12 | |
| Quality of Life Intervention to Inform Patient Decision-Making in Early-Stage Lung Cancer Best Practice, Informational Intervention, Questionnaire Administration - Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Not applicable | Recruiting | Roswell Park Cancer Institute | 150 | 2023-12-21 | 2025-10-20 |
| Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Treatment of Primary or Metastatic Lung Tumors, RAD-AI Study Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography - Lung Carcinoma, Lung Non-Small Cell Carcinoma | Not applicable | Recruiting | Northwestern University | 70 | 2023-11-20 | 2026-05-29 |
| The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer Pulmonary Artery-First Surgical Technique, Biospecimen Collection - Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Not applicable | Recruiting | Thomas Jefferson University | 100 | 2022-08-31 | 2026-01-23 |
| Robotic Bronchoscopy With Cone CT and Indocyanine Green to Aid Removal of Lung Lesions in Patients With Stage I Non-small Cell Lung Cancer or Lung Metastases, REPLACING Study Computed Tomography, Indocyanine Green Solution, Therapeutic Bronchoscopy - Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Lung | Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2022-01-26 | 2024-10-23 | |
| Canakinumab for the Prevention of Lung Cancer, the Can-Prevent-Lung Trial Canakinumab, Quality-of-Life Assessment - Lung Carcinoma, Stage I Lung Cancer AJCC v8 | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 50 | 2021-07-20 | 2026-06-12 |
| Effects of Probiotics on the Gut Microbiome and Immune System in Operable Stage I-III Breast or Lung Cancer Biopsy, Biospecimen Collection, Probiotic - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Early Phase 1 | Completed | Mayo Clinic | 6 | 2021-07-01 | 2023-04-21 |
| Registrational Trial to Compare Effectiveness of Two Digital Software Medical Devices as Adjunctive Oncology Treatment Attune™, Cerena™ - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Terminated | Blue Note Therapeutics | 31 | 2021-05-15 | 2022-09-13 |
| Cognitive-Behavioral Stress Management Device for the Treatment of Anxiety and Depressive Symptoms in Patients With Stage I-III Breast or Lung Cancer Cognitive Behavior Therapy, Interview, Quality-of-Life Assessment - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8 | Not applicable | Terminated | Jonsson Comprehensive Cancer Center | 5 | 2021-04-08 | 2023-07-25 |
| Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer Best Practice, Biospecimen Collection, Endoscopic Procedure - Clinical Stage 0 Cutaneous Melanoma AJCC v8, Clinical Stage I Cutaneous Melanoma AJCC v8 | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 800 | 2021-02-21 | 2026-07-15 |
| Sapanisertib and Nivolumab for the Treatment of Stage I-IV Non-small Cell Lung Cancer in Patients Who Have Progressed on Prior PD-1/PD-L1 Inhibitor Therapy, I-OVERCOME Study Nivolumab, Sapanisertib - Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma | Phase 1 / Phase 2 | Withdrawn | M.D. Anderson Cancer Center | 2021-02-18 | 2022-05-27 | |
| NBTXR3 and Radiation Therapy for the Treatment of Inoperable Recurrent Non-small Cell Lung Cancer Hafnium Oxide-containing Nanoparticles NBTXR3, Radiation Therapy - Recurrent Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Phase 1 | Active not recruiting | M.D. Anderson Cancer Center | 34 | 2021-02-10 | 2026-08-19 |
| Sirolimus and Durvalumab for the Treatment of Stage I-IIIA Non-small Cell Lung Cancer Durvalumab, Sirolimus - Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Phase 1 | Terminated | Emory University | 3 | 2021-01-22 | 2024-08-22 |
| Testing the Addition of the Drug Atezolizumab to the Usual Radiation Treatment for Patients With Early Non-small Cell Lung Cancer Atezolizumab, Biospecimen Collection, Computed Tomography - Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Phase 3 | Active not recruiting | National Cancer Institute (NCI) | 417 | 2020-08-13 | 2026-10-06 |
| Decision Aid for the Improvement of Decision-Making in Patients With Non-small Cell Lung Cancer Best Practice, Informational Intervention, Questionnaire Administration - Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Not applicable | Active not recruiting | OHSU Knight Cancer Institute | 98 | 2020-08-07 | 2025-09-05 |
| Bintrafusp Alfa Before Surgery for the Treatment of Untreated Resectable Non-small Cell Lung Cancer Bintrafusp Alfa, Therapeutic Conventional Surgery - Resectable Lung Non-Small Cell Carcinoma, Stage I Lung Cancer AJCC v8 | Phase 2 | Terminated | M.D. Anderson Cancer Center | 2 | 2020-08-05 | 2022-07-28 |
| Family Caregivers in Underserved Populations Providing Complex Cancer Care Educational Intervention, Quality-of-Life Assessment, Questionnaire Administration - Malignant Female Reproductive System Neoplasm, Stage 0 Lung Cancer AJCC v8 | Not applicable | Completed | City of Hope Medical Center | 48 | 2020-07-15 | 2024-01-05 |
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Lung Neoplasms (34) · Carcinoma, Non-Small-Cell Lung (20) · Colorectal Neoplasms (3) · Adenocarcinoma of Lung (1) · Adenocarcinoma, Bronchiolo-Alveolar (1) · Anxiety Disorders (1) · Carcinoma, Neuroendocrine (1) · Colitis (1) · Depression (1) · Esophageal Neoplasms (1) · Liver Neoplasms (1) · Neoplasms (1) · Ovarian Neoplasms (1) · Pulmonary Disease, Chronic Obstructive (1) · Sarcoma (1)
Lung Diseases (34) · Neoplasms by Site (34) · Respiratory Tract Diseases (34) · Respiratory Tract Neoplasms (34) · Thoracic Neoplasms (34) · Neoplasms (33) · Bronchial Neoplasms (20) · Carcinoma, Bronchogenic (20) · Digestive System Diseases (5) · Gastrointestinal Diseases (5) · Colonic Diseases (4) · Digestive System Neoplasms (4) · Gastrointestinal Neoplasms (4) · Intestinal Diseases (4) · Intestinal Neoplasms (3)
Specimen Handling (8) · Practice Guidelines as Topic (5) · Standard of Care (5) · Radiosurgery (4) · Early Intervention, Educational (3) · Educational Status (3) · Magnetic Resonance Spectroscopy (3) · Methods (3) · 1,2-diaminocyclohexaneplatinum II citrate (2) · Cisplatin (2) · Disulfides (2) · Immunoglobulin G (2) · Nivolumab (2) · Platinum (2) · Radiation (2)
M.D. Anderson Cancer Center (11) · Roswell Park Cancer Institute (4) · City of Hope Medical Center (3) · National Cancer Institute (NCI) (3) · Mayo Clinic (2) · OHSU Knight Cancer Institute (2) · University of California, San Francisco (2) · Blue Note Therapeutics (1) · Emory University (1) · Jonsson Comprehensive Cancer Center (1) · Northwestern University (1) · Ohio State University Comprehensive Cancer Center (1) · SWOG Cancer Research Network (1) · Thomas Jefferson University (1)
United States (32) · Chile (1) · Colombia (1) · Japan (1) · Mexico (1)
Jianjun Zhang (2) · Kathrin Milbury (2) · Andrew D Ray (1) · Anurag K Singh (1) · Arya Amini (1) · Betty Ferrell (1) · Carlos E. Vargas, M.D. (1) · David W Rice (1) · Donald Sullivan (1) · Ellis Levine, MD (1) · Jennifer W Carlisle, MD (1) · Joe Y Chang (1) · Kristin A Higgins (1) · Marcelo V Negrao, MD (1) · Mark Farrugia (1)
PMID 33415649, PMID 34036820, PMID 34663123, PMID 36006678, PMID 36040670, PMID 37478883, PMID 38351528, PMID 41529214, PMID 42532339, PMID 42548403, PMID 42702214
P30CA033572 (2), P30CA060553 (2), K07CA215546 (1), P30CA016672 (1), P30CA138292 (1), P50CA217691 (1), R01CA222382 (1), R01CA249501 (1), R37CA231522 (1), U10CA180868 (1), U10CA180888 (1), UG1CA189974 (1), UG1CA242643 (1)