8 completed, 5 not yet recruiting, 4 recruiting, 4 unknown. 9 Not applicable, 3 Phase 2, 1 Phase 3, 1 Phase 4.
Follow Leptospirosis: new trials by email Literature Review of Leptospirosis trials Research Report on Leptospirosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| These Studies That Evaluated the Efficacy of Antibiotics for Leptospirosis Treatment. Doxycycline, Placebo - Leptospirosis, Chemoprophylaxis | Phase 4 | Not yet recruiting | Chulalongkorn University | 1000 | 2026-11-01 | 2026-10-08 |
| Assessment of the Risk of Zoonotic Infections in Prisons in French Guiana Q Fever, Leptospirosis | Not yet recruiting | Centre Hospitalier de Cayenne | 450 | 2026-10-01 | 2026-10-19 | |
| Ex Vivo Study of Leukocyte Responses in the Blood of Patients With Leptospirosis and ex Vivo Testing of a New Host-targeted Therapeutic Strategy to Restore Phagocytosis of Leptospira 24 ml blood sample at H0, 16 ml blood sample at H3 - Leptospirosis, Jarisch Herxheimer Reaction | Not yet recruiting | Institut Pasteur | 70 | 2026-07-01 | 2026-05-28 | |
| Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective Dengue, Chikungunya | Recruiting | Institut Pasteur du Cambodge | 10000 | 2025-12-18 | 2026-01-22 | |
| N-Acetylcysteine in Patients With Leptospirosis N-acetylcysteine, Placebo - Leptospirosis | Phase 2 | Completed | Dr Cipto Mangunkusumo General Hospital | 64 | 2025-08-30 | 2026-09-16 |
| Xpert® Tropical Fever Test on GeneXpert® Edge X System Xpert Tropical Fever test - Malaria Fever, Zika | Enrolling by invitation | Cepheid | 2500 | 2025-08-18 | 2026-04-09 | |
| Characterizing the Host Response to Leptospirosis for Better Diagnosis and Prognosis - NIHFI Blood sample, Urine Sample - Leptospirosis | Not applicable | Not yet recruiting | Institut Pasteur | 450 | 2025-06-01 | 2025-04-25 |
| Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases Peripheral venous blood sample - Leishmaniasis, Leptospirosis | Not applicable | Not yet recruiting | University Hospital, Montpellier | 183 | 2025-03-03 | 2025-03-05 |
| Preventive Strategies for Early and Late Complications of Leptospirosis Prophylactic Plasma Transfusion, Hemoperfusion, Extracorporeal Membrane Oxygenation - Leptospirosis | Phase 2 | Recruiting | National Kidney and Transplant Institute, Philippines | 678 | 2024-04-12 | 2026-04-13 |
| Chronic Post-leptospirosis Manifestations in Reunion Biological sampling and collection - Leptospirosis | Not applicable | Completed | Centre Hospitalier Universitaire de la Réunion | 198 | 2022-07-25 | 2026-08-06 |
| Seroprevalence of Leptospirosis in Val Müstair, Switzerland Blood sample collection, Data collection - Leptospirosis, Hepatitis E Virus Infection | Completed | University Hospital, Basel, Switzerland | 258 | 2022-03-03 | 2024-12-13 | |
| Study of the Incidence of Jarisch-Herxheimer Reaction in Leptospirosis Patients in New Caledonia Blood collection, Data collection - Leptospirosis, Jarisch Herxheimer Reaction | Not applicable | Unknown | Institut Pasteur | 900 | 2021-07-23 | 2022-08-17 |
| Study of the Innate Immune Response to the Acute Phase of Human Leptospirosis - IMMUNOLEPTO two additional blood samples specific to research - Leptospirosis | Not applicable | Completed | Centre Hospitalier Universitaire de la Réunion | 100 | 2021-01-06 | 2023-10-25 |
| Cohort of Hospitalized Patients Suspected of Leptospirosis Blood and urine sampling and blood banking - Leptospirosis | Not applicable | Active not recruiting | Institut National de la Santé Et de la Recherche Médicale, France | 200 | 2021-01-06 | 2026-08-20 |
| Leptospirosis Registry - LeptoScope Retrospective data collection of demographics, Retrospective data collection of underlying diseases, Retrospective data collection of duration of hospitalization - Leptospirosis | Recruiting | University of Cologne | 200 | 2020-03-04 | 2025-12-17 | |
| Leptospirosis Care Bundle Study Care Bundle - Leptospirosis | Not applicable | Recruiting | Chulalongkorn University | 300 | 2019-10-01 | 2026-10-02 |
| Seroprevalence Study to Evaluate the Persistence of Anti-leptospira Antibody in Subjects Vaccinated With Spirolept® Vaccine Leptospirosis | Completed | Imaxio | 145 | 2017-08-25 | 2018-05-08 | |
| Severe Leptospirosis in Non-tropical Areas Leptospirosis, Intensive Care Unit | Completed | Nantes University Hospital | 160 | 2017-05-07 | 2019-05-16 | |
| Immune Response After Leptospirosis Infection cohort - Leptospirosis | Unknown | Centre Hospitalier Universitaire de la Réunion | 175 | 2016-10-01 | 2016-09-13 | |
| Study of Decreasing Kinetics of the Leptospiremia During Antibiotic Treatment of Leptospirosis in Martinique Quantitative PCR performed at H0 , H24, H48 , H72, 7th day and 14th day - Leptospirosis | Unknown | University Hospital Center of Martinique | 50 | 2014-12-01 | 2022-03-09 |
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Malaria (4) · Brucellosis (3) · Chikungunya Fever (3) · Hepatitis E (3) · Q Fever (3) · Zika Virus Infection (3) · Dengue (2) · Encephalitis, Tick-Borne (2) · Inflammation (2) · Leishmaniasis (2) · Melioidosis (2) · Rickettsia Infections (2) · Tularemia (2) · Zoonoses (2)
Bacterial Infections (24) · Bacterial Infections and Mycoses (24) · Gram-Negative Bacterial Infections (24) · Spirochaetales Infections (24) · Infections (23) · Protozoan Infections (6) · Vector Borne Diseases (6) · Mosquito-Borne Diseases (5) · Parasitic Diseases (5) · RNA Virus Infections (5) · Virus Diseases (5) · Arbovirus Infections (4) · Digestive System Diseases (4) · Euglenozoa Infections (4) · Flaviviridae Infections (4)
Blood Specimen Collection (3) · Data Collection (2) · Acetylcysteine (1) · Blood Banking (1) · Cohort Studies (1) · Deamino Arginine Vasopressin (1) · Dexamethasone (1) · Doxycycline (1) · Educational Status (1) · Extracorporeal Membrane Oxygenation (1) · Hemoperfusion (1) · Patient Care Bundles (1) · Standard of Care (1) · Therapeutics (1)
Centre Hospitalier Universitaire de la Réunion (3) · Institut Pasteur (3) · Chulalongkorn University (2) · University Hospital Center of Martinique (2) · Centre Hospitalier de Cayenne (1) · Cepheid (1) · Dr Cipto Mangunkusumo General Hospital (1) · Imaxio (1) · Institut National de la Santé Et de la Recherche Médicale, France (1) · Institut Pasteur du Cambodge (1) · Kaohsiung Medical University Chung-Ho Memorial Hospital (1) · Mahidol University (1) · Nantes University Hospital (1) · National Kidney and Transplant Institute, Philippines (1) · University Hospital, Basel, Switzerland (1)
France (6) · Cambodia (2) · Reunion (2) · Thailand (2) · Democratic Republic of the Congo (1) · French Guiana (1) · Germany (1) · Indonesia (1) · Martinique (1) · Nepal (1) · New Caledonia (1) · Philippines (1) · Sudan (1) · Switzerland (1) · Taiwan (1)
Patrick Hochedez, MD (2) · Claude Flamand, Ph.D. (1) · Jean Reignier, MD, PhD (1) · Kanigar Niwattayakul, MD (1) · Maryse Beder, MD (1) · Michael Osthoff, PD Dr. med. (1) · Romina A Danguilan, MD (1)
PMID 22260085, PMID 22441648, PMID 27812090, PMID 30039781, PMID 30630398, PMID 32448209, PMID 35491421, PMID 35584144, PMID 35703611