39 completed, 17 recruiting, 11 unknown, 7 active not recruiting. 83 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 83 | Completed 39, Recruiting 17, Unknown 11, Active not recruiting 7, Not yet recruiting 4, Terminated 4, Withdrawn 1 |
Follow Spinal Dysraphism: new trials by email Literature Review of Spinal Dysraphism trials Research Report on Spinal Dysraphism
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Parenting Program for Young Children With Spina Bifida Positive Parenting Program - Spina Bifida | Not applicable | Not yet recruiting | Phoenix Children's Hospital | 30 | 2028-01-01 | 2026-11-04 |
| Motor Imagery-Supported Thoracic Expansion in Children With Spina Bifida Thoracic Expansion Exercises, Motor Imagery-Supported Thoracic Expansion Exercises - Spina Bifida | Not applicable | Not yet recruiting | Karabuk University | 30 | 2026-10-12 | 2026-09-29 |
| tSCS in Children With Spina Bifida Transcutaneous stimulator - Spina Bifida, Myelomeningocele | Not applicable | Recruiting | Bailey Petersen | 20 | 2026-09-30 | 2026-09-15 |
| Clinical Investigation to Validate the Safety and Performance of the ABLE Kids Device in Pediatric Patients With Neurological Gait Disorders in a Clinical Setting ABLE Kids - Gait Impairment, Cerebral Palsy (CP) | Not applicable | Recruiting | ABLE Human Motion S.L. | 15 | 2026-09-01 | 2026-09-08 |
| Enema Device for Children With Spina Bifida Use of the foley catheter assistive device - Spina Bifida, Fecal Incontinence | Not applicable | Recruiting | University of Colorado, Denver | 20 | 2026-08-11 | 2026-09-03 |
| Establishing the Preliminary Utility of a Novel Pediatric Manual Mobile Standing Wheelchair PedMMSWC Wheelchair User Testing, PedMMSWC Simulated Home, School, Community Environment - Spina Bifida | Not applicable | Recruiting | Optimal Mobility, Inc | 30 | 2026-06-18 | 2026-06-24 |
| Spina Bifida Healthcare Navigator Program Behavioral Treatment - Spina Bifida | Not applicable | Active not recruiting | University of Pittsburgh | 24 | 2026-04-15 | 2026-06-04 |
| Folic Acid Salt Study (FISFA Zambia) Fortified Iodized Salt with Folic Acid (FISFA) - Folate Deficiency, Neural Tube Defects | Not applicable | Recruiting | University of Alabama at Birmingham | 250 | 2026-04-10 | 2026-06-29 |
| Transcutaneous Tibial Nerve Stimulation (TTNS) Treatment in Spina Bifida Pediatric Patients With Neurogenic Bladder Transcutaneous Tibial Nerve Stimulation (TTNS) treatment - Spina Bifida | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 12 | 2025-11-18 | 2026-02-12 |
| Comparing Digitally and Traditionally Made Ankle Foot Orthoses Part A First Wear Period: Traditional AFO(s), Part A First Wear Period: Digital AFO(s), Part A Second Wear Period: Traditional AFO(s) - Flaccid Paresis, Spastic Paresis | Not applicable | Recruiting | Holland Bloorview Kids Rehabilitation Hospital | 50 | 2025-09-05 | 2025-11-20 |
| Effectiveness of Multimodal Therapy for Urinary Incontinence in Pediatric Spina Bifida Diet and Toileting Education, Pelvic Floor Physiotherapy, Abdominal Strengthening Program. - Myelomeningocele Spina Bifida, Spina Bifida, Open | Not applicable | Completed | Cairo University | 66 | 2025-09-01 | 2026-04-01 |
| Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida Transcutaneous stimulation - Myelomeningocele, Spina Bifida | Not applicable | Recruiting | Mayo Clinic | 30 | 2025-08-07 | 2026-11-06 |
| Autologous Human Umbilical Cord Tissue Patch for Postnatal Closure of Open Neural Tube Defects Autologous umbilical cord patch - Spina Bifida | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 15 | 2025-08-05 | 2026-09-24 |
| Fetoscopic Robotic Open Spina Bifida Treatment Fetoscopic robotic open spina bifida closure - Fetal Congenital Abnormalities, Fetoscopy | Not applicable | Not yet recruiting | Mount Sinai Hospital, Canada | 15 | 2025-07-01 | 2025-05-07 |
| Plyometric vs Resistance Training for Trunk Balance in Children With Spina Bifida upper extremity plyometric exercises, upper extremity resistance exercises - Spina Bifida, Balance Changes | Not applicable | Completed | Okan University | 28 | 2025-03-01 | 2025-08-15 |
| High Intensity Exercise and Improving Physical Activity Among People With Neurologic Dysfunction Participate in high intensity exercise of at least 20 minutes in 60 minutes session of RPE greater than 6. - Cerebral Palsy (CP), Stroke | Not applicable | Completed | University of Hartford | 15 | 2025-02-24 | 2025-11-03 |
| Effectiveness of Biofeedback Training in Children with Neurogenic Bladder and Bowel Disorder Wıth Spina Bifida Biofeedback exercise combined with breathing exercise, urotherapy educational group - Spina Bifida | Not applicable | Unknown | Hasan Kalyoncu University | 24 | 2024-10-21 | 2024-10-01 |
| The Study Aims to Improve the Accuracy of Detecting Spina Bifida During Early Ultrasound Scans. to Achieve This, an AI Model Has Been Developed to Provide Feedback About the Presence of Spina Bifida. a RCT Has Been Designed to Compare the Effectiveness of AI Feedback with No AI Feedback. Evaluation of XAI-assisted spina bifida diagnosis - Spina Bifida | Not applicable | Completed | Copenhagen Academy for Medical Education and Simulation | 38 | 2024-07-01 | 2024-12-04 |
| Psychosocial Teleassistance Programme for Adults With Spina Bifida Psychosocial teleassistance intervention - Spina Bifida, Self Esteem | Not applicable | Recruiting | University of Deusto | 35 | 2024-06-25 | 2025-12-10 |
| Evaluation of muLtimodal and Non-invasive SPINa Bifida Neurovessels During Prospective Follow-up Collection of a urine sample, Magnetic Resonance Imaging of the bladder - Spina Bifida | Not applicable | Recruiting | Rennes University Hospital | 50 | 2024-01-18 | 2025-12-22 |
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Cerebral Palsy (26) · Meningomyelocele (21) · Spinal Cord Injuries (18) · Neural Tube Defects (11) · Muscular Dystrophies (6) · Urinary Bladder, Neurogenic (6) · Stroke (5) · Arnold-Chiari Malformation (4) · Brain Injuries (4) · Multiple Sclerosis (4) · Musculoskeletal Diseases (4) · Spina Bifida Cystica (4) · Arthritis, Juvenile (3) · Bone Diseases, Metabolic (3)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (83) · Nervous System Malformations (82) · Congenital Abnormalities (81) · Nervous System Diseases (81) · Neural Tube Defects (72) · Central Nervous System Diseases (31) · Brain Diseases (28) · Brain Damage, Chronic (26) · Spinal Cord Diseases (18) · Trauma, Nervous System (18) · Wounds and Injuries (18) · Pathological Conditions, Signs and Symptoms (15) · Signs and Symptoms (13) · Musculoskeletal Diseases (11) · Neuromuscular Diseases (11)
Fetoscopy (4) · Health Resources (3) · Folic Acid (2) · Behavior Therapy (1) · Breathing Exercises (1) · Diet (1) · Electric Stimulation Therapy (1) · Equipment and Supplies (1) · Intermittent Urethral Catheterization (1) · Laminectomy (1) · Metformin (1) · Pamidronate (1) · Quality of Life (1) · Saline Solution (1) · Sodium Chloride (1)
McGill University (4) · University of Alabama at Birmingham (4) · Holland Bloorview Kids Rehabilitation Hospital (3) · Rennes University Hospital (3) · The University of Texas Health Science Center, Houston (3) · Assistance Publique - Hôpitaux de Paris (2) · Gillette Children's Specialty Healthcare (2) · Grand Valley State University (2) · National Institutes of Health Clinical Center (CC) (2) · University of Michigan (2) · University of Pittsburgh (2) · ABLE Human Motion S.L. (1) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Arkansas Colleges of Health Education (1) · Bailey Petersen (1)
United States (42) · Canada (11) · France (5) · Turkey (Türkiye) (4) · Spain (3) · Norway (2) · Bangladesh (1) · Belgium (1) · Denmark (1) · Egypt (1) · Indonesia (1) · Mexico (1) · Netherlands (1) · Pakistan (1) · South Korea (1)
Dana Anaby, PhD (4) · Ramen Chmait, MD (2) · Ramesha Papanna, MD, MPH (2) · Ruben Quintero, MD (2) · Thomas C Bulea, Ph.D. (2) · Adrien Winning (1) · Adrienne Kovacs, PhD,CPsych (1) · Ahmet Baschat, MD (1) · Amy McPherson, PhD (1) · Anastasia A Smith, DrPH (1) · Andi Saptono, Ph.D. (1) · Ariane Marelli, MD,MPH,FRCPC (1) · Bailey Petersen, PhD (1) · Bambang Parmanto, Ph.D. (1) · Brad E. Dicianno, M.D. (1)
PMID 21306277, PMID 16753432, PMID 20156062, PMID 21035565, PMID 21430869, PMID 22609118, PMID 25923030, PMID 26369371, PMID 26416930, PMID 26566108, PMID 27263997, PMID 27496687, PMID 29146566, PMID 29246577, PMID 30507586, PMID 30595963, PMID 30837255, PMID 31075056, PMID 31464189, PMID 31518302, PMID 31518315, PMID 31613408, PMID 31980545, PMID 32883297, PMID 33165214, PMID 33555337, PMID 33915336, PMID 34743701, PMID 35505001, PMID 36347777, PMID 36799340, PMID 37002023, PMID 38207160, PMID 38969555, PMID 38976710, PMID 39352737, PMID 39601932, PMID 41442093, PMID 41464320, PMID 42044869, PMID 950697
K23DK119368 (1), K23MD020447 (1), R01DK084034 (1), R01DK110749 (1), R01HD119340 (1), R44HD118822 (1), U01HD068541 (1)