117 completed, 42 unknown, 30 recruiting, 17 active not recruiting. 120 Not applicable, 11 Phase 2, 6 Phase 1, 6 Phase 3, 2 Phase 4.
Follow Neural Tube Defects: new trials by email Literature Review of Neural Tube Defects trials Research Report on Neural Tube Defects
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Motor Imagery-Supported Thoracic Expansion in Children With Spina Bifida Thoracic Expansion Exercises, Motor Imagery-Supported Thoracic Expansion Exercises - Spina Bifida | Not applicable | Not yet recruiting | Karabuk University | 30 | 2026-10-12 | 2026-09-29 |
| Abnormality of the Central Canal of the Spinal Cord in Syringomyelia in a Patient With a Basal Skull Malformation MRI - Chiari Malformation Type I, Syringomyelia | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 50 | 2026-09-30 | 2026-07-22 |
| tSCS in Children With Spina Bifida Transcutaneous stimulator - Spina Bifida, Myelomeningocele | Not applicable | Recruiting | Bailey Petersen | 20 | 2026-09-30 | 2026-09-15 |
| First-Trimester Screening of Open Neural Tube Defects Using Biometrics and Maternal Serum Markers Neural Tube Defects (NTDs) | Recruiting | University Hospital, Strasbourg, France | 100 | 2026-09-14 | 2026-10-07 | |
| Clinical Investigation to Validate the Safety and Performance of the ABLE Kids Device in Pediatric Patients With Neurological Gait Disorders in a Clinical Setting ABLE Kids - Gait Impairment, Cerebral Palsy (CP) | Not applicable | Recruiting | ABLE Human Motion S.L. | 15 | 2026-09-01 | 2026-09-08 |
| Health-related Quality of Life in Chiari Malformation Type 1 - A National Cross-Sectional Patient Survey Chiari Malformation Type I | Enrolling by invitation | Karolinska Institutet | 1004 | 2026-08-12 | 2026-09-14 | |
| Enema Device for Children With Spina Bifida Use of the foley catheter assistive device - Spina Bifida, Fecal Incontinence | Not applicable | Recruiting | University of Colorado, Denver | 20 | 2026-08-11 | 2026-09-03 |
| Coupled Gentamicin-Lactobacillus Rhamnosus in NLUTD Gentamicin, Lactobacillus Rhamnosus GG - Spinal Cord Injury, Neurogenic Bladder (NB) | Early Phase 1 | Not yet recruiting | Medstar Health Research Institute | 48 | 2026-08-01 | 2026-08-21 |
| Toward Ubiquitous Lower Limb Exoskeleton Use in Children and Young Adults Extension assist knee ankle foot orthosis (EA-KAFO) - Muscle Weakness, Problems Moving Their Arms and Legs | Recruiting | National Institutes of Health Clinical Center (CC) | 23 | 2026-06-23 | 2026-07-23 | |
| Establishing the Preliminary Utility of a Novel Pediatric Manual Mobile Standing Wheelchair PedMMSWC Wheelchair User Testing, PedMMSWC Simulated Home, School, Community Environment - Spina Bifida | Not applicable | Recruiting | Optimal Mobility, Inc | 30 | 2026-06-18 | 2026-06-24 |
| Spina Bifida Healthcare Navigator Program Behavioral Treatment - Spina Bifida | Not applicable | Active not recruiting | University of Pittsburgh | 24 | 2026-04-15 | 2026-06-04 |
| Folic Acid Salt Study (FISFA Zambia) Fortified Iodized Salt with Folic Acid (FISFA) - Folate Deficiency, Neural Tube Defects | Not applicable | Recruiting | University of Alabama at Birmingham | 250 | 2026-04-10 | 2026-06-29 |
| Bowel Continence Across the Lifespan in People With Spina Bifida Retrograde Enema, Antegrade Enema - Spina Bifida, Neurogenic Bowel | Recruiting | David Chu | 943 | 2026-04-01 | 2026-09-24 | |
| Efficacy of Intravesical Oxybutynin in Children With Neurogenic Bladder Dysfunction Oxybutynin Hydrochloride, Placebo - Spina Bifida | Phase 3 | Recruiting | Central Hospital, Nancy, France | 60 | 2026-01-15 | 2026-04-14 |
| Transcutaneous Tibial Nerve Stimulation (TTNS) Treatment in Spina Bifida Pediatric Patients With Neurogenic Bladder Transcutaneous Tibial Nerve Stimulation (TTNS) treatment - Spina Bifida | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 12 | 2025-11-18 | 2026-02-12 |
| Effectiveness of Electrical Pudendal Nerve Stimulation for Neurogenic Lower Urinary Tract Dysfunction in Pediatric Tethered Cord Syndrome Post-Surgery Electrical pudendal nerve stimulation, Conventional conservative treatment - Postoperative Neurogenic Lower Urinary Tract Dysfunction Secondary to Tethered Cord Syndrome | Not applicable | Not yet recruiting | Shanghai Institute of Acupuncture, Moxibustion and Meridian | 50 | 2025-11-01 | 2025-09-04 |
| Comparing Digitally and Traditionally Made Ankle Foot Orthoses Part A First Wear Period: Traditional AFO(s), Part A First Wear Period: Digital AFO(s), Part A Second Wear Period: Traditional AFO(s) - Flaccid Paresis, Spastic Paresis | Not applicable | Recruiting | Holland Bloorview Kids Rehabilitation Hospital | 50 | 2025-09-05 | 2025-11-20 |
| Effectiveness of Multimodal Therapy for Urinary Incontinence in Pediatric Spina Bifida Diet and Toileting Education, Pelvic Floor Physiotherapy, Abdominal Strengthening Program. - Myelomeningocele Spina Bifida, Spina Bifida, Open | Not applicable | Completed | Cairo University | 66 | 2025-09-01 | 2026-04-01 |
| Transcutaneous Spinal Stimulation for Children and Youth With Spina Bifida Transcutaneous stimulation - Myelomeningocele, Spina Bifida | Not applicable | Recruiting | Mayo Clinic | 30 | 2025-08-07 | 2025-10-14 |
| Autologous Human Umbilical Cord Tissue Patch for Postnatal Closure of Open Neural Tube Defects Autologous umbilical cord patch - Spina Bifida | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 15 | 2025-08-05 | 2026-09-24 |
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Spinal Dysraphism (139) · Meningomyelocele (58) · Cerebral Palsy (38) · Spinal Cord Injuries (35) · Arnold-Chiari Malformation (34) · Urinary Bladder, Neurogenic (22) · Syringomyelia (10) · Muscular Dystrophies (9) · Congenital Abnormalities (8) · Stroke (8) · Brain Injuries, Traumatic (7) · Anencephaly (6) · Multiple Sclerosis (6) · Spina Bifida Cystica (6)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (235) · Nervous System Malformations (234) · Nervous System Diseases (233) · Congenital Abnormalities (228) · Central Nervous System Diseases (68) · Pathological Conditions, Signs and Symptoms (63) · Signs and Symptoms (49) · Brain Diseases (46) · Spinal Cord Diseases (42) · Trauma, Nervous System (40) · Wounds and Injuries (40) · Neurologic Manifestations (39) · Brain Damage, Chronic (38) · Urogenital Diseases (37)
Fetoscopy (6) · Folic Acid (5) · Surveys and Questionnaires (5) · Blood Specimen Collection (3) · Health Resources (3) · Inositol (2) · Saline Solution (2) · Urinary Sphincter, Artificial (2) · Acetaminophen (1) · Acetazolamide (1) · Administration, Intravesical (1) · Amniocentesis (1) · Antilymphocyte Serum (1) · Behavior Therapy (1) · Bisphenols (1)
Assistance Publique - Hôpitaux de Paris (7) · Rennes University Hospital (7) · Assiut University (5) · Baylor College of Medicine (5) · University of Alabama at Birmingham (5) · Holland Bloorview Kids Rehabilitation Hospital (4) · McGill University (4) · The University of Texas Health Science Center, Houston (4) · Universitaire Ziekenhuizen KU Leuven (4) · University Hospital, Clermont-Ferrand (4) · University of Michigan (4) · Central Hospital, Nancy, France (3) · Duke University (3) · Hacettepe University (3) · Mayo Clinic (3)
United States (96) · France (32) · Turkey (Türkiye) (19) · Canada (15) · China (6) · Belgium (5) · Egypt (5) · Denmark (4) · Switzerland (4) · Netherlands (3) · South Korea (3) · Spain (3) · Brazil (2) · Germany (2) · Italy (2)
Dana Anaby, PhD (4) · Thomas C Bulea, Ph.D. (3) · Allison Ashley-Koch, PhD (2) · Christelle Destinval, MD (2) · Jogi Pattisapu, MD (2) · John D Heiss, M.D. (2) · Ramen Chmait, MD (2) · Ramesha Papanna, MD, MPH (2) · Robert S Adelstein, M.D. (2) · Ruben Quintero, MD (2) · Adrian Elmi-Terander, MD, PhD (1) · Adrienne Kovacs, PhD,CPsych (1) · Ahmad Elderwy, prof (1)
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K23DK119368 (1), R01DK084034 (1), R01DK110749 (1), R01HD039081 (1), R01HD119340 (1), R01HL147261 (1), R01NS039818 (1), R44HD118822 (1), U01HD068541 (1)