6 completed, 4 recruiting, 4 unknown, 3 withdrawn. 10 Phase 2, 5 Phase 1, 2 Not applicable, 1 Phase 4.
Follow Soft Tissue Sarcomas: new trials by email Literature Review of Soft Tissue Sarcomas trials Research Report on Soft Tissue Sarcomas
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors SHY-ONC6 - Advanced or Metastatic Solid Tumors, Triple Negative Breast Cancer (TNBC) | Phase 1 | Recruiting | SHY Therapeutics | 30 | 2026-06-24 | 2026-10-22 |
| A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas Pazopanib, Trabectedin, Ipilimumab - Soft Tissue Sarcomas | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 18 | 2026-06-12 | 2026-08-06 |
| Phase I Study of Safety and Feasibility of Transarterial Embolization of Incurable Hypervascular Pediatric Soft Tissue Sarcomas bland particles - Soft Tissue Sarcomas | Not applicable | Withdrawn | University of Alabama at Birmingham | 2026-02-01 | 2026-06-16 | |
| IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS) Tislelizumab+liposomal doxorubicin+ifosfamide - Soft Tissue Sarcomas, Angiosarcoma | Phase 2 | Recruiting | Fudan University | 45 | 2025-02-25 | 2026-01-08 |
| The Total Neoadjuvant Therapy for Soft Tissue Sarcoma of the Extremities Hypofractionated Radiotherapy, 3 cycles of AI - Soft Tissue Sarcomas | Phase 2 | Unknown | Fujian Medical University Union Hospital | 51 | 2024-05-01 | 2024-09-19 |
| Gene Signatures Searching of Sensitivity/Resistance to Neoadjuvant Radiotherapy in Patients With Resectable STS pre-operative radiation, Standard surgery after rpreoprative radiation - Soft Tissue Sarcomas | Unknown | Centre Leon Berard | 300 | 2022-11-23 | 2023-02-22 | |
| Short Course Of Preoperative Radiotherapy in Head and Neck-, Trunk- and Extremity Soft Tissue Sarcomas pre-operative radiotherapy - Soft Tissue Sarcomas | Not applicable | Active not recruiting | The Netherlands Cancer Institute | 168 | 2021-06-25 | 2026-09-17 |
| Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas Ultra-Hypo-fractionation Radiotherapy, Resection, Questionnaire Administration - Soft Tissue Sarcomas | Phase 2 | Recruiting | Vanderbilt-Ingram Cancer Center | 40 | 2021-03-02 | 2025-03-28 |
| Study of Anlotinib Hydrochloride and Toripalimab in Subjects With Unresectable or Metastatic Undifferentiated Pleomorphic Sarcoma Anlotinib, Toripalimab, Blood Draw - Soft Tissue Sarcomas, Undifferentiated Pleomorphic Sarcoma | Phase 2 | Unknown | Di Wu | 25 | 2019-07-19 | 2019-07-10 |
| Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule Anlotinib Hydrochloride - Soft Tissue Sarcomas | Phase 4 | Completed | Henan Cancer Hospital | 70 | 2019-06-26 | 2022-03-16 |
| Study of Nivolumab With or Without Pazopanib in Metastatic or Unresectable Soft Tissue Sarcomas Nivolumab, Pazopanib - Soft Tissue Sarcomas | Phase 2 | Withdrawn | NYU Langone Health | 2017-08-01 | 2017-08-22 | |
| A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric Refractory Solid Tumors Magnetic resonance high intensity focused ultrasound, Lyso-thermosensitive liposomal doxorubicin - Pediatric Cancer, Solid Tumors | Phase 1 | Terminated | AeRang Kim | 2 | 2016-10-01 | 2023-08-29 |
| Axitinib and Pembrolizumab in Subjects With Advanced Alveolar Soft Part Sarcoma and Other Soft Tissue Sarcomas Axitinib, Pembrolizumab - Alveolar Soft Part Sarcoma, Soft Tissue Sarcomas | Phase 2 | Completed | Jonathan Trent, MD, PhD | 33 | 2016-04-19 | 2024-07-12 |
| Clinical Study of Concurrent Pazopanib and Radiotherapy for Non-metastatic Sarcoma Patients external beam radiotherapy, pazopanib - Sarcoma, Soft Tissue Sarcomas | Phase 2 | Terminated | The Netherlands Cancer Institute | 25 | 2016-03-17 | 2019-06-27 |
| RAD001 in Advanced Sarcoma RAD001 - Soft Tissue Sarcomas, Bone Sarcomas | Phase 2 | Completed | Asan Medical Center | 41 | 2010-04-01 | 2013-04-12 |
| Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas Chemoradiotherapy Temozolomide, Proton therapy, Proton Chemoradiotherapy followed by surgery - Soft Tissue Sarcomas | Phase 2 | Withdrawn | University of Florida | 2009-02-01 | 2017-02-10 | |
| 11C-Acetate PET/CT Non-FDG-Avid Tumors Soft Tissue Sarcomas, Thyroid Cancer | Unknown | Tel-Aviv Sourasky Medical Center | 100 | 2008-05-01 | 2008-06-02 | |
| Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer. PSMA/PRAME - Ovarian, Melanoma | Phase 1 | Completed | Mannkind Corporation | 12 | 2007-02-01 | 2010-08-03 |
| The Biological Activity of Cediranib (AZD2171) in Gastro-Intestinal Stromal Tumours(GIST). AZD2171 - Gastrointestinal Stromal Tumors, Soft Tissue Sarcomas | Phase 2 | Completed | AstraZeneca | 35 | 2006-09-01 | 2012-07-16 |
| Safety Study of IPI-504 in Patients With Gastrointestinal Stromal Tumors (GIST) or Soft Tissue Sarcomas (STS) IPI-504 - Gastrointestinal Stromal Tumors, Soft Tissue Sarcomas | Phase 1 | Completed | Infinity Pharmaceuticals, Inc. | 63 | 2005-12-01 | 2011-01-06 |
Sarcoma (20) · Bone Neoplasms (2) · Carcinoma, Hepatocellular (2) · Gastrointestinal Stromal Tumors (2) · Mesothelioma (2) · Neoplasms (2) · Stomach Neoplasms (2) · Thyroid Neoplasms (2) · Anus Neoplasms (1) · Biliary Tract Neoplasms (1) · Breast Neoplasms (1) · Carcinoma, Lobular (1) · Carcinoma, Neuroendocrine (1) · Carcinoma, Non-Small-Cell Lung (1) · Colonic Neoplasms (1)
Neoplasms by Histologic Type (20) · Neoplasms, Connective and Soft Tissue (20) · Neoplasms (18) · Digestive System Diseases (6) · Digestive System Neoplasms (6) · Neoplasms by Site (5) · Neoplasms, Connective Tissue (5) · Gastrointestinal Diseases (4) · Gastrointestinal Neoplasms (4) · Neoplasms, Glandular and Epithelial (4) · Neoplasms, Nerve Tissue (4) · Adenocarcinoma (3) · Breast Diseases (3) · Carcinoma (3) · Liver Diseases (3)
Radiotherapy (3) · pazopanib (3) · Nivolumab (2) · Axitinib (1) · Biopsy, Needle (1) · Blood Specimen Collection (1) · Everolimus (1) · Ipilimumab (1) · Phlebotomy (1) · Proton Therapy (1) · Radiation Dose Hypofractionation (1) · Temozolomide (1) · Trabectedin (1) · anlotinib (1) · cediranib (1)
The Netherlands Cancer Institute (2) · AeRang Kim (1) · Asan Medical Center (1) · AstraZeneca (1) · Centre Leon Berard (1) · Di Wu (1) · Fudan University (1) · Fujian Medical University Union Hospital (1) · Henan Cancer Hospital (1) · Infinity Pharmaceuticals, Inc. (1) · Jonathan Trent, MD, PhD (1) · M.D. Anderson Cancer Center (1) · Mannkind Corporation (1) · NYU Langone Health (1) · SHY Therapeutics (1)
United States (8) · China (4) · Netherlands (2) · United Kingdom (2) · Canada (1) · France (1) · Israel (1) · South Korea (1)
Rick Haas, MD, PhD (2) · AeRang Kim, MD, PhD (1) · Brandon D Brown, MD (1) · Daniel J Indelicato, MD (1) · Einat Even-Sapir, MD, PhD (1) · Eric Shinohara, MD (1) · George D Demetri, MD, PhD (1) · Jane Robertson, MD (1) · Jin-Hee Ahn, MD, PhD (1) · Jonathan C Trent, MD (1) · Junaid Raja, MD, MSPH, FACP (1) · Luca Paoluzzi (1) · Peng Zhang, Deputy director (1) · Yong Yang, Doctor (1)