249 completed, 90 terminated, 75 recruiting, 68 unknown. 252 Phase 2, 231 Phase 1, 45 Not applicable, 26 Phase 3, 7 Early Phase 1.
Follow Mesothelioma: new trials by email Literature Review of Mesothelioma trials Research Report on Mesothelioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase 3 Trial in Advanced Epithelioid Mesothelioma VT3989, gemcitabine, Vinorelbine - Pleural Mesothelioma, Mesothelioma | Phase 3 | Not yet recruiting | Vivace Therapeutics, Inc | 350 | 2026-12-01 | 2026-09-17 |
| Efficacy and Safety of Ivonescimab Plus Pemetrexed and Platinum-Based Chemotherapy in Advanced Malignant Pleural Mesothelioma Ivonescimab Combined With Chemotherapy - Malignant Pleural Mesothelioma, Advanced | Phase 1 / Phase 2 | Not yet recruiting | Ruijin Hospital | 78 | 2026-11-01 | 2026-10-21 |
| TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid Tumors TLN-499, Venetoclax - Small Cell Lung Cancer ( SCLC ), Neuroendocrine Cancer | Phase 1 | Recruiting | Treeline Biosciences, Inc. | 120 | 2026-08-05 | 2026-10-01 |
| FAPI PET Imaging - An Exploratory Study [18F]FAPI-74 PET/CT - Thyroid Pathology, Head and Neck Cancer (H&N) | Phase 1 / Phase 2 | Not yet recruiting | Martin Huellner | 770 | 2026-08-01 | 2026-07-15 |
| A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors SHY-ONC6 - Advanced or Metastatic Solid Tumors, Triple Negative Breast Cancer (TNBC) | Phase 1 | Recruiting | SHY Therapeutics | 30 | 2026-06-24 | 2026-10-22 |
| Evaluation of Skin Tests in Biotherapy Allergies Drug skin tests (investigating hypersensitivity to a biotherapy) - Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck, Melanoma Neoplasms | Not applicable | Recruiting | University Hospital, Angers | 70 | 2026-06-17 | 2026-06-18 |
| Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | David Bartlett, MD | 10 | 2026-06-03 | 2026-08-04 |
| SELECTmeso A Trial for Patients With Relapsed Malignant Mesothelioma SELECTmeso1 A Trial of BMS-986504 in Patients With MTAP-deficient Relapsed Mesothelioma BMS-986504 - Mesothelioma | Phase 2 | Not yet recruiting | University of Southampton | 30 | 2026-05-11 | 2026-05-22 |
| Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 (IL-2) - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 10 | 2026-05-01 | 2026-04-07 |
| Trial Assessing Fianlimab Plus Cemiplimab Plus Chemotherapy or Cemiplimab Plus Chemotherapy in Patients With Pleural Mesothelioma Cemiplimab, Fianlimab, Pemetrexed (Alimta) - Pleural Mesotheliomas | Phase 2 | Recruiting | Intergroupe Francophone de Cancerologie Thoracique | 126 | 2026-04-02 | 2026-08-11 |
| Iparomlimab Plus Tovorilimab Combined With Bevacizumab and Chemotherapy as First-Line Treatment for Advanced Mesothelioma Iparomlimab and Tuvoraleimab injection+Bevacizumab+Pemetrexed+Cisplatin - Mesothelioma | Phase 2 | Not yet recruiting | Fudan University | 37 | 2026-04-01 | 2026-04-07 |
| Comprehensive Oncogenomic Mapping and Exploration in Thoracic and Head & Neck Oncology Blood and Tissue Collection - Small Cell Lung Cancer, Head and Neck Cancer | Not yet recruiting | University of Kansas Medical Center | 110 | 2026-04-01 | 2026-04-24 | |
| A 2-part Phase 1/2 Open-label Trial on ODM-212 ODM-212, Ipilimumab and nivolumab, Gemcitabine and nab-paclitaxel - Mesothelioma, Pancreatic Cancer | Phase 1 / Phase 2 | Recruiting | Orion Corporation, Orion Pharma | 229 | 2026-03-27 | 2026-10-22 |
| Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma alrizomadlin - Mesothelioma, Malignant Mesothelioma (MM) | Phase 2 | Withdrawn | National Cancer Institute (NCI) | 2026-03-16 | 2026-03-17 | |
| An Open-label, Single-arm Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Profile, and Preliminary Efficacy of KT032 Cell Injection in Patients With Mesothelin-positive Advanced Solid Tumors. KT032(anti-MSLN chimeric antigen receptor autologous T cell injection) - Ovarian Cancer, Mesothelioma | Early Phase 1 | Not yet recruiting | Weijia Fang, MD | 24 | 2026-03-15 | 2026-02-19 |
| A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors IDE892, IDE397 - NSCLC Adenocarcinoma, Gastroesophageal Cancer (GC) | Phase 1 | Recruiting | IDEAYA Biosciences | 260 | 2026-03-04 | 2026-09-28 |
| Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal Mesothelioma EB-MF-CAR-NK-01, Fludarabine, Cyclophosphamide - Malignant Pleural Mesotheliomas | Phase 1 / Phase 2 | Recruiting | Beijing Biotech | 36 | 2026-03-02 | 2026-04-06 |
| Study of TYK-01054 Capsules in Patients With Advanced Solid Tumors TYK-01054 - Solid Tumor Malignancies, Malignant Mesothelioma (MM) | Phase 1 / Phase 2 | Not yet recruiting | TYK Medicines, Inc | 219 | 2026-01-01 | 2025-12-22 |
| Partial Pleurectomy (Surgery) for Unresectable Pleural Mesothelioma Partial Pleurectomy - Mesothelioma, Mesothelioma; Lung | Not applicable | Recruiting | University of Chicago | 30 | 2025-12-02 | 2026-02-17 |
| 18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection [18F]FAPI-74, [18F]FDG - Sarcoma, Small Cell Lung Cancer or Extrapulmonary Neuroendocrine Cancer (EP-NEC) | Phase 2 | Recruiting | National Cancer Institute (NCI) | 320 | 2025-09-09 | 2026-05-19 |
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Mesothelioma, Malignant (329) · Carcinoma, Non-Small-Cell Lung (125) · Lung Neoplasms (75) · Ovarian Neoplasms (71) · Stomach Neoplasms (61) · Melanoma (59) · Pancreatic Neoplasms (59) · Carcinoma, Renal Cell (55) · Esophageal Neoplasms (54) · Colorectal Neoplasms (52) · Small Cell Lung Carcinoma (51) · Breast Neoplasms (48) · Uterine Cervical Neoplasms (48) · Neoplasms (47)
Neoplasms, Glandular and Epithelial (564) · Adenoma (563) · Neoplasms by Histologic Type (563) · Neoplasms, Mesothelial (563) · Neoplasms (517) · Neoplasms by Site (480) · Thoracic Neoplasms (447) · Respiratory Tract Diseases (446) · Respiratory Tract Neoplasms (445) · Lung Diseases (439) · Lung Neoplasms (366) · Pleural Neoplasms (333) · Digestive System Diseases (146) · Digestive System Neoplasms (144)
Cisplatin (78) · Pemetrexed (73) · pembrolizumab (39) · Nivolumab (27) · Carboplatin (25) · Gemcitabine (21) · Cyclophosphamide (18) · Ipilimumab (16) · Drug Therapy (12) · Radiotherapy (10) · atezolizumab (10) · durvalumab (10) · Bevacizumab (9) · Vinorelbine (9) · Doxorubicin (8)
National Cancer Institute (NCI) (51) · Memorial Sloan Kettering Cancer Center (19) · M.D. Anderson Cancer Center (11) · Dana-Farber Cancer Institute (8) · University of Chicago (8) · Alliance for Clinical Trials in Oncology (7) · Eli Lilly and Company (7) · European Organisation for Research and Treatment of Cancer - EORTC (7) · Mayo Clinic (7) · Novartis Pharmaceuticals (7) · Ain Shams University (6) · University Health Network, Toronto (6) · Abramson Cancer Center at Penn Medicine (5) · Bayer (5) · Incyte Corporation (5)
United States (315) · United Kingdom (68) · Italy (64) · France (53) · Canada (39) · Netherlands (34) · Spain (34) · Australia (32) · Belgium (31) · China (27) · Germany (25) · Switzerland (21) · Japan (20) · Poland (18) · Egypt (14)
David S Schrump, M.D. (12) · Raffit Hassan, M.D. (12) · Armando Santoro, MD (5) · Dean Fennell (4) · Hedy Kindler (4) · Anne S Tsao (3) · Anne S. Tsao, MD (3) · Antonio Lambiase, MD (3) · David J. Sugarbaker, MD (3) · Dennis Wigle, MD, PhD (3)
PMID 33358660, PMID 31576173, PMID 34499875, PMID 35048355, PMID 36053283, PMID 36104949, PMID 37279993, PMID 42580817, PMID 10500494, PMID 11165136, PMID 11487589, PMID 12565988, PMID 15084390, PMID 15764728, PMID 16192580, PMID 16446322, PMID 16554548, PMID 17295916, PMID 17395581, PMID 17429100, PMID 18006112, PMID 18089874, PMID 18224661, PMID 18486741, PMID 18797818, PMID 19192962, PMID 19360120, PMID 19451433, PMID 19556318, PMID 19564349, PMID 19652065, PMID 19671873, PMID 20068553, PMID 20154079, PMID 20167848, PMID 20400682, PMID 20406925, PMID 20525721, PMID 20530048, PMID 20549206, PMID 20615924, PMID 20647340, PMID 21135147, PMID 21149657, PMID 21262916, PMID 21467219, PMID 21632857, PMID 21642245, PMID 21684151, PMID 21874000
2016 (8), U10CA031946 (8), 2019 (7), 2023 (6), 2015 (5), U10CA032102 (5), 2017 (4), P30CA014599 (3), 2008 (2), 2009 (2), N01CM17102 (2), P01CA066726 (2), P30CA016672 (2), P30CA022453 (2), P30CA043703 (2)