11 completed, 9 recruiting, 5 not yet recruiting, 2 active not recruiting. 9 Phase 2, 6 Not applicable, 5 Phase 3, 4 Phase 1, 2 Phase 4.
Follow Sjogren Syndrome: new trials by email Literature Review of Sjogren Syndrome trials Research Report on Sjogren Syndrome
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of Topical Infliximab in Autoimmune Dry Eye Disease Infliximab 0.1%, Loteprednol - Sjogren Syndrome, Sjogren Syndrome With Keratoconjunctivitis | Phase 2 | Not yet recruiting | Instituto de Oftalmología Fundación Conde de Valenciana | 38 | 2026-12-01 | 2026-06-26 |
| Exosome and Mesenchymal Stem Cell Treatment for Salivary Gland Dysfunction in Primary Sjögren Syndrome exosomes derived from human umbilical cord mesenchymal stem cells, Mesenchymal Stem Cells (MSC), Placebo - Sjogren Syndrome, Xerostomia | Phase 2 | Not yet recruiting | Banu Erkal | 30 | 2026-12-01 | 2026-09-24 |
| Safety and Efficacy of Universal CAR-T Cells (UWD-CD19) Combined With Immunosuppressants in the Treatment of Refractory Autoimmune Diseases anti-CD19 CAR-T cells - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Not yet recruiting | Peking University Third Hospital | 9 | 2026-11-01 | 2026-09-23 |
| Effectiveness of an Oral Exercise Program for Xerostomia in Patients With Sjögren Disease Oral exercise - Sjogren Syndrome | Not applicable | Not yet recruiting | Nazli Elif Nacar | 56 | 2026-10-26 | 2026-10-08 |
| Fatigue in Sjögren's Syndrome: 3 Therapeutic Strategies Acupuncture (ACU), Transcutaneous Vagus Nerve Stimulation (tVNS), APA (adapted physical activity ) - Sjogren Syndrome | Not applicable | Recruiting | Centre Hospitalier Universitaire de Saint Etienne | 174 | 2026-03-24 | 2026-09-30 |
| TREATMENT OF VAGINAL DRYNESS IN SJÖGREN'S DISEASE WITH CO2-LASER VERSUS TOPICAL PROMESTRIENE Fractional CO2 laser (vaginal), Promestriene Vaginal - Sjogren Syndrome, Sjogren Disease | Phase 4 | Recruiting | University of Sao Paulo General Hospital | 60 | 2026-02-27 | 2026-03-03 |
| Clinical Study of BCT301 Cell Injection Therapy for Refractory Autoimmune Diseases BCT301 - System Lupus Erythematosus, Systemic Sclerosis (SSc) | Early Phase 1 | Recruiting | Peking University Third Hospital | 10 | 2025-12-11 | 2026-09-23 |
| AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases. Allogeneic NK Cells - Refractory Rheumatoid Arthritis (RA), Idiopathic Inflammatory Myopathies (IIMs) | Phase 2 | Recruiting | Artiva Biotherapeutics, Inc. | 90 | 2025-07-09 | 2026-07-31 |
| Safety and Efficacy of Universal CD19-targeting CAR-γδT Cells in Refractory Autoimmune Diseases anti-CD19 CAR T cell therapy - Systemic Lupus Erthematosus, Systemic Sclerosis (SSc) | Phase 1 / Phase 2 | Recruiting | Peking University Third Hospital | 9 | 2025-07-01 | 2026-09-22 |
| Photodynamic Treatment as Part of Oral Healthcare on Persons With Sjögren's Syndrome Lumoral treatment - Sjogren Syndrome, Xerostomia | Not applicable | Active not recruiting | Koite Health Oy | 16 | 2025-05-24 | 2025-08-08 |
| Temporomandibular Joint Dysfunction in Sjögren's Syndrome Temporomandibular Joint Function - Sjogren Syndrome | Completed | Pamukkale University | 27 | 2025-05-15 | 2025-11-25 | |
| "Validity and Reliability of Pelvic Floor Distress Inventory-20 in Primary Sjögren's Syndrome" the validity and reliability study - Sjogren Syndrome | Completed | Pamukkale University | 10 | 2025-03-28 | 2025-11-25 | |
| "Core Stabilization Strenght and Pelvic Floor Functions in Primary Sjogren's" Core Muscle testing and patient reported outcome measures - Sjogren Syndrome, Healthy Volunteers | Enrolling by invitation | Pamukkale University | 10 | 2025-02-05 | 2025-03-17 | |
| BCMA-CD19 CAR-T Therapy for Refractory Autoimmune Diseases BCMA-CD19 CAR-T therapy - Systemic Lupus Erythematosus, Inflammatory Myopathy | Phase 2 | Recruiting | Peking University People's Hospital | 50 | 2024-12-26 | 2025-04-02 |
| Ultrasonic COmparison of Salivary Glands in Autoimmune Diseases (COUGAR) Sjogren Syndrome, Dry Syndrome | Not yet recruiting | University Hospital, Brest | 501 | 2024-12-01 | 2024-11-08 | |
| Intra-Nasal Mechanical Stimulation (INMEST) as a Potential Treatment Method for Sjogren's Syndrome (SS) Intra nasal mechanical stimulation treatment (INMEST), Sham (No Treatment) - Sjogren Syndrome | Not applicable | Completed | Abilion Medical Systems AB | 26 | 2024-11-05 | 2025-09-03 |
| Rare AutoImmune SElf-management Programme Development Non-interventional study - Systemic Lupus Erthematosus, Systemic Vasculitis | Recruiting | University of the West of England | 360 | 2024-10-01 | 2024-10-15 | |
| Comparing Efficacy of Autologous Serum Eye Drops With and Without Insulin in Autoimmune Dry Eye. recombinant human insulin, Autologous serum - Dry Eye, Sjogren Syndrome | Phase 3 | Completed | Instituto de Oftalmología Fundación Conde de Valenciana | 25 | 2024-02-01 | 2026-08-27 |
| Interferon Signature in Anti-CTLA-4 and Anti-PD-1/PD-L1-Treated Cancer Patients Compared With Systemic Autoimmune Disease Patients Immune Checkpoint Inhibitors - Immune-Related Adverse Events, Lupus Erythematosus, Systemic | Recruiting | Hospital Universitario Araba | 300 | 2024-01-08 | 2025-12-03 | |
| Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome VAY736, Placebo - Sjogren Syndrome | Phase 3 | Active not recruiting | Novartis Pharmaceuticals | 506 | 2022-08-04 | 2026-06-17 |
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Sjogren's Syndrome (32) · Scleroderma, Systemic (8) · Dry Eye Syndromes (6) · Myositis (6) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (5) · Lupus Erythematosus, Systemic (5) · Xerostomia (5) · Antiphospholipid Syndrome (4) · Arthritis, Rheumatoid (4) · Scleroderma, Diffuse (3) · Arthritis, Psoriatic (2) · Autoimmune Diseases (1) · Behcet Syndrome (1) · Bronchiolitis Obliterans Syndrome (1) · Colitis, Ulcerative (1)
Arthritis (32) · Connective Tissue Diseases (32) · Eye Diseases (32) · Immune System Diseases (32) · Joint Diseases (32) · Lacrimal Apparatus Diseases (32) · Mouth Diseases (32) · Musculoskeletal Diseases (32) · Rheumatic Diseases (32) · Salivary Gland Diseases (32) · Skin and Connective Tissue Diseases (32) · Stomatognathic Diseases (32) · Autoimmune Diseases (31) · Arthritis, Rheumatoid (28) · Xerostomia (27)
ianalumab (3) · Tacrolimus (2) · Acupuncture Therapy (1) · Aspartame (1) · CTLA-4 Antigen (1) · Cyclosporins (1) · Exercise (1) · Glutamyl Aminopeptidase (1) · Immune Checkpoint Inhibitors (1) · Infliximab (1) · Ipilimumab (1) · Loteprednol Etabonate (1) · Nivolumab (1) · Olive Oil (1) · Patient Reported Outcome Measures (1)
Novartis Pharmaceuticals (4) · Pamukkale University (3) · Peking University Third Hospital (3) · Instituto de Oftalmología Fundación Conde de Valenciana (2) · University of Sao Paulo General Hospital (2) · Abilion Medical Systems AB (1) · Artiva Biotherapeutics, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Augusta University (1) · Banu Erkal (1) · Centre Hospitalier Universitaire de Saint Etienne (1) · Hospital Universitario Araba (1) · Koite Health Oy (1) · National Cancer Institute (NCI) (1) · National Taiwan University Hospital (1)
France (7) · China (6) · Brazil (5) · Spain (5) · Turkey (Türkiye) (5) · United States (5) · Germany (4) · Mexico (4) · Poland (4) · Italy (3) · Taiwan (3) · Bulgaria (2) · Canada (2) · Chile (2) · Hungary (2)
Banu Erkal, Resident (1) · Enrique Graue-Hernandez, MD, MSc (1) · Gaafar Ragab (1) · Hsiao-Sang Chu, MD, MS (1) · Hussein A Tawbi (1) · Joanna Robson (1) · Michael Saddekni, M.D., PgDip, BCMAS (1) · Nathalie Costedoat-Chalumeau, PhD (1) · Omar El Zawahry (1) · Rehab Shamma (1) · Saila Pakarinen, DDS (1) · Scott S De Rossi, DMD (1)
PMID 16142864, PMID 16987829, PMID 17471524, PMID 20360188, PMID 21109517, PMID 25240992, PMID 25479696, PMID 25956572, PMID 29970389, PMID 33530719, PMID 34133081, PMID 35015828, PMID 35470301, PMID 38261392, PMID 38837707, PMID 39702994, PMID 40546749, PMID 40747756, PMID 40787733, PMID 41538013, PMID 41726564, PMID 42049394
2023 (1), UM1CA186688 (1)