14 unknown. 14 Phase 2, 2 Phase 1, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 14 | Unknown 14 |
| Phase 1 | 2 | Unknown 2 |
| Phase 3 | 2 | Unknown 2 |
Follow Sickle Cell Disease: new trials by email Literature Review of Sickle Cell Disease trials Research Report on Sickle Cell Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lidocaine Intravenous in the Emergency Department For Sickle Cell Crisis Lidocaine Iv, Placebo - Sickle Cell Disease, Sickle Cell Crisis | Phase 2 | Unknown | Community Medical Center, Toms River, NJ | 100 | 2024-01-01 | 2023-08-29 |
| Hemolysis Related Complications in SCD. A Phase II Study With Voxelotor Voxelotor 1500 mg oral per day (GBT440) for 48 weeks in patients with sickle-cell disease - Sickle Cell Disease | Phase 2 | Unknown | Assistance Publique - Hôpitaux de Paris | 30 | 2023-03-22 | 2023-09-21 |
| TAPS2 Transfusion Antenatally in Pregnant Women With SCD Serial prophylactic exchange blood transfusion (SPEBT). - Sickle Cell Disease, Pregnancy, High Risk | Phase 2 | Unknown | Guy's and St Thomas' NHS Foundation Trust | 50 | 2019-05-02 | 2019-08-02 |
| Outcomes Mandate National Integration With Cannabis as Medicine Cannabis, Medical, RYAH-Medtech Inhaler - Chronic Pain, Chronic Pain Syndrome | Phase 2 | Unknown | OMNI Medical Services, LLC | 200000 | 2018-12-01 | 2022-06-02 |
| Rifaximin to Modify the Disease Course in Sickle Cell Disease Rifaximin - Sickle Cell Disease, Antibiotics | Phase 2 | Unknown | New York Medical College | 20 | 2018-08-22 | 2019-03-14 |
| Central Nervous System Vascular Changes in Adult Sickle Cell Disease and the Effect of Treatment With Simvastatin Simvastatin 40mg - Sickle Cell Disease, Stroke | Phase 1 / Phase 2 | Unknown | University of Campinas, Brazil | 28 | 2018-03-05 | 2020-10-12 |
| A Phase - IIa - IIb, Trial to Study the Safety, Tolerability and Efficacy of Memantine as a Long-term Treatment of SCD Memantine Hydrochloride - Sickle Cell Disease | Phase 2 | Unknown | HaEmek Medical Center, Israel | 40 | 2018-02-02 | 2019-11-01 |
| Dose-Finding Study of SC411 in Children With Sickle Cell Disease Docosahexaenoic Acid, Placebo - Sickle Cell Disease | Phase 2 | Unknown | Micelle BioPharma Inc | 68 | 2017-03-02 | 2019-01-31 |
| HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen Fludarabine monophosphate - Sickle Cell Disease | Phase 2 | Unknown | National Guard Health Affairs | 15 | 2016-05-01 | 2016-05-19 |
| Vascular Function Intervention Trial in Sickle Cell Disease Vascular ready-to-use supplementary food, Regular Ready-to-use supplementary food, Chloroquine - Sickle Cell Disease | Phase 2 / Phase 3 | Unknown | London School of Hygiene and Tropical Medicine | 120 | 2012-08-01 | 2016-07-27 |
| Study Of Efficacy,Safety of Combined Deferasirox and Deferiprone Versus Combined Deferiprone and Desferal In Conditions of Iron Overload DFP (ferriprox) and deferasirox (ICL 670), DFP, DFO - Beta-thalassemia Major, Sickle Cell Disease | Phase 2 / Phase 3 | Unknown | Ain Shams University | 60 | 2012-02-01 | 2012-02-06 |
| A Randomized Trial of LOVAZA in Pediatric Sickle Cell Disease (SCD) Omega-3 Fatty Acids: Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA), Placebo Capsules - Sickle Cell Disease, HEMOGLOBIN SS | Phase 2 | Unknown | Thomas Jefferson University | 48 | 2010-10-01 | 2010-10-25 |
| Autologous Bone Marrow Stem Cell Transplantation for Osteonecrosis in Sickle Cell Disease Autologous bone marrow stem cell graft - Avascular Necrosis of Bone, Sickle Cell Disease | Phase 1 / Phase 2 | Unknown | Federal University of Bahia | 100 | 2006-08-01 | 2017-11-20 |
| Stem Cell Transplant in Sickle Cell Disease and Thalassemia Busulfan, Fludarabine, Alemtuzumab - Sickle Cell Disease, Beta Thalassemia | Phase 2 | Unknown | Columbia University | 53 | 2004-09-01 | 2024-06-13 |
Anemia, Sickle Cell (14) · beta-Thalassemia (2) · Acquired Immunodeficiency Syndrome (1) · Acute Pain (1) · Amyotrophic Lateral Sclerosis (1) · Anemia, Hemolytic (1) · Anxiety Disorders (1) · Autistic Disorder (1) · Bipolar Disorder (1) · Brain Injuries, Traumatic (1) · COVID-19 (1) · Chronic Pain (1) · Chronic Traumatic Encephalopathy (1) · Colitis, Ulcerative (1) · Coronavirus Infections (1)
Anemia (14) · Anemia, Hemolytic, Congenital (14) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (14) · Genetic Diseases, Inborn (14) · Hematologic Diseases (14) · Hemic and Lymphatic Diseases (14) · Hemoglobinopathies (14) · Anemia, Hemolytic (13) · Pathological Conditions, Signs and Symptoms (5) · Pathologic Processes (4) · Brain Diseases (2) · Cardiovascular Diseases (2) · Central Nervous System Diseases (2) · Immune System Diseases (2) · Musculoskeletal Diseases (2)
Docosahexaenoic Acids (2) · fludarabine phosphate (2) · Alemtuzumab (1) · Busulfan (1) · Chloroquine (1) · Deferasirox (1) · Deferiprone (1) · Deferoxamine (1) · Eicosapentaenoic Acid (1) · Fatty Acids, Omega-3 (1) · Fish Oils (1) · Hemoglobin, Sickle (1) · Isoflurophate (1) · Medical Marijuana (1) · Melphalan (1)
Ain Shams University (1) · Assistance Publique - Hôpitaux de Paris (1) · Columbia University (1) · Community Medical Center, Toms River, NJ (1) · Federal University of Bahia (1) · Guy's and St Thomas' NHS Foundation Trust (1) · HaEmek Medical Center, Israel (1) · London School of Hygiene and Tropical Medicine (1) · Micelle BioPharma Inc (1) · National Guard Health Affairs (1) · New York Medical College (1) · OMNI Medical Services, LLC (1) · Thomas Jefferson University (1) · University of Campinas, Brazil (1)
United States (6) · Brazil (1) · Egypt (1) · France (1) · Israel (1) · Saudi Arabia (1) · Tanzania (1) · United Kingdom (1)
Ariel Koren, Professor (1) · Bruno Benites, MD (1) · Dr. Ryan O Lakin, MD JD (1) · Eugene Oteng-Ntim (1) · GIldasio Daltro, MD (1) · Marie Stuart, M.D. (1) · Matthew Heeney, MD (1) · Mohsen S. Elalfy, professour (1) · Monica Bhatia, MD (1) · Pierre-Andre Natella, PHD (1) · Radovan Borojevic, PhD (1) · Roberto Meyer, MD (1) · Sharon Cox, PhD (1) · Shreni Zinzuwadia, MD (1) · Vitor Fortuna, PhD (1)
PMID 24797180, PMID 25600572, PMID 26021713, PMID 29548623, PMID 29788942, PMID 30097463, PMID 32312326, PMID 38775255, PMID 38954844, PMID 41603130