21 completed, 2 terminated, 2 unknown, 1 active not recruiting. 30 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 30 | Completed 21, Terminated 2, Unknown 2, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Suspended 1, Withdrawn 1 |
Follow Sickle Cell Anemia: new trials by email Literature Review of Sickle Cell Anemia trials Research Report on Sickle Cell Anemia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Awake Prone Positioning for Severe Acute Chest Syndrome Awake prone positioning (APP) - Acute Chest Syndrome, Sickle Cell Anemia | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 15 | 2026-01-01 | 2025-09-02 |
| Feasibility and Preliminary Efficacy of Acceptance and Commitment Therapy (ACT) for Sleep Disturbances in Adults With Sickle Cell Disease (SCD) ACT Intervention, Waitlist - Sickle Cell Disease, Sickle Cell Anemia | Not applicable | Suspended | National Cancer Institute (NCI) | 3 | 2024-05-03 | 2025-11-20 |
| Pressure Pain Tolerance in Relation to Balance and Strength in Children Pressure pain tolerance measurement using Digital Pressure Algometer, Balance assessment using HUMAC balance system, Lower limb muscular strength using Lafayette hand held dynamometer - Sickle Cell Anemia | Not applicable | Recruiting | Adly A Adam | 80 | 2024-02-01 | 2025-04-01 |
| Sickle Cell Disease (SCD) Bone Pain Study Dual-energy X-ray absorptiometry, Vertebral fracture analysis, Adult Sickle Cell Quality of Life Measurement System pain impact questionnaire - Sickle Cell Disease, Sickle Cell Anemia | Not applicable | Active not recruiting | University of California, Davis | 53 | 2022-11-03 | 2026-09-23 |
| The Montreal Cognitive Assessment.Test in Adults With Sickle Cell Disease Montreal cognitive assessment - Sickle Cell Anemia | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 65 | 2022-10-20 | 2026-02-10 |
| Physical Rehabilitation in Sickle Cell Anemia Physical activity - Sickle Cell Anemia, Muscle Dysfunction | Not applicable | Unknown | Centro Universitário Augusto Motta | 40 | 2020-01-31 | 2021-04-27 |
| To Assess Safety, Tolerability and Physiological Effects on Structure and Function of AXA4010 in Subjects With Sickle Cell Disease AXA4010 - To Assess the Safety and Tolerabiltiy of an Amino Acid Composition in Subjects With Sickle Cell Disease, Anemia, Sickle Cell | Not applicable | Completed | Axcella Health, Inc | 9 | 2019-09-25 | 2021-04-01 |
| Shared-Decision Making for Hydroxyurea Hydroxyurea SDM Toolkit, Clinician Pocket Guide - Sickle Cell Anemia, Children, Only | Not applicable | Completed | Children's Hospital Medical Center, Cincinnati | 176 | 2018-07-12 | 2025-06-13 |
| The Influence of micro-and Macro Vascular Dysfunction on Clinical Severity in Adults With Sickle Cell Anemia (SS) and Sickle Cell Hemoglobin C Disease (SC) The influence of micro-and macro vascular dysfunction on clinical severity in adults with sickle cell anemia (SS) and sickle cell hemoglobin C disease (SC) - Sickle Cell Anemia | Not applicable | Completed | Centre Hospitalier Universitaire de la Guadeloupe | 49 | 2016-04-29 | 2025-12-11 |
| SACRED A Prospective Research Study to Reduce Stroke in Children With Sickle Cell Anemia Hydroxyurea, TCD examination - Sickle Cell Anemia | Not applicable | Completed | Children's Hospital Medical Center, Cincinnati | 283 | 2016-03-16 | 2025-08-22 |
| Carbon Monoxide Measurement to Screen for Sickle Cell Disease End-tidal Carbon Monoxide Subjects, End-tidal Carbon Monoxide Controls - Sickle Cell Anemia | Not applicable | Completed | UCSF Benioff Children's Hospital Oakland | 32 | 2015-07-01 | 2021-06-09 |
| Evaluation of the AMICUS RBCx System in Sickle Cell Patients Amicus Red Cell Exchange in SCD patients - Sickle Cell Anemia | Not applicable | Completed | Fenwal, Inc. | 83 | 2015-05-01 | 2022-07-29 |
| Decision Aid for Therapeutic Options In Sickle Cell Disease Decision Aid Tool, Standard Practice - Sickle Cell Disease, Sickle Cell Anemia | Not applicable | Completed | Emory University | 134 | 2015-01-01 | 2018-10-09 |
| Effect of Exercise With and Without HMB on Body Composition and Muscle Strength in Sickle Cell Anaemia Resistance exercise, β-hydroxy-β-methylbutyrate, placebo - Sickle Cell Anemia | Not applicable | Unknown | The University of The West Indies | 24 | 2013-04-30 | 2019-06-28 |
| Sickle Cell Disease - Stroke Prevention in Nigeria Trial Hydroxyurea - Sickle Cell Anemia, Sickle Cell Disease | Not applicable | Completed | Vanderbilt University Medical Center | 29 | 2013-04-24 | 2020-08-03 |
| Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders Haploidentical Bone Marrow/Kidney - Chronic Kidney Disease, Acute Myeloid Leukemia (AML) | Not applicable | Completed | Massachusetts General Hospital | 10 | 2012-11-01 | 2026-03-06 |
| Carbon Monoxide Monitor for the Measurement of End-Tidal Carbon Monoxide Levels in Children With or Without Hemolysis Measurement of carbon monoxide level in exhaled breath - Sickle Cell Anemia | Not applicable | Completed | Ashutosh Lal | 40 | 2012-10-01 | 2014-06-02 |
| Microvascular Blood Flow in Sickle Cell Anemia regadenoson infusion with contrast-enhanced ultrasound, contrast-enhanced ultrasound - Sickle Cell Disease, Sickle Cell Anemia | Not applicable | Completed | Versiti Blood Health | 91 | 2012-07-01 | 2024-06-26 |
| Bi-Level Positive Airway Ventilation for Acute Chest Syndrome Bi-level positive airway pressure device, Sham CPAP - Sickle Cell Anemia, Acute Chest Syndrome | Not applicable | Terminated | Albert Einstein College of Medicine | 3 | 2012-07-01 | 2018-12-11 |
| Allogeneic Genoidentical Stem Cell Transplantation in Children With Sickle-cell Anemia and Cerebral Vasculopathy Stem cell transplantation, Transfusion program - Sickle Cell Anemia, Cerebrovascular Accident | Not applicable | Completed | Assistance Publique - Hôpitaux de Paris | 63 | 2010-12-01 | 2016-12-05 |
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Anemia, Sickle Cell (30) · Genetic Diseases, Inborn (5) · Hematologic Diseases (4) · Pain (4) · Rare Diseases (4) · Anemia (3) · Acute Chest Syndrome (2) · Anemia, Diamond-Blackfan (2) · Hemoglobin SC Disease (2) · Osteonecrosis (2) · Stroke (2) · Anemia, Aplastic (1) · Anemia, Hemolytic, Congenital (1) · Arthritis (1) · Autoimmune Diseases (1)
Anemia, Hemolytic (30) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (30) · Hemic and Lymphatic Diseases (30) · Anemia, Hemolytic, Congenital (29) · Hemoglobinopathies (29) · Anemia (27) · Hematologic Diseases (26) · Genetic Diseases, Inborn (25) · Pathological Conditions, Signs and Symptoms (8) · Pathologic Processes (6) · Disease Attributes (5) · Neurologic Manifestations (4) · Signs and Symptoms (4) · Cardiovascular Diseases (3) · Metabolic Diseases (3)
Hydroxyurea (4) · Cyclophosphamide (2) · Absorptiometry, Photon (1) · Antilymphocyte Serum (1) · Bone Marrow Transplantation (1) · Bortezomib (1) · Busulfan (1) · Clotrimazole (1) · Cytarabine (1) · Exercise (1) · Fructose (1) · Mental Status and Dementia Tests (1) · Plasma Exchange (1) · Plasmapheresis (1) · Ranibizumab (1)
Assistance Publique - Hôpitaux de Paris (4) · Children's Hospital Medical Center, Cincinnati (2) · Duke University (2) · UCSF Benioff Children's Hospital Oakland (2) · Adly A Adam (1) · Albert Einstein College of Medicine (1) · Ashutosh Lal (1) · Axcella Health, Inc (1) · Boston Children's Hospital (1) · Centre Hospitalier Universitaire de la Guadeloupe (1) · Centro Universitário Augusto Motta (1) · Emory University (1) · Fairview University Medical Center (1) · Fenwal, Inc. (1) · HaEmek Medical Center, Israel (1)
United States (17) · France (4) · Brazil (1) · Dominican Republic (1) · Egypt (1) · Guadeloupe (1) · Israel (1) · Nigeria (1)
Ashutosh Lal, MD (2) · Agnaldo J Lopes, PhD (1) · Alexandre Elabbadi, MD (1) · Ariel Koren, MD (1) · Asha V Badaloo, PhD (1) · Carlo Brugnara (1) · Courtney D Thornburg, MD mS (1) · Courtney D Thornburg, MD, MS (1) · David Green (1) · Deepa Manwani, MD (1) · Elham M Salem, PHD (1) · Elliott P. Vichinsky (1) · Hiren Muzumdar, MD (1)
PMID 15877730, PMID 1944426, PMID 21228717, PMID 23103089, PMID 24675916, PMID 25471989, PMID 25662725, PMID 25773175, PMID 26547630, PMID 26969771, PMID 28110136, PMID 28174191, PMID 28576754, PMID 28821470, PMID 30667500, PMID 31151984, PMID 31799940, PMID 34018965, PMID 34411499, PMID 36794731, PMID 37011163, PMID 39820633, PMID 40568713, PMID 41135058
1RC2HL101496 (1), K23HL148310 (1), R01NS094041 (1), R21NS080639 (1)