48 completed. 48 Phase 1, 28 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 48 | Completed 48 |
| Phase 2 | 28 | Completed 28 |
Follow Shock: new trials by email Literature Review of Shock trials Research Report on Shock
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study in Healthy Subjects to Assess the Safety and Tolerability of a 120-hour Continuous Infusion of M6229 M6229, Placebo - Healthy Subjects | Phase 1 | Completed | Matisse Pharmaceuticals | 15 | 2024-11-21 | 2025-12-16 |
| Improvement of Organ Function by Apigenin in Elderly Patients With Sepsis apigenin, sterilized water - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | Zhujiang Hospital | 20 | 2023-09-01 | 2024-03-13 |
| Phase 1b MMV367 PK/PD and Safety in Healthy Adult Volunteers Experimentally Infected With Blood Stage P. Falciparum MMV367 3mg, P. falciparum IBSM infection, MMV367 5mg - Infections, Vector Borne Diseases | Phase 1 | Completed | Medicines for Malaria Venture | 12 | 2023-08-01 | 2025-12-10 |
| Alirocumab in Patients with Sepsis Alirocumab, Placebo - Sepsis | Phase 1 | Completed | Jonathan Sevransky | 50 | 2023-01-04 | 2025-03-24 |
| CONFOCAL-2 Interventional Pilot Study Autoregulation-based precision blood pressure management - Critical Illness, Respiratory Failure | Phase 1 / Phase 2 | Completed | Queen's University | 16 | 2022-07-29 | 2025-12-22 |
| Intravenously Administered M6229 in Critically Ill Sepsis Patients M6229 - Sepsis, Septic Shock | Phase 1 | Completed | A.P.J. Vlaar | 10 | 2022-04-05 | 2025-02-11 |
| Effect of Arterio-venous ECMO on Severe Sepsis and ARDS Meropenem Injection, A-V ECMO - Patients With Respiratory Failure and Shocked | Phase 1 / Phase 2 | Completed | Mohamed Gaber Allam | 100 | 2022-02-01 | 2022-04-12 |
| Safety and Tolerability Study of IV ST266 in COVID-19 Subjects ST266 - Cytokine Release Syndrome | Phase 1 | Completed | Noveome Biotherapeutics, formerly Stemnion | 12 | 2021-05-30 | 2022-06-15 |
| Effect of IMMUNEPOTENT-CRP on Serum Pro-Inflammatory Cytokines in Mild to Moderate COVID-19 IMMUNEPOTENT-CRP (I-CRP), Placebo Comparator - COVID-19, SARS-CoV2 Infection | Phase 1 / Phase 2 | Completed | Universidad Autonoma de Nuevo Leon | 80 | 2021-04-20 | 2024-11-08 |
| Menstrual Blood Stem Cells in Severe Covid-19 Allogeneic human menstrual blood stem cells secretome, Intravenous saline injection - Covid19, Cytokine Storm | Phase 1 / Phase 2 | Completed | Avicenna Research Institute | 29 | 2021-04-17 | 2021-09-02 |
| Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis Therapeutic plasma exchange - Septic Shock | Phase 1 | Completed | Alberta Health Services, Calgary | 17 | 2020-10-21 | 2025-10-03 |
| Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation Meropenem, bronchoscopy, ventilator - ARDS, Septic Shock | Phase 1 / Phase 2 | Completed | King Abdul Aziz Specialist Hospital | 200 | 2020-07-02 | 2023-10-10 |
| Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation Meropenem, bronchoscopy, ventilator - ARDS, Septic Shock | Phase 1 / Phase 2 | Completed | King Abdul Aziz Specialist Hospital | 200 | 2020-07-02 | 2022-07-06 |
| Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged Ventilation Meropenem, bronchoscopy, ventilator - ARDS, Septic Shock | Phase 1 / Phase 2 | Completed | King Abdul Aziz Specialist Hospital | 200 | 2020-07-02 | 2023-10-10 |
| Clinical Use of Stem Cells for the Treatment of Covid-19 MSC Treatment, Saline Control - Covid19, Pneumonia | Phase 1 / Phase 2 | Completed | SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi | 30 | 2020-04-01 | 2021-05-25 |
| LIPIDS-P Trial Phase I/II Trial Smoflipid - Sepsis, Severe, Septic Shock | Phase 1 / Phase 2 | Completed | University of Florida | 59 | 2018-08-17 | 2025-08-11 |
| Tocilizumab for Cytokine Release Syndrome Prophylaxis in Haploidentical Transplantation Tocilizumab - Cytokine Release Syndrome, Stem Cell Transplant Complications | Phase 1 / Phase 2 | Completed | Hospital Universitario Dr. Jose E. Gonzalez | 30 | 2018-05-25 | 2021-03-08 |
| Effect of Mesenchymal Stromal Cells on Sepsis and Septic Shock Mesenchymal stem cells - Sepsis, Septic Shock | Phase 1 / Phase 2 | Completed | TC Erciyes University | 30 | 2018-03-11 | 2022-03-16 |
| The Effect of Remote Ischemic Conditioning on the Microcirculation in Sepsis Remote ischemic conditioning - Septic Shock, Sepsis | Phase 1 / Phase 2 | Completed | Lithuanian University of Health Sciences | 26 | 2018-02-01 | 2021-03-03 |
| Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study Lactated Ringer, Normal saline - Shock, Septic | Phase 1 | Completed | Children's Hospital of Philadelphia | 50 | 2018-01-24 | 2019-08-05 |
Showing 20 of 48. Sign in to see all of them.
Shock, Septic (29) · Sepsis (23) · Cytokine Release Syndrome (6) · Systemic Inflammatory Response Syndrome (5) · COVID-19 (4) · Inflammation (3) · Critical Illness (2) · Infections (2) · Pneumonia (2) · Respiratory Insufficiency (2) · Shock, Hemorrhagic (2) · Wounds and Injuries (2) · Acute Kidney Injury (1) · Acute Lung Injury (1)
Pathological Conditions, Signs and Symptoms (48) · Pathologic Processes (47) · Inflammation (37) · Infections (36) · Systemic Inflammatory Response Syndrome (35) · Respiratory Tract Diseases (10) · Sepsis (10) · Lung Diseases (7) · Respiratory Tract Infections (5) · Virus Diseases (5) · Coronaviridae Infections (4) · Nidovirales Infections (4) · Pneumonia, Viral (4) · RNA Virus Infections (4)
Meropenem (4) · Bronchoscopy (3) · Ventilators, Mechanical (3) · Propofol (2) · Saline Solution (2) · 2-(phenylmethyl)-1-naphthol (1) · AB103 (1) · Acetylcarnitine (1) · Aluminum Hydroxide (1) · Angiotensin II (1) · Apigenin (1) · Ascorbic Acid (1) · Ceftaroline (1) · Central Venous Catheters (1) · Cyclophosphamide (1)
Beth Israel Deaconess Medical Center (3) · King Abdul Aziz Specialist Hospital (3) · Biomedizinische Forschungs gmbH (2) · Jinhua Central Hospital (2) · Southeast University, China (2) · A.P.J. Vlaar (1) · Alberta Health Services, Calgary (1) · Atox Bio Ltd (1) · Austin Health (1) · Avicenna Research Institute (1) · Cancer Research UK (1) · Children's Hospital Medical Center, Cincinnati (1) · Children's Hospital of Philadelphia (1) · Critical Biologics Corporation (1) · Dr. Hasan Alam (1)
United States (17) · China (5) · Canada (4) · Saudi Arabia (4) · Australia (3) · Germany (2) · Mexico (2) · Netherlands (2) · Turkey (Türkiye) (2) · Austria (1) · Belgium (1) · Egypt (1) · Hong Kong (1) · Iran (1) · Lithuania (1)
Martha M Eibl, MD (2) · Michael W Donnino, MD (2) · Alan Cross, MD (1) · Alan E Jones, MD (1) · Alexander P Vlaar, MD, PhD, MBA (1) · Ali Dehghan-Manshadi, MD (1) · Alpha Fowler, MD (1) · Anthony F Suffredini, M.D. (1) · Benoit Bestgen, PhD (1) · Bernd Jilma, MD (1) · Cristina Rodriguez-Padilla, Ph.D. (1) · Daniel Talmor, MD, MPH (1) · David L Steed, MD (1)
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