7 recruiting, 4 completed, 4 not yet recruiting, 1 enrolling by invitation. 3 Not applicable, 1 Phase 2, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 3 | Not yet recruiting 2, Completed 1 |
| Phase 2 | 1 | Recruiting 1 |
| Phase 3 | 1 | Recruiting 1 |
| Phase 4 | 1 | Recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HOPE-Sepsis: Hemoadsorption Therapy for Sepsis Hemoperfusion with CA330 Cytokine Adsorption Column - Sepsis and Septic Shock | Not applicable | Not yet recruiting | Shanghai Zhongshan Hospital | 30 | 2026-10-01 | 2026-10-08 |
| Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge. Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge. - Sepsis and Septic Shock | Recruiting | Menoufia University | 115 | 2026-10-01 | 2026-10-06 | |
| Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure Hydrocortisone Hemisuccinate: 200 mg per day., reduction of the level of immunosuppression - Sepsis and Septic Shock, Acute Respiratory Failure | Phase 4 | Recruiting | University Hospital, Strasbourg, France | 212 | 2026-08-11 | 2026-08-20 |
| EEG Changes and Cognitive Profiles in Sepsis Patients With Different Inflammatory Phenotypes EEG monitoring - Sepsis, Sepsis Associated Encephalopathy | Not yet recruiting | Xiangya Hospital of Central South University | 78 | 2026-08-01 | 2026-08-12 | |
| MIRNA QUANTIFICATION IN PATIENTS WITH SEPTIC SHOCK Sepsis and Septic Shock | Recruiting | Insel Gruppe AG, University Hospital Bern | 56 | 2026-06-01 | 2026-06-02 | |
| Hemodynamic Venous Congestion Ultrasound (VExUS) by ICU Nurses in Sepsis Patients. Education in performing hemodynamic diagnostic ultrasound of venous congestion, Hemodynamic diagnostic ultrasound of venous congestion - Sepsis, Sepsis and Septic Shock | Not yet recruiting | Region Örebro County | 46 | 2026-04-01 | 2026-02-18 | |
| Adjunctive Fludrocortisone in Septic Shock Fludrocortisone 100 mcg daily, Placebo - Sepsis, Septic Shock | Phase 2 | Recruiting | Chinese University of Hong Kong | 32 | 2026-04-01 | 2026-06-02 |
| Written Sepsis Education for Patients Written Discharge Education, Usual Care - Sepsis, Sepsis and Septic Shock | Not applicable | Not yet recruiting | McMaster University | 30 | 2026-02-01 | 2026-03-03 |
| A Combination Therapy With Ceftazidime and Fosfomycin Will be Compared to Ceftazidime Alone in Hospitalized Adult Patients With Suspected Severe Gram-negative Bacterial Infections Ceftazidime± avibactam with fosfomycin, Ceftazidime± avibactam with placebo - Gram Negative Infections, Sepsis and Septic Shock | Phase 3 | Recruiting | Angela HUTTNER | 100 | 2025-08-25 | 2025-09-26 |
| Association of Arterio-Venous Oxygen and Carbon Dioxide Gradients With Tissue Hypoperfusion and Mortality in Sepsis Intubated ICU Patients, Sepsis and Septic Shock | Completed | Gaziosmanpasa Research and Education Hospital | 88 | 2025-03-01 | 2026-07-17 | |
| Role of Transposable Elements in Septic Immune Aging RNA and DNA Sequencing - Sepsis, Sepsis and Septic Shock | Recruiting | University of California, San Francisco | 116 | 2025-02-14 | 2026-01-30 | |
| Fibrinolysis Resistance in Infection and Trauma Viscoelastometric assessment of fibrinolysis - Sepsis and Septic Shock, Trauma | Recruiting | Anders Aneman | 150 | 2024-06-01 | 2024-11-08 | |
| Proteinuria During Sepsis and Septic Shock: Characterization and Association With ARDS Sepsis and Septic Shock | Unknown | Centre Hospitalier Intercommunal André Grégoire | 100 | 2023-05-23 | 2024-06-27 | |
| The Prognostic Impact of Right Ventricular Systolic Dysfunction on the Survival of Patients With Sepsis and Septic Shock Sepsis and Septic Shock | Completed | Burapha University | 200 | 2022-10-01 | 2024-01-05 | |
| Thiamine, Ascorbic Acid, and Their Combination on MMP-9/TIMP-1 and Inflammatory Balance in Sepsis Thiamine, Ascorbic Acid Injectable Product, Normal Saline 0.9% Injectable Solution - Sepsis and Septic Shock | Not applicable | Completed | Universitas Sumatera Utara | 40 | 2020-04-01 | 2026-08-26 |
| Study on the Construction and Application of Early Warning Model of Sepsis in Critically Ill Patients Sepsis, Sepsis and Septic Shock | Enrolling by invitation | Second Affiliated Hospital of Wenzhou Medical University | 100 | 2019-01-01 | 2025-04-01 | |
| Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient paracetamol - Sepsis and Septic Shock | Completed | Università Politecnica delle Marche | 50 | 2017-07-05 | 2019-07-18 |
Sepsis (17) · Shock, Septic (17) · Cognitive Dysfunction (1) · Coinfection (1) · Hyperemia (1) · Infections (1) · Proteinuria (1) · Sepsis-Associated Encephalopathy (1) · Wounds and Injuries (1)
Inflammation (17) · Pathologic Processes (17) · Pathological Conditions, Signs and Symptoms (17) · Shock (17) · Systemic Inflammatory Response Syndrome (17) · Infections (16) · Brain Diseases (1) · Cardiovascular Diseases (1) · Central Nervous System Diseases (1) · Cognition Disorders (1) · Female Urogenital Diseases (1) · Female Urogenital Diseases and Pregnancy Complications (1) · Male Urogenital Diseases (1) · Mental Disorders (1) · Nervous System Diseases (1)
Acetaminophen (1) · Educational Status (1) · Fludrocortisone (1) · Fosfomycin (1) · Hemoperfusion (1) · RNA (1) · Saline Solution (1) · Sequence Analysis, DNA (1) · Thiamine (1) · avibactam, ceftazidime drug combination (1) · hydrocortisone hemisuccinate (1)
Anders Aneman (1) · Angela HUTTNER (1) · Burapha University (1) · Centre Hospitalier Intercommunal André Grégoire (1) · Chinese University of Hong Kong (1) · Gaziosmanpasa Research and Education Hospital (1) · Insel Gruppe AG, University Hospital Bern (1) · McMaster University (1) · Menoufia University (1) · Region Örebro County (1) · Second Affiliated Hospital of Wenzhou Medical University (1) · Shanghai Zhongshan Hospital (1) · Universitas Sumatera Utara (1) · University Hospital, Strasbourg, France (1) · University of California, San Francisco (1)
China (3) · France (2) · Switzerland (2) · Australia (1) · Egypt (1) · Hong Kong (1) · Indonesia (1) · Italy (1) · Thailand (1) · Turkey (Türkiye) (1) · United States (1)
Alexendar R Perez, M.D., Ph.D (1) · Alison Fox-Robichaud, MD, MSc (1) · Judith Hellman, M.D. (1) · Matthieu Legrand, M.D., Ph.D (1) · Ming Zhong, Ph.D (1)