6 completed, 4 recruiting, 2 active not recruiting, 2 enrolling by invitation. 7 Not applicable, 2 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 2, Recruiting 2, Active not recruiting 1, Enrolling by invitation 1, Unknown 1 |
| Phase 1 | 2 | Active not recruiting 1, Completed 1 |
| Phase 4 | 1 | Completed 1 |
Follow Semantic Dementia: new trials by email Literature Review of Semantic Dementia trials Research Report on Semantic Dementia
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intervention for Communication Quality of Life in Primary Progressive Aphasia Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia - Primary Progressive Aphasia(PPA), Semantic Dementia | Not applicable | Recruiting | Maya Henry | 30 | 2026-04-01 | 2026-04-21 |
| Revealing Engagement Dynamics Among Semantic Dementia Patients Semantic Dementia | Not yet recruiting | Power Life Sciences Inc. | 500 | 2025-02-01 | 2024-01-23 | |
| Primary Progressive Aphasia Multicomponent Language Treatment Study Multicomponent Lexical Retrieval Training (Multi-LRT), Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA), Multicomponent Communication Partner Training (Multi-CPT) - Primary Progressive Aphasia, Semantic Dementia | Not applicable | Enrolling by invitation | University of Texas at Austin | 21 | 2023-05-02 | 2025-10-08 |
| Home-Based Exercise in Primary Progressive Aphasia (HEPPA) Home-based multicomponent exercise intervention program - Primary Progressive Aphasia, Neurodegenerative Diseases | Not applicable | Completed | Montreal Heart Institute | 13 | 2023-04-05 | 2025-02-06 |
| Memory and Social Interactions Learning new information - Alzheimer Disease, Semantic Dementia | Recruiting | University Hospital, Caen | 192 | 2023-03-10 | 2024-09-20 | |
| Veri-T: A Trial of Verdiperstat in Patients With svPPA Due to TDP-43 Pathology Verdiperstat - Semantic Dementia | Phase 1 | Active not recruiting | Peter Ljubenkov, MD | 64 | 2022-04-14 | 2026-07-06 |
| Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders C-11 PiB, AV1451 Tau, C-11 ER176 - PSP, CBD | Enrolling by invitation | Mayo Clinic | 500 | 2020-11-01 | 2025-11-21 | |
| Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease Metacognition tests - Semantic Dementia, Alzheimer Disease | Completed | University Hospital, Grenoble | 40 | 2020-10-16 | 2023-08-07 | |
| Evaluation of a Transcranial Stimulation With Direct Current on Language Disorders in Semantic Dementia Transcranial stimulation - Semantic Dementia | Not applicable | Unknown | Assistance Publique - Hôpitaux de Paris | 80 | 2018-05-16 | 2024-01-17 |
| Treatment for Speech and Language in Primary Progressive Aphasia Lexical Retrieval Training (LRT), Video-Implemented Script Training for Aphasia (VISTA) - Primary Progressive Aphasia, Semantic Dementia | Not applicable | Active not recruiting | University of Texas at Austin | 60 | 2017-07-01 | 2025-11-13 |
| The Swedish BioFINDER 2 Study Flutemetamol F18 Injection, [18F]-RO6958948, Elecsys (Roche) Abeta42, Ttau and Ptau - Dementia, Alzheimer Disease | Not applicable | Recruiting | Skane University Hospital | 2950 | 2017-05-15 | 2026-04-06 |
| Diagnosing Frontotemporal Lobar Degeneration Observational Study - Corticobasal Syndrome, Progressive Supranuclear Palsy | Recruiting | University Health Network, Toronto | 100 | 2015-08-01 | 2025-03-30 | |
| Evaluation and Characterization of Behavioural Disorders and Dementias by the Behavioural Dysexecutive Syndrome Inventory (BDSI) prevalence of behavioural dysexecutive syndrome - Frontotemporal Dementia, Huntington Disease | Completed | Centre Hospitalier Universitaire, Amiens | 49 | 2013-01-29 | 2020-07-20 | |
| PiB PET Scanning in Speech and Language Based Dementias C-11 PiB, F-18 FDG - PPA, Primary Progressive Aphasia | Phase 1 | Completed | Mayo Clinic | 168 | 2010-03-01 | 2015-12-22 |
| Language Treatment for Progressive Aphasia Errorless learning - Primary Progressive Aphasia, Nonfluent Progressive Aphasia | Not applicable | Completed | Baycrest | 7 | 2009-08-01 | 2015-01-27 |
| Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia memantine, Placebo pill - Frontal Lobe Dementia, Frontotemporal Lobe Dementia | Phase 4 | Completed | University of California, San Francisco | 81 | 2007-10-01 | 2020-11-17 |
Frontotemporal Dementia (16) · Aphasia, Primary Progressive (7) · Primary Progressive Nonfluent Aphasia (7) · Aphasia (6) · Alzheimer Disease (4) · Neurodegenerative Diseases (3) · Aphasia, Broca (2) · Apraxias (2) · Cognitive Dysfunction (2) · Corticobasal Degeneration (2) · Dementia (2) · Memory Disorders (2) · Parkinson Disease (2) · Pick Disease of the Brain (2) · Supranuclear Palsy, Progressive (2)
Brain Diseases (16) · Central Nervous System Diseases (16) · Frontotemporal Lobar Degeneration (16) · Metabolic Diseases (16) · Nervous System Diseases (16) · Neurocognitive Disorders (16) · Nutritional and Metabolic Diseases (16) · Proteostasis Deficiencies (16) · TDP-43 Proteinopathies (16) · Mental Disorders (15) · Dementia (14) · Neurodegenerative Diseases (13) · Communication Disorders (10) · Language Disorders (10) · Neurobehavioral Manifestations (10)
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (2) · Memantine (1) · Observation (1) · Therapeutics (1)
Mayo Clinic (2) · University of Texas at Austin (2) · Assistance Publique - Hôpitaux de Paris (1) · Baycrest (1) · Centre Hospitalier Universitaire, Amiens (1) · Maya Henry (1) · Montreal Heart Institute (1) · Peter Ljubenkov, MD (1) · Power Life Sciences Inc. (1) · Skane University Hospital (1) · University Health Network, Toronto (1) · University Hospital, Caen (1) · University Hospital, Grenoble (1) · University of California, San Francisco (1)
United States (8) · France (4) · Canada (3) · Sweden (1) · Switzerland (1)
Maya L Henry, PhD (3) · Adam L. Boxer, M.D., Ph.D. (1) · Bruce Miller, M.D. (1) · Erik Stomrud, MD, Phd (1) · Keith A Josephs, M.D. MST, MSc (1) · Louis Bherer (1) · Maria C Tartaglia, M.D. (1) · Michael B Gill (1) · Peter Ljubenkov, MD (1) · Regina Jokel, PhD (1) · Stephanie M Grasso, PhD (1)
PMID 23290598, PMID 31747967, PMID 34937781, PMID 38807183, PMID 41864233
R01AG073482 (1), R01DC016291 (1), R56DC016291 (1)