10 completed, 5 unknown, 2 active not recruiting, 2 recruiting. 24 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 24 | Completed 10, Unknown 5, Active not recruiting 2, Recruiting 2, Terminated 2, Withdrawn 2, Enrolling by invitation 1 |
Follow Scleroderma, Systemic: new trials by email Literature Review of Scleroderma, Systemic trials Research Report on Scleroderma, Systemic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic Diseases Dengue 1,2,3,4 (attenuated) vaccine - Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA) | Phase 4 | Recruiting | University of Sao Paulo General Hospital | 477 | 2026-03-16 | 2026-07-20 |
| Open Label Treprostinil Raynaud's Study Oral treprostinil (UT-15C) sustained release tablets - Raynaud's Disease, Raynaud Phenomena | Phase 4 | Recruiting | Brigham and Women's Hospital | 30 | 2025-10-15 | 2026-03-24 |
| Efficacy of Tofacitinib on Skin Thickening in Diffuse Cutaneous Systemic Sclerosis: A Comparative Study With Methotrexate Tofacitinib, Methotrexate - Scleroderma, Systemic | Phase 4 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 34 | 2024-12-21 | 2026-03-16 |
| Vaccination Against Herpes Zoster in Patients With Inflammatory Rheumatic Diseases Shingrix, vaccination with 2 doses of Shingrix vaccine - Systemic Vasculitis, Spondylarthropathies | Phase 4 | Enrolling by invitation | Region Skane | 240 | 2024-12-17 | 2025-01-10 |
| The Safety and Efficacy of Telitacicept in the Treatment of Systemic Sclerosis Telitacicept - Systemic Sclerosis | Phase 4 | Unknown | Peking University Third Hospital | 20 | 2024-06-08 | 2024-08-09 |
| Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation - Rheumatoid Arthritis, Spondylitis, Ankylosing | Phase 4 | Active not recruiting | University of Sao Paulo General Hospital | 2005 | 2023-05-23 | 2026-05-04 |
| Efficacy and Safety of Pirfenidone in CTD-ILD Pirfenidone, glucocorticoid and immunosuppressant - Pirfenidone, Connective Tissue Diseases | Phase 4 | Unknown | Qilu Hospital of Shandong University | 120 | 2022-06-22 | 2022-11-30 |
| A Study Evaluating the Efficacy and Safety of Baricitinib in Systemic Sclerosis Baricitinib, Cyclophosphamide - Systemic Sclerosis | Phase 4 | Active not recruiting | Tongji Hospital | 60 | 2022-03-08 | 2026-01-27 |
| Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis Upfront autologous HSCT - Systemic Sclerosis, Systemic Scleroses, Diffuse | Phase 4 | Completed | UMC Utrecht | 60 | 2020-09-17 | 2026-03-24 |
| Immunosuppressant Combined With Pirfenidone in CTD-ILD Pirfenidone, DMARDs - Pirfenidone, Connective Tissue Diseases | Phase 4 | Unknown | Qilu Hospital of Shandong University | 200 | 2019-08-16 | 2023-11-18 |
| Evaluation of Effectiveness of Acetylsalicylic Acid on Markers of Vascular Dysfunction in Scleroderma Patients Acetylsalicylic acid, Placebo oral capsule - Systemic Sclerosis | Phase 4 | Completed | Federal University of São Paulo | 70 | 2018-08-28 | 2021-12-01 |
| Intraoperative ICG for Systemic Sclerosis Order of two elements of surgical procedure, Indocyanine Green - Systemic Sclerosis | Phase 4 | Withdrawn | Duke University | 2017-06-01 | 2020-06-30 | |
| To Compare the Efficacy of Combination Therapy vs Monotherapy for Pulmonary Arterial Hypertension in Systemic Sclerosis Sildenafil 20mg and Bosentan 62.5mg, Sildenafil 20mg and Placebo - Associated Pulmonary Arterial Hypertension | Phase 4 | Unknown | Post Graduate Institute of Medical Education and Research, Chandigarh | 50 | 2016-12-01 | 2017-02-15 |
| Efficacy and Safety of PLACENTEX ® i.m. in Patients With Scleroderma Diseases Polydeoxyribonucleotides - Scleroderma Disease | Phase 4 | Terminated | Mastelli S.r.l | 25 | 2016-11-08 | 2021-09-16 |
| The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis bosentan - Scleroderma, Systemic | Phase 4 | Completed | University Medical Center Groningen | 20 | 2015-06-26 | 2018-12-13 |
| Effectiveness of Saccharomyces Boulardii for Gastrointestinal Bacterial-overgrowth in Systemic Sclerosis Saccharomyces Boulardii Oral Tablet, Metronidazole - Systemic Sclerosis, Small Intestinal Bacterial Overgrowth | Phase 4 | Completed | Coordinación de Investigación en Salud, Mexico | 39 | 2015-06-01 | 2019-07-30 |
| Probiotics in Patients With Moderate-to-severe Distention/ Bloating From Systemic Sclerosis Lactobacillus - Scleroderma | Phase 4 | Withdrawn | University of Michigan | 2012-02-01 | 2016-12-22 | |
| Bosentan in Systemic Sclerosis Bosentan - Systemic Sclerosis, Digital Ulcers | Phase 4 | Completed | Actelion | 18 | 2011-03-31 | 2026-06-03 |
| Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Anti-pandemic H1N1 influenza vaccine - Rheumatoid Arthritis, Spondyloarthritis | Phase 4 | Unknown | University of Sao Paulo | 5000 | 2010-04-01 | 2010-06-28 |
| A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis tadalafil and ambrisentan upfront combination therapy - Pulmonary Arterial Hypertension, Systemic Sclerosis | Phase 4 | Completed | Johns Hopkins University | 25 | 2010-01-01 | 2017-09-12 |
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Scleroderma, Diffuse (7) · Arthritis, Rheumatoid (5) · Connective Tissue Diseases (5) · Arthritis, Juvenile (4) · Myositis (4) · Hypertension, Pulmonary (3) · Lupus Erythematosus, Systemic (3) · Systemic Vasculitis (3) · Antiphospholipid Syndrome (2) · Arthritis, Psoriatic (2) · Dermatomyositis (2) · Herpes Zoster (2) · Lung Diseases, Interstitial (2) · Raynaud Disease (2)
Skin Diseases (24) · Skin and Connective Tissue Diseases (24) · Connective Tissue Diseases (19) · Cardiovascular Diseases (9) · Vascular Diseases (9) · Immune System Diseases (7) · Respiratory Tract Diseases (7) · Autoimmune Diseases (6) · Joint Diseases (6) · Lung Diseases (6) · Muscular Diseases (6) · Musculoskeletal Diseases (6) · Nervous System Diseases (6) · Arthritis (5)
Bosentan (4) · ambrisentan (2) · pirfenidone (2) · Antirheumatic Agents (1) · Aspirin (1) · Cilostazol (1) · Cyclophosphamide (1) · Glucocorticoids (1) · Immunosuppressive Agents (1) · Indocyanine Green (1) · Lacteol (1) · Methotrexate (1) · Metronidazole (1) · Polydeoxyribonucleotides (1) · Sildenafil Citrate (1)
Actelion (2) · Qilu Hospital of Shandong University (2) · University of Sao Paulo General Hospital (2) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Brigham and Women's Hospital (1) · Coordinación de Investigación en Salud, Mexico (1) · Duke University (1) · Federal University of São Paulo (1) · Johns Hopkins University (1) · Mastelli S.r.l (1) · Otsuka America Pharmaceutical (1) · Peking University Third Hospital (1) · Post Graduate Institute of Medical Education and Research, Chandigarh (1) · Region Skane (1) · Tongji Hospital (1)
United States (5) · Brazil (4) · China (4) · Netherlands (3) · Italy (2) · Australia (1) · Bangladesh (1) · India (1) · Mexico (1) · Sweden (1) · United Kingdom (1)
Aaron B Waxman, MD, PhD (1) · Andries J Smit, MDPhD (1) · Cristiane Kayser, PhD (1) · David Celermajer, Professor (1) · Dinesh Khanna, MD (1) · Jacob M van Laar, MD PhD (1) · John C Fang, M.D. (1) · Julia Spierings (1) · Md. Abu Shahin, FCPS, MD (1) · Nandita Kakker, M.D (1) · Paul Hassoun, MD (1) · Rajeev Saggar, MD (1) · Simona Muratori, Dr (1)
PMID 21540203, PMID 21859696, PMID 22089462, PMID 22298793, PMID 22777623, PMID 22908326, PMID 22931582, PMID 22949223, PMID 22992045, PMID 23123020, PMID 23525305, PMID 23818263, PMID 24961747, PMID 26360334, PMID 28968874, PMID 29251556, PMID 31549334, PMID 33737437, PMID 41679320, PMID 41932224, PMID 42261247, PMID 42294825, PMID 42843284
2023 (1), P50HL084946 (1)