93 completed, 31 unknown, 24 recruiting, 10 not yet recruiting. 179 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 179 | Completed 93, Unknown 31, Recruiting 24, Not yet recruiting 10, Terminated 10, Active not recruiting 7, Withdrawn 3, Enrolling by invitation 1 |
Follow Scleroderma, Systemic: new trials by email Literature Review of Scleroderma, Systemic trials Research Report on Scleroderma, Systemic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigation of Type I Interferon Excess in Patients With Systemic Autoimmune Diseases and Genetic Type I Interferonopathies biological samples - Systememic Lupus Erythematosus, Systemic Sclerosis (SSc) | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 120 | 2026-12-01 | 2026-09-24 |
| Using AI-Assisted Cameras to Track Hand Exercises in Scleroderma Patients AI-powered, camera-based, exercise-focused telerehabilitation, Physiotherapist-supervised, exercise-focused rehabilitation - Systemic Scleroderma | Not applicable | Not yet recruiting | Istanbul University - Cerrahpasa | 40 | 2026-11-01 | 2026-10-14 |
| Small Airway Dysfunction in Rheumatoid Arthritis and Systemic Sclerosis Conventional PFT; IOS; CANO; Chest HRCT - Rhumatoid Arthisis, Systemic Sclerosis (SSc) | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 184 | 2026-11-01 | 2026-11-09 |
| Tissue Modeling in Systemic Sclerosis Using Induced Pluripotent Stem Cells (iPSCs) Blood Sample Collection - Systemic Sclerosis (SSc) | Not applicable | Recruiting | University Hospital, Montpellier | 16 | 2026-10-27 | 2026-10-29 |
| Home-based Exercise for Improving Health-related Quality of Life in Systemic Sclerosis Home-based exercise programme, Usual Care - Systemic Sclerosis (SSc) | Not applicable | Not yet recruiting | University of Aarhus | 270 | 2026-10-15 | 2026-09-25 |
| Extracellular Vesicle Dynamics Predicting Vascular Complications and Treatment Response in Systemic Sclerosis Blood sampling, nailfold capillaroscopy - Systemic Sclerosis, Pulmonary Arterial Hypertension | Not applicable | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 60 | 2026-09-01 | 2026-07-21 |
| Personalized Online Occupational Therapy Intervention for Adults With Scleroderma Personalized Online Occupational Therapy Intervention, Usual Care - Scleroderma, Scleroderma (Limited and Diffuse) | Not applicable | Completed | Universidad de Zaragoza | 24 | 2026-05-16 | 2026-10-14 |
| Exploratory Clinical Study of Anti-CD19/BCMA Universal CAR-T Cell Injection for the Treatment of Refractory Autoimmune Diseases anti-CD19/BCMA-UCAR-T cells - Rheumatoid Arthritis, Dermatomyositis | Not applicable | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 72 | 2026-05-10 | 2026-04-30 |
| Objective Assessment of Skin Damage Using ADHELASKIN in Patients With Systemic Sclerosis ADHELASKIN (Tactinnov° - Ecole centrale de Lyon) - D013493 | Not applicable | Recruiting | Centre Hospitalier Universitaire de Saint Etienne | 100 | 2026-05-07 | 2026-07-31 |
| Efficacy and Safety of Firsekibart in the Treatment of Systemic Sclerosis Firsekibart injection - Systemic Scleroderma | Not applicable | Not yet recruiting | Tongji Hospital | 30 | 2026-05-01 | 2026-04-20 |
| The Effect of Progressive Muscle Relaxation Exercises on Fatigue, Dyspnea, and Respiratory Function in Patients With Systemic Sclerosis Progressive Muscle Relaxation Exercise - Systemic Sclerosis (SSc) | Not applicable | Recruiting | University of Gaziantep | 50 | 2026-04-25 | 2026-10-08 |
| Systemic Sclerosis DIet for GastrointESTinal Symptoms Diet 1: Restriction of fermentable carbohydrates, Diet 2: Elimination of foods harmful to gut barrier and microbiome, Diet 3: Regular meal patterns, soluble fiber, and portion control - Systemic Sclerosis (SSc) | Not applicable | Recruiting | University of Michigan | 60 | 2026-03-16 | 2026-07-01 |
| Clinical Study of EVM18001 in the Treatment of Refractory Autoimmune Diseases EVM18001 Injection - System Lupus Erythematosus(SLE), Scleroderma | Not applicable | Recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 12 | 2026-03-12 | 2026-03-13 |
| A Study of CD19 UCAR-T Cells in Subjects With Autoimmune Diseases CD19 UCAR-T cells - Systemic Lupus Erythematosus, Idiopahic Inflammatory Myopathies | Not applicable | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 24 | 2026-01-30 | 2025-12-19 |
| Safety and Efficacy of Adipose-Derived Regenerative Cells (ADRCs) for Improving Hand Dysfunction in Systemic Sclerosis Autologous ADRCs injection Combined with Standard Therapy, Standard Treatment group - Systemic Sclerosis (SSc), Hand Dysfunction | Not applicable | Recruiting | Cytori Therapeutics | 48 | 2025-12-31 | 2026-01-22 |
| Evaluating Tools to Communicate Scleroderma Research Results to Patients - Trial #1 Plain-language summary, Dissemination Tool (Infographic) - Scleroderma, Systemic Sclerosis | Not applicable | Completed | Lady Davis Institute | 511 | 2025-12-05 | 2026-09-10 |
| Investigating the Effectiveness of the Biopsychosocial Model-Based Exercise Approach in Children and Adults Diagnosed With Scleroderma Cognitive Exercise Therapy Approach, Control group - Scleroderma, Scleroderma, Localized | Not applicable | Recruiting | Hacettepe University | 48 | 2025-12-04 | 2025-12-18 |
| Diffuse Cutaneous Scleroderma (DSSc) SFDI Study Spatial-frequency domain imaging (SFDI) - Systemic Scleroderma, Diffuse Cutaneous Scleroderma | Not applicable | Recruiting | Boston University | 65 | 2025-11-06 | 2026-07-23 |
| Anti CD19/BCMA CAR Gene Therapy for Autoimmune Diseases Anti-CD19/BCMA CAR gene vector injection will be injected intravenously on a one-time basis - Autoimmune Diseases | Not applicable | Recruiting | Anhui Provincial Hospital | 18 | 2025-08-25 | 2025-08-13 |
| CAR-T Cells Therapy for Patients With Autoimmune Diseases Anti-BCMA and CD19 CART cells will be injected intravenously on a one-time basis - Autoimmune Diseases | Not applicable | Recruiting | Anhui Provincial Hospital | 18 | 2025-07-20 | 2025-07-08 |
Showing 20 of 179. Sign in to see all of them.
Scleroderma, Diffuse (79) · Lupus Erythematosus, Systemic (18) · Arthritis, Rheumatoid (10) · Motor Activity (10) · Sjogren's Syndrome (10) · Myositis (9) · Raynaud Disease (8) · Autoimmune Diseases (7) · digital ulcers (6) · Antiphospholipid Syndrome (5) · Fatigue (5) · Hypertension, Pulmonary (5) · Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis (4) · Connective Tissue Diseases (4)
Skin Diseases (179) · Skin and Connective Tissue Diseases (179) · Connective Tissue Diseases (175) · Immune System Diseases (28) · Pathological Conditions, Signs and Symptoms (27) · Musculoskeletal Diseases (25) · Cardiovascular Diseases (23) · Vascular Diseases (22) · Autoimmune Diseases (19) · Joint Diseases (19) · Pathologic Processes (17) · Respiratory Tract Diseases (17) · Arthritis (16) · Nervous System Diseases (16)
Blood Specimen Collection (11) · Exercise (3) · Rehabilitation (3) · Biopsy (2) · Hematologic Tests (2) · Occupational Therapy (2) · ambrisentan (2) · Ambulatory Care Facilities (1) · Biofeedback, Psychology (1) · Bosentan (1) · Botulinum Toxins, Type A (1) · Butylated Hydroxytoluene (1) · Cholecalciferol (1) · Clinical Protocols (1) · Cognitive Behavioral Therapy (1)
University of Michigan (12) · Lady Davis Institute (9) · Assistance Publique - Hôpitaux de Paris (7) · Istanbul University (7) · University Hospital, Strasbourg, France (6) · Assistance Publique Hopitaux De Marseille (4) · Echosense Ltd. (4) · Poitiers University Hospital (4) · University Hospital, Lille (4) · Assiut University (3) · Firat University (3) · Pamukkale University (3) · University Hospital, Bordeaux (3) · University Hospital, Grenoble (3) · Anhui Provincial Hospital (2)
France (39) · United States (35) · Turkey (Türkiye) (20) · China (14) · Canada (12) · Italy (7) · Germany (5) · Israel (4) · Brazil (3) · South Korea (3) · Spain (3) · United Kingdom (3) · Austria (2) · Belgium (2) · Denmark (2)
David Launay, MD,PhD (3) · Luc Mouthon, MD, PhD (3) · Andreea Bujor, MD, PhD (2) · Brett D Thombs, PhD (2) · Brett Thombs, PhD (2) · Robyn T Domsic, MD (2) · Susan Murphy (2) · Alexsandra Balbir, Dr (1) · Ali Ismail, lecturer (1) · Amar Smail, MD (1)
PMID 29381834, PMID 16960939, PMID 17234649, PMID 21312348, PMID 21476099, PMID 21951278, PMID 22127844, PMID 22470237, PMID 24475856, PMID 24507585, PMID 24812476, PMID 24990822, PMID 25114060, PMID 27384349, PMID 27429171, PMID 27696703, PMID 27941129, PMID 28081972, PMID 28552512, PMID 29198478, PMID 29325173, PMID 29444467, PMID 29667474, PMID 29685482, PMID 29696997, PMID 29741230, PMID 29781586, PMID 29871697, PMID 30072999, PMID 30079996, PMID 30092330, PMID 30318128, PMID 30463598, PMID 30616671, PMID 30809542, PMID 30835186, PMID 30886963, PMID 30886964, PMID 31130325, PMID 31216880, PMID 31219594, PMID 31220505, PMID 31482431, PMID 31719073, PMID 31933034, PMID 32062031, PMID 32493508, PMID 32633087, PMID 32927933, PMID 33117350
2017 (1), R01AR081382 (1), R01AR085317 (1)