17 completed, 4 recruiting, 4 terminated, 3 withdrawn. 11 Not applicable, 7 Phase 2, 3 Phase 1, 2 Early Phase 1, 2 Phase 3.
Follow Scleroderma, Localized: new trials by email Literature Review of Scleroderma, Localized trials Research Report on Scleroderma, Localized
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigating the Effectiveness of the Biopsychosocial Model-Based Exercise Approach in Children and Adults Diagnosed With Scleroderma Cognitive Exercise Therapy Approach, Control group - Scleroderma, Scleroderma, Localized | Not applicable | Recruiting | Hacettepe University | 48 | 2025-12-04 | 2025-12-18 |
| Patients Diagnosed With Scleroderma and Their Chewing and Swallowing Performance Questionnaire application for child and adult scleroderma patients - Systemic Sclerosis (SSc), Scleroderma | Recruiting | Hacettepe University | 50 | 2025-08-04 | 2025-09-19 | |
| Patients Diagnosed With Scleroderma: Physical Performance and Functionality Questionnaire and functionality application for child and adult scleroderma patients - Systemic Sclerosis (SSc), Scleroderma | Recruiting | Hacettepe University | 50 | 2025-08-04 | 2025-09-19 | |
| Photobiomodulation in Children With Localized Scleroderma Study Group A, Study GrouB, Study Group C - Localized Scleroderma | Not applicable | Completed | New Ismailia National University | 21 | 2025-04-10 | 2026-04-17 |
| Study on the Efficacy of Autologous Fat Grafting in Improving Hair Transplantation Outcomes for Patients With Localized Scleroderma-Related Alopecia Fat grafting combine with hair transplantation, Hair transplantation - Fat Grafting, Hair Transplantation | Not applicable | Completed | Nanfang Hospital, Southern Medical University | 40 | 2024-12-05 | 2026-09-24 |
| Study on the Treatment With Water-filtered Infrared-A (wIRA) Radiation in Patients With Morphea and Sclerotic Graft-versus-host Disease infrared-A (wIRA) - Morphea (Circumscribed Scleroderma), Sclerotic Graft-versus-host Disease (GVHD) | Not applicable | Terminated | Medical University of Graz | 11 | 2021-07-01 | 2025-01-30 |
| Patient Reported Outcomes With UVA-1 Therapy for Treatment of Sclerosing Skin Diseases UVA-1 Phototherapy - Scleroderma, Systemic, Morphea | Not applicable | Active not recruiting | University of Utah | 30 | 2021-06-07 | 2026-10-30 |
| The Influence of Extracorporeal Photopheresis on Skin Sclerosis Scleroderma, Systemic, Graft Vs Host Disease | Completed | Charite University, Berlin, Germany | 6 | 2021-02-12 | 2022-11-17 | |
| Clinical Trial to Evaluate Efficacy and Safety of Dupilumab in Localized Scleroderma Dupilumab 300Mg Solution for Injection, Placebo - Localized Scleroderma | Phase 2 | Completed | University of Cologne | 45 | 2020-05-19 | 2024-10-26 |
| Hyaluronidase in Treating Oral Microstomia in Patients With Sclerosing Skin Disease hyaluronidase injected intradermally - Microstomia, Scleroderma | Early Phase 1 | Withdrawn | Brigham and Women's Hospital | 2020-01-01 | 2021-01-14 | |
| A Study of FCX-013 Plus Veledimex for the Treatment of Moderate to Severe Localized Scleroderma (Morphea) FCX-013, veledimex - Morphea, Scleroderma, Localized | Phase 1 / Phase 2 | Terminated | Castle Creek Biosciences, LLC. | 1 | 2019-12-18 | 2024-01-23 |
| Adult-onset Generalized Morphea Generalized Morphea | Unknown | University Hospital, Strasbourg, France | 100 | 2019-12-01 | 2020-02-13 | |
| Study to Assess Sarilumab in Halting Progression of Morphea Sarilumab - Morphea, Plaque Form | Phase 1 / Phase 2 | Withdrawn | Massachusetts General Hospital | 2019-09-01 | 2021-09-08 | |
| Pain Outcomes Following Intralesional Corticosteroid Injections Corticosteroid with lidocaine, Corticosteroid with normal saline - Keloid, Alopecia Areata | Phase 4 | Completed | Vanderbilt University Medical Center | 31 | 2018-10-01 | 2021-03-11 |
| Pilot Study Evaluating the Efficacy of a Topical PDE4 Inhibitor for Morphea Crisaborole - Morphea | Phase 2 | Completed | Duke University | 8 | 2018-09-01 | 2021-04-01 |
| Molecular Effects of Topical Calcipotriene on Morphea topical calcipotriene 0.005% ointment - Morphea, Localized Scleroderma | Early Phase 1 | Terminated | Northwestern University | 2 | 2015-03-01 | 2018-09-13 |
| Genetic Variants in Linear Localized Scleroderma skin biopsy - Morphea | Not applicable | Completed | University Children's Hospital, Zurich | 50 | 2014-08-01 | 2020-11-10 |
| Fractional Carbon Dioxide Laser Versus UVA 1 in Treatment of Localized Scleroderma Fractional carbon dioxide laser, Ultraviolet A1 phototherapy (UVA1) - Localized Scleroderma | Not applicable | Unknown | Cairo University | 20 | 2013-04-01 | 2014-09-11 |
| Microvascular and Fibrosis Imaging Study Acoustic Radiation Force Impulse (ARFI), Laser Doppler Flowmetry (LDF), Laser Doppler Perfusion Imaging (LDI) - Autoimmune Diseases, Sickle Cell Disease | Completed | Duke University | 63 | 2013-02-01 | 2020-09-11 | |
| Treatment Study Comparing UVA-1 Phototherapy Versus Placebo Treatment for Morphea UVA-1 Phototherapy, Placebo - Scleroderma, Localized, Morphea | Not applicable | Completed | University of Texas Southwestern Medical Center | 14 | 2012-05-01 | 2019-09-25 |
Showing 20 of 31. Sign in to see all of them.
Scleroderma, Diffuse (11) · Scleroderma, Systemic (9) · Keloid (4) · Graft vs Host Disease (3) · Granuloma Annulare (3) · Juvenile-onset scleroderma (3) · Acne Keloid (2) · Autoimmune Diseases (2) · Cicatrix (2) · Dermatomyositis (2) · Eosinophilic Fasciitis (2) · Vasculitis (2) · Acne Vulgaris (1) · Alopecia (1)
Skin Diseases (31) · Skin and Connective Tissue Diseases (31) · Connective Tissue Diseases (30) · Immune System Diseases (5) · Pathological Conditions, Signs and Symptoms (5) · Scleroderma, Systemic (5) · Collagen Diseases (4) · Fibrosis (4) · Hair Diseases (4) · Pathologic Processes (4) · Acneiform Eruptions (3) · Cardiovascular Diseases (3) · Granuloma (3) · Muscular Diseases (3) · Musculoskeletal Diseases (3)
Imiquimod (2) · Adrenal Cortex Hormones (1) · Control Groups (1) · Drug Delivery Systems (1) · Imatinib Mesylate (1) · Injections (1) · Laser-Doppler Flowmetry (1) · Lidocaine (1) · Ointments (1) · Rituximab (1) · Saline Solution (1) · Solutions (1) · Surveys and Questionnaires (1) · Tomography, Optical Coherence (1) · calcipotriene (1)
Duke University (3) · Hacettepe University (3) · University of Michigan (3) · University of Texas Southwestern Medical Center (3) · Brigham and Women's Hospital (1) · Cairo University (1) · Castle Creek Biosciences, LLC. (1) · Charite University, Berlin, Germany (1) · Massachusetts General Hospital (1) · Medical University of Graz (1) · Nanfang Hospital, Southern Medical University (1) · National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) (1) · New Ismailia National University (1) · Northwestern University (1) · The Hospital for Sick Children (1)
United States (15) · Turkey (Türkiye) (3) · Canada (2) · Egypt (2) · France (2) · Germany (2) · Austria (1) · Belgium (1) · China (1) · Switzerland (1)
Adela Cardones, MD (2) · Brian Drolet, MD (1) · Carol Wallace, MD (1) · Christopher B. Hansen, M.D. (1) · Christy Sandborg, MD (1) · Elena Pope, MD (1) · Filip De Keyser, MD, PhD (1) · Heidi Jacobe, M.D. (1) · Heidi Jacobe, MD (1) · Heidi Jacobe, MD, MSCS (1)
PMID 22733975, PMID 22859354, PMID 23039171, PMID 23070991, PMID 23139240, PMID 23588937, PMID 28399931, PMID 33760691
2019 (1)